Jeffrey Bush, PhD

Assistant Professor
Department of Cell & Tissue Biology
+1 415 476-9459

Our lab studies basic mechanisms by which signaling between cells coordinates morphogenesis. Understanding this control has significance beyond its fundamental importance in development since birth defects are the leading cause of death for infants during the first year of life. Craniofacial anomalies are the most common class of congenital defect in humans, with three quarters of all malformations identified at birth involving craniofacial dysmorphogenesis.  We utilize multiple approaches based in mouse genetics to understand fundamental signaling processes as they relate to craniofacial development and disease. In addition to mouse genetics approaches, we utilize human induced pluripotent stem cells and live imaging to understand the cellular and molecular control of morphogenesis.

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
Human Genetics
Research Summary: 
Signaling control of craniofacial development and congenital disease



Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation.

The Journal of cell biology

O'Neill AK, Kindberg AA, Niethamer TK, Larson AR, Ho HH, Greenberg ME, Bush JO

Convergence and extrusion are required for normal fusion of the mammalian secondary palate.

PLoS biology

Kim S, Lewis AE, Singh V, Ma X, Adelstein R, Bush JO

Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate.

Developmental dynamics : an official publication of the American Association of Anatomists

Agrawal P, Wang M, Kim S, Lewis AE, Bush JO