Biao Wang, PhD

Asst Professor in Residence
Cardiovascular Research Institute
+1 415 502-2023

Adipose tissue regulates systemic energy homeostasis by storing lipids as triglycerides and by secreting adipokines. Dysfunctions of adipose tissue in either obesity (too much fat) or lipoatrophy (too little fat) patients cause metabolic syndromes such as insulin resistance and dyslipidemia. Using orthologous genetic systems (Drosophila and mouse), we are interested in 1) identifying genetic hierarchy of adipocyte lineage development, and 2) investigating molecular mechanisms of adipose tissue remodeling in health and disease states.

Primary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Regulatory mechanisms of adipose tissue development and function

Websites

Publications: 

A hormone-dependent module regulating energy balance.

Cell

Wang B, Moya N, Niessen S, Hoover H, Mihaylova MM, Shaw RJ, Yates JR, Fischer WH, Thomas JB, Montminy M

The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila.

Cell metabolism

Wang B, Goode J, Best J, Meltzer J, Schilman PE, Chen J, Garza D, Thomas JB, Montminy M

Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity.

Cancer cell

Wang B, Xiao Y, Ding BB, Zhang N, Yuan Xb, Gui L, Qian KX, Duan S, Chen Z, Rao Y, Geng JG