
Professor in Residence
Department of Dermatology
Primary Thematic Area
Secondary Thematic Area
Research Summary
Defining the cellular and molecular mechanisms of immune regulation in peripheral tissues
The central focus of my lab is to understand how immune responses are regulated in tissues and how this knowledge can be exploited for therapeutic benefit. To this end, we currently have two areas of active investigation:
- Understanding how regulatory T cells (Tregs) control immune responses in tissues
- Understanding the ‘alternative’ functions of Tregs in tissues
Approach
Because of its complex immunological properties, its accessibility, and potential for clinical translation, the skin is the model peripheral tissue that we currently study. Approximately 50% of our research employs a reductionist approach, utilizing transgenic animal models to ask fundamental questions of how the immune system functions in skin at both the cellular and molecular levels. The other half of our work focuses on doing functional immunology with human skin, human blood and humanized mice.
Publications
The Inflammatory Landscape of a Whole-Tissue Explant Model of Hidradenitis Suppurativa.
Experimental dermatology
The emerging fungal pathogen Candida auris induces IFNγ to colonize mammalian hair follicles.
bioRxiv : the preprint server for biology
CD4+ T Cells Occupy Perivascular and Perifollicular Niches in Healthy Human Skin.
Experimental dermatology
A Novel Whole Tissue Explant Model of Hidradenitis Suppurativa.
bioRxiv : the preprint server for biology
Interleukin-2-induced skin inflammation.
European journal of immunology
Tertiary lymphoid structures sustain cutaneous B cell activity in hidradenitis suppurativa.
JCI insight
Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche.
Science immunology
Tertiary Lymphoid Structures Sustain Cutaneous B cell Activity in Hidradenitis Suppurativa.
bioRxiv : the preprint server for biology
Xenograft Skin Model to Manipulate Human Immune Responses In Vivo.
Journal of visualized experiments : JoVE
Transforming growth factor-ß1 in regulatory T cell biology.
Science immunology
MTHFD2, metabolic mastermind of CD4+ T cell destiny.
Science immunology
Identifying and antagonizing the interactions between layilin and glycosylated collagens.
Cell chemical biology
Author Correction: Transcriptional landscape of epithelial and immune cell populations revealed through FACS-seq of healthy human skin.
Scientific reports
Transcriptomic Profiling of Plaque Psoriasis and Cutaneous T-Cell Subsets during Treatment with Secukinumab.
JID innovations : skin science from molecules to population health
Tregs and inflammation-bring it on!
Science immunology
Layilin Anchors Regulatory T Cells in Skin.
Journal of immunology (Baltimore, Md. : 1950)
Regulatory T cells promote innate inflammation after skin barrier breach via TGF-ß activation.
Science immunology
Regulatory T Cells and Inflammatory Mediators in Autoimmune Disease.
The Journal of investigative dermatology
T-Cell Adhesion in Healthy and Inflamed Skin.
JID innovations
Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment.
The Journal of experimental medicine
TregGF-ß: Deletion of TGF-ß in Tregs revisited.
Science immunology
Histologic Progression of Acne inversa/hidradenitis suppurativa: Implications for future Investigations and therapeutic intervention.
Experimental dermatology
Single cell RNA-seq of psoriatic skin identifies pathogenic Tc17 subsets and reveals distinctions between CD8+ T cells in autoimmunity and cancer.
The Journal of allergy and clinical immunology
Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature.
Cell reports. Medicine
Cutting Edge: Tissue Antigen Expression Levels Fine-Tune T Cell Differentiation Decisions In Vivo.
Journal of immunology (Baltimore, Md. : 1950)
Layilin augments integrin activation to promote antitumor immunity.
The Journal of experimental medicine
Keepin' it regulatory: Foxp3 gets a BAFfling SWItch.
Science immunology
Exhausted T cell signature predicts immunotherapy response in ER-positive breast cancer.
Nature communications
A novel humanized mouse model to study the function of human cutaneous memory T cells in vivo in human skin.
Scientific reports
Tumor Immune Profiling-Based Neoadjuvant Immunotherapy for Locally Advanced Melanoma.
