Jeffrey Bush, PhD

Assistant Professor
Department of Cell & Tissue Biology
+1 415 476-9459

Our lab studies basic mechanisms by which signaling between cells coordinates morphogenesis. Understanding this control has significance beyond its fundamental importance in development since birth defects are the leading cause of death for infants during the first year of life. Craniofacial anomalies are the most common class of congenital defect in humans, with three quarters of all malformations identified at birth involving craniofacial dysmorphogenesis.  We utilize multiple approaches based in mouse genetics to understand fundamental signaling processes as they relate to craniofacial development and disease. In addition to mouse genetics approaches, we utilize human induced pluripotent stem cells and live imaging to understand the cellular and molecular control of morphogenesis.

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
Human Genetics
Research Summary: 
Signaling control of craniofacial development and congenital disease

Websites

Publications: 

Live Imaging of Mouse Secondary Palate Fusion.

Journal of visualized experiments : JoVE

Kim S, Prochazka J, Bush JO

EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells.

Stem cell reports

Niethamer TK, Larson AR, O'Neill AK, Bershteyn M, Hsiao EC, Klein OD, Pomerantz JH, Bush JO

Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation.

The Journal of cell biology

O'Neill AK, Kindberg AA, Niethamer TK, Larson AR, Ho HH, Greenberg ME, Bush JO