Eric Verdin, MD
A second focus of the lab is the role of HDAC7, a histone deacetylase, in lymphocyte development. HDAC7 is highly expressed in double positive (CD4 and CD8) developing T cells. We found that HDAC7 regulates the expression of a cassette of genes that play a critical role in the process of positive and negative selection. We are currently studying a thymus-specific HDAC7 knockout mouse.
A third focus of the lab is the role of acetylation in mitochondrial functions. We study a protein deacetylase, called SIRT3, and its role in metabolic control and aging.