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Todd Nystul, PhD

Our laboratory primarily uses the Drosophila ovary as a model for studying the fundamental properties of epithelial stem cells, their associated niche, and the connection between epithelial stem cells and cancer. We are interested in questions such as: How is stem cell fate maintained within a dynamic epithelial tissue? What is the nature of the epithelial stem cell niche? What is the role of epithelial stem cells in reproductive physiology? How is a healthy population of stem cells maintained throughout adult life? What can studies of epithelial stem cells teach us about the earliest steps in cancer formation?

Selected Publications

Sahai-Hernandez, P. & Nystul, T. G. A dynamic population of stromal cells contributes to the follicle stem cell niche in the Drosophila ovary. Development (Cambridge, England) 140, 4490–4498 (2013).

Hafezi Y, and Nystul TG “Advanced Techniques for Cell Lineage Labelling in Drosophila.” eLS. 2012.

Sahai-Hernandez P, Castanieto A, and Nystul TG, “Drosophila models of epithelial stem cells and their niches.” WIREs Dev Biol. 2012.

Nystul TG, Spradling AC, “Regulation of epithelial stem cell replacement and follicle formation in the Drosophila ovary,” Genetics, 2010 February; 184(2):503-15.

Fox, DT, Morris, LX, Nystul, TG, and Spradling, AC, “Lineage analysis of stem cells” StemBook, 2009 January,

Spradling AC, Nystul T, Lighthouse D, Morris L, Fox D, Cox R, Tootle T, Frederick R, Skora A., “Stem Cells and Their Niches: Integrated Units That Maintain Drosophila Tissues.”  Cold Spring Harb Symp Quant Biol. 2008 November.

Nystul TG, Spradling AC, “An Epithelial Niche in the Drosophila Ovary Undergoes Long-Range Stem Cell Replacement.” Cell Stem Cell, 2007 September; 1(3):277-285.

Nystul TG, Spradling AC, “Breaking out of the mold: diversity within adult stem cells and their niches.”  Current Opinion in Genetics and Development, 2006 October; 16(5):463-8.

Buszczak M, Paterno S, Lighthouse D, Bachman J, Planck J, Owen S, Skora AD, Nystul TG, Ohlstein B, Allen A, Wilhelm JE, Murphy TD, Levis RW, Matunis E, Srivali N, Hoskins RA, Spradling AC. “The carnegie protein trap library: a versatile tool for Drosophila developmental studies.” Genetics, 2007 March; 175(3):1505-31.

Nystul TG, Roth MB, “Carbon monoxide-induced suspended animation protects against hypoxic damage in Caenorhabditis elegans.” Proc Natl Acad Sci U S A, 2004 June 15; 101(24):9133-6

Nystul TG*, Goldmark JG*, Padilla PA*, Roth MB, "Suspended animation in C. elegans requires the spindle checkpoint." Science, 2003 November 7; 302(5647):1038-41. *Co-primary authors.

Padilla PA, Nystul TG, Zager RA, Johnson AC, Roth MB, "Dephosphorylation of cell cycle-regulated proteins correlates with anoxia-induced suspended animation in Caenorhabditis elegans." Mol Biol Cell. 2002 May; 13(5):1473-83.