Bruce Wang, MD

Assistant Prof In Residence
Department of Medicine - Gastroenterology
+1 415 476-6160

My lab studies how the different cell types in the liver, in particular the hepatocyte, are generated during development, patterned and maintained during adulthood, and regenerate after injury. Our long-term goals are to improve the understanding of liver disease pathophysiology and develop novel methods of treatment for liver diseases, including cell replacement therapy. Currently, we have two major research focuses: 1) understanding the biology of adult hepatocyte stem cells and 2) developing a liver cell atlas. We take innovative and integrated approaches to address these two areas using the tools of stem cell biology, developmental biology, genomics and tissue engineering.

I also study the porphyrias, a group of inherited diseases related to defects in heme synthesis pathway. I am a member of the Porphyrias Consortium, a NIH sponsored Rare Disease Clinical Research Consortium. The purpose of the network is to integrate translational studies of the porphyrias with clinical trials testing new therapeutics.

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
We study how the different cell types in the liver, in particular the hepatocyte, are generated during development, patterned and maintained during adulthood, and regenerate after injury.

Websites

Publications: 

Pitfalls in Erythrocyte Protoporphyrin Measurement for Diagnosis and Monitoring of Protoporphyrias.

Clinical chemistry

Gou EW, Balwani M, Bissell DM, Bloomer JR, Bonkovsky HL, Desnick RJ, Naik H, Phillips JD, Singal AK, Wang B, Keel S, Anderson KE

Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver.

Nature

Wang B, Zhao L, Fish M, Logan CY, Nusse R

Acute Hepatic Porphyria.

Journal of clinical and translational hepatology

Bissell DM, Wang B

Acute liver failure with thyrotoxicosis treated with liver transplantation.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

Cascino MD, McNabb B, Gardner DG, Woeber KA, Fox AN, Wang B, Fix OK

Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration.

The Journal of clinical investigation

Malato Y, Naqvi S, Schürmann N, Ng R, Wang B, Zape J, Kay MA, Grimm D, Willenbring H