Annals of surgical oncology
Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair.
Science immunology
Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair.
Cell stem cell
Sex drives Tregs into fat.
Science immunology
Regulatory T cells in skin are uniquely poised to suppress profibrotic immune responses.
Science immunology
Regulatory T cells in inflammatory skin disease: from mice to humans.
International immunology
Human CD4+CD103+ cutaneous resident memory T cells are found in the circulation of healthy individuals.
Science immunology
CD27 Promotes CD4+ Effector T Cell Survival in Response to Tissue Self-Antigen.
Journal of immunology (Baltimore, Md. : 1950)
Y'all comeback now.
Science immunology
a-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by a-TGFß antibody to promote durable rejection and immunity in squamous cell carcinomas.
Journal for immunotherapy of cancer
Adoptive Regulatory T Cell Therapy in a Patient with Systemic Lupus Erythematosus.
Arthritis & rheumatology (Hoboken, N.J.)
Inflammatory T cells maintain a healing disposition.
Science immunology
The TNFRSF members CD27 and OX40 coordinately limit TH17 differentiation in regulatory T cells.
Science immunology
Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch.
Proceedings of the National Academy of Sciences of the United States of America
Colitis interruptus: LAGing gut inflammation.
Science immunology
Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization.
Microbiome
RNA-seq and flow-cytometry of conventional, scalp, and palmoplantar psoriasis reveal shared and distinct molecular pathways.
Scientific reports
A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments.
Nature medicine
Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation.
The Journal of clinical investigation
Say it isn't pso: IL-25 drives skin inflammation.
Science immunology
Skin-Resident T Cells Drive Dermal Dendritic Cell Migration in Response to Tissue Self-Antigen.
Journal of immunology (Baltimore, Md. : 1950)
SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation.
The journal of allergy and clinical immunology. In practice
Injectable Polymeric Cytokine-Binding Nanowires Are Effective Tissue-Specific Immunomodulators.
ACS nano
Chronic Helicobacter cinaedi cellulitis diagnosed by microbial polymerase chain reaction.
JAAD case reports
Regulatory T cells in skin.
Immunology
Partially exhausted tumor-infiltrating lymphocytes predict response to combination immunotherapy.
JCI insight
Skin-infiltrating, interleukin-22-producing T cells differentiate pediatric psoriasis from adult psoriasis.
Journal of the American Academy of Dermatology
Transcriptional landscape of epithelial and immune cell populations revealed through FACS-seq of healthy human skin.
Scientific reports
Liver Metastasis and Treatment Outcome with Anti-PD-1 Monoclonal Antibody in Patients with Melanoma and NSCLC.
Cancer immunology research
Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.
Cell host & microbe
Warfarin-Associated Nonuremic Calciphylaxis.
JAMA dermatology
Response to Interleukin (IL)-17 Inhibition in an Adolescent With Severe Manifestations of IL-36 Receptor Antagonist Deficiency (DITRA).
JAMA dermatology
Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma.
The Journal of clinical investigation
Plasmacytoid dendritic cells (pDCs) and regulatory T (Treg) cells may be the key to viral reactivation in drug-induced hypersensitivity syndrome (DIHS).
Journal of the American Academy of Dermatology
Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing.
Journal of immunology (Baltimore, Md. : 1950)
The distribution of cutaneous metastases correlates with local immunologic milieu.
Journal of the American Academy of Dermatology
Regulatory T cell memory.
Nature reviews. Immunology
Mechanisms of human autoimmunity.
The Journal of clinical investigation
COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis.
Nature genetics
Melanoma immunotherapy.
Cancer biology & therapy
A case of Wong-type dermatomyositis with concomitant anti-MDA5 features.
Journal of the American Academy of Dermatology
Plaque-based sub-blistering dosimetry: Reaching PASI-75 after two treatments with 308-nm excimer laser in a generalized psoriasis patient.
The Journal of dermatological treatment
Memory regulatory T cells reside in human skin.
The Journal of clinical investigation
Cutting edge: Self-antigen controls the balance between effector and regulatory T cells in peripheral tissues.
