Lily Jan, PhD

Howard Hughes Medical Institute investigator
Professor
Department of Physiology
Department of Biochemistry and Biophysics
+1 415 476-8748

Potassium channels regulate neuronal signaling, control the flow of salt across epithelia, heart rate, vascular tone, and the release of hormones such as insulin, and protect neurons and muscles under metabolic stress. In order to study potassium channels, we have chosen to isolate individual potassium channel genes so that the channels they give rise to can be studied one at a time, and then compared with potassium channels in native tissues. We have recently extended our studies to the cloning and characterization of calcium-activated chloride channels with wide distribution and diverse physiological functions.

Thus our channel studies were initiated by positional cloning of the Shaker voltage-gated potassium (Kv) channel gene in the fruit fly and expression cloning of inwardly rectifying potassium (Kir) channels - founding members of two large, distantly related families of potassium channels - as well as expression cloning of calcium-activated chloride channel (CaCC) of a novel ion channel family. Mutations of potassium channels in the Kv and Kir families cause diseases of the brain (epilepsy, episodic ataxia), ear (deafness), kidney (hypertension), pancreas (hyperinsulinemic hypoglycemia of infancy), heart (arrhythmia), skeletal muscle (periodic paralysis), as well as developmental abnormalities of neural crest-derived tissues (Andersen's syndrome). Understandably, potassium channel openers and blockers have been developed for pharmaceutical purposes. Likewise, CaCC blockers may reduce hypertension whereas CaCC enhancement has been considered as potential treatment for cystic fibrosis and other pulmonary diseases including asthma.  A better understanding of the function of these channels will therefore not only satisfy our curiosity, it will have clinical significance. We are currently taking a range of experimental approaches - electrophysiological, cell biological, biochemical and genetic - to examine the physiological functions of potassium channels and calcium-activated chloride channels.

Primary Thematic Area: 
Neurobiology
Secondary Thematic Area: 
Vascular & Cardiac Biology
Research Summary: 
Potassium Channels

Websites

Publications: 

Inferior Olivary TMEM16B Mediates Cerebellar Motor Learning.

Neuron

Zhang Y, Zhang Z, Xiao S, Tien J, Le S, Le T, Jan LY, Yang H

Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity.

Cell reports

Orr BO, Gorczyca D, Younger MA, Jan LY, Jan YN, Davis GW

Electron cryo-microscopy structure of the mechanotransduction channel NOMPC.

Nature

Jin P, Bulkley D, Guo Y, Zhang W, Guo Z, Huynh W, Wu S, Meltzer S, Cheng T, Jan LY, Jan YN, Cheng Y

Age-dependent diastolic heart failure in an in vivo Drosophila model.

eLife

Klassen MP, Peters CJ, Zhou S, Williams HH, Jan LY, Jan YN

TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation.

Neuron

Yadav S, Oses-Prieto JA, Peters CJ, Zhou J, Pleasure SJ, Burlingame AL, Jan LY, Jan YN