Eric Verdin, MD

Senior Investigator, Gladstone Institute of Cardiovascular Disease
Associate Professor
Department of Medicine
+1 415 734-4808
Our laboratory focuses on the biology of HIV with a particular emphasis on its transcriptional regulation and the role of chromatin. We are currently focusing on understanding the mechanism of HIV latency, which is mediated by the transcriptional inactivation of the HIV promoter. We also study how HIV proteins modify differentiated functions of immune cells during the infection process.

A second focus of the lab is the role of HDAC7, a histone deacetylase, in lymphocyte development. HDAC7 is highly expressed in double positive (CD4 and CD8) developing T cells.  We found that HDAC7 regulates the expression of a cassette of genes that play a critical role in the process of positive and negative selection. We are currently studying a thymus-specific HDAC7 knockout mouse.

A third focus of the lab is the role of acetylation in mitochondrial functions. We study a protein deacetylase, called SIRT3, and its role in metabolic control and aging.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
Immunology
Research Summary: 
HIV Pathogenesis and lymphocyte biology

Websites

Publications: 

The mTOR Complex Controls HIV Latency.

Cell host & microbe

Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E

SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage.

American journal of physiology. Lung cellular and molecular physiology

Bindu S, Pillai VB, Kanwal A, Samant S, Mutlu G, Verdin E, Dulin NO, Gupta MP

Aging Promotes Sirtuin 3-Dependent Cartilage Superoxide Dismutase 2 Acetylation and Osteoarthritis.

Arthritis & rheumatology (Hoboken, N.J.)

Fu Y, Kinter M, Hudson J, Humphries KM, Lane RS, White JR, Hakim M, Pan Y, Verdin E, Griffin TM

Characterization of a new cucurbit-infecting ipomovirus from Sudan.

Archives of virology

Desbiez C, Verdin E, Tepfer M, Wipf-Scheibel C, Millot P, Dafalla G, Lecoq H

Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity.

eLife

Shirakawa K, Wang L, Man N, Maksimoska J, Sorum AW, Lim HW, Lee IS, Shimazu T, Newman JC, Schröder S, Ott M, Marmorstein R, Meier J, Nimer S, Verdin E