Journal of immunology (Baltimore, Md. : 1950)
An open-label study of anakinra for the treatment of moderate to severe hidradenitis suppurativa.
Journal of the American Academy of Dermatology
Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Depleting tumor-specific Tregs at a single site eradicates disseminated tumors.
The Journal of clinical investigation
Cutting Edge: memory regulatory t cells require IL-7 and not IL-2 for their maintenance in peripheral tissues.
Journal of immunology (Baltimore, Md. : 1950)
The life of regulatory T cells.
Annals of the New York Academy of Sciences
In vivo cardiac phase response curve elucidates human respiratory heart rate variability.
Nature communications
Treating human autoimmunity: current practice and future prospects.
Science translational medicine
Erosive pustular dermatosis of the scalp: a review with a focus on dapsone therapy.
Journal of the American Academy of Dermatology
Phase II study of intraperitoneal recombinant interleukin-12 (rhIL-12) in patients with peritoneal carcinomatosis (residual disease < 1 cm) associated with ovarian cancer or primary peritoneal carcinoma.
Journal of translational medicine
Diaphragm and lubricant gel for prevention of HIV acquisition in southern African women: a randomised controlled trial.
Lancet (London, England)
CD200, a "no danger" signal for hair follicles.
Journal of dermatological science
Characterization of CD 200-receptor expression in the murine epidermis.
The Journal of investigative dermatology
Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance?
The Journal of investigative dermatology
Concurrent presence of both patient and donor t(14;18) in a follicular lymphoma patient after undergoing allogeneic BMT: implications for minimal residual disease detection post-transplant.
Bone marrow transplantation
Subcutaneous plasmacytomas with tropism to sites of previous trauma in a multiple myeloma patient treated with an autologous bone marrow transplant.
American journal of hematology
Phase I study of intraperitoneal recombinant human interleukin 12 in patients with Müllerian carcinoma, gastrointestinal primary malignancies, and mesothelioma.
Clinical cancer research : an official journal of the American Association for Cancer Research
'Rings' of F-actin form around the nucleus in cultured human MCF7 adenocarcinoma cells upon exposure to both taxol and taxotere.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
Regimen-related toxicity of myeloablative chemotherapy with BCNU, thiotepa, and etoposide followed by autologous stem cell rescue for children with newly diagnosed glioblastoma multiforme: report from the Children's Cancer Group.
Medical and pediatric oncology
Myeloablative chemotherapy with autologous bone marrow rescue in young children with recurrent malignant brain tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
High-dose carboplatin, thiotepa, and etoposide with autologous stem-cell rescue for patients with recurrent medulloblastoma. Children's Cancer Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Enolate Additions to a Chiral 3-Hydroxypropionate 2,3-Dication Equivalent. Enantioselective Synthesis of beta,delta-Dihydroxy Esters.
The Journal of organic chemistry
Primary amyloidoma of the brain: CT and MR presentation.
AJNR. American journal of neuroradiology
Development of a non-selecting, non-perturbing method to study human brain tumor cell invasion in murine brain.
Journal of neuro-oncology
Microtubule aggregates in a clival chordoma.
Archives of pathology & laboratory medicine
Neoplastic meningitis as the presentation of occult primitive neuroectodermal tumors.
Journal of child neurology
Phase I trial of a 90-minute infusion of the fusion toxin DAB486IL-2 in hematological cancers.
Cancer research
Developmental regulation of annexin II (Lipocortin 2) in human brain and expression in high grade glioma.
Cancer research
Low dose rate radiotherapy for transplantable gliosarcoma in the rat brain.
Journal of neuro-oncology
AIDS-related vacuolar myelopathy is not associated with coinfection by human T-lymphotropic virus type I.
Annals of neurology
Dissociation of AIDS-related vacuolar myelopathy and productive HIV-1 infection of the spinal cord.
Neurology
Clinical and laboratory changes induced by alpha interferon in chronic lymphocytic leukemia--a pilot study.
American journal of hematology
Initial clinical studies with copovithane.
Journal of biological response modifiers
Depression of murine natural killer cell cytotoxicity by isobutyl nitrite.
Cancer immunology, immunotherapy : CII