Immune responses are regulated by membrane receptors that serve to activate or inhibit cell proliferation and clonal expansion, cytokines production, and cell-mediated cytotoxicity. Our lab focuses on the human and mouse activating and inhibitory receptors that are predominantly expressed by Natural Killer (NK) cells, but are also present on subsets of effector/memory T cells and some myeloid cells. We are investigating how NK cells recognize and eliminate virus-infected cells and tumors. Recent studies from our lab have demonstrated that NK cells, like T cells and B cells, possess immunological memory after infection with cytomegatovirus. Studies are directed towards defining the molecular basis for NK cell memory.
Sun, J.C., J.N. Beilke, and L.L. Lanier. 2009. Adaptive immune features of Natural Killer cells. Nature 457:557-561.
Champsaur, M.A. and L.L. Lanier, 2010. Effect of NKG2D ligand expression on host immune responses. Immunological Reviews 235:267-285.
Orr, M.T., W.J. Murphy, and L.L. Lanier. 2010. Unlicensed NK cells dominate the response to cytomegalovirus infection. Nature Immunology 11:321-327.
Orr, M.T. and L.L. Lanier. 2010. Natural Killer cell education and tolerance. 2010. Cell 142:847-856.
Sun, J.C. and L.L. Lanier. 2011. NK cell development, homeostasis, and function - parallels with CD8+ T cells. Nature Reviews Immunology 11:645-657.
Lopez-Verges, S., J.M. Milush, B.S. Schwartz, M.J. Pando, J. Jarjoura, V.A. York, J.P. Houchins, S. Miller, S-M. Kang, P.J. Norris, D.F. Nixon, and L. L. Lanier. 2011. Expansion of a unique CD57+NKG2Chi Natural Killer cell subset during acute human cytomegalovirus infection. Proc. Natl. Acad. Sci 108:14725-14732.
Bezman, N.A., T. Chakraborty, T. Bender, and L.L. Lanier. 2011. Mir-150 regulates development of NK and iNKT cells. J. Exp. Med.208:2717-2731.
Sun, J.C., S. Madera, N.A. Bezman, J.N. Beilke, M.H. Kaplan, and L.L. Lanier. 2012. Pro-inflammatory cytokine signaling required for the generation of NK cell memory. J. Exp. Med. 209:947-954.
Nabekura, T., M. Kanaya, A. Shibuya, G. Fu, N.R.J. Gascoigne, and L.L. Lanier. 2014. Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection. Immunity 40:225-234 PMID: 24440149 PMC3943894
Hendricks, D.W., H.H. Balfour, Jr., S.K. Dunmire, D.O. Schmeling, K.A. Hogquist, and L.L. Lanier. 2014. Cutting Edge: NKG2ChiCD57+ Natural Killer cells respond specifically to acute infection with cytomegalovirus and not Epstein-Barr virus. J. Immunol. 192:4492-4496. PMID: 24740502 PMC4013527