 
Professor
      
      Department of Psychiatry
          Primary Thematic Area
              
          Secondary Thematic Area
              
          Research Summary
              Brain-immune interactions throughout the lifespan
          Mentorship Development
              9/2020  Mentoring Across Differences
5/2021  Sharpening your Mentoring Skills (SyMS) 
Our group aims to understand the complex interactions between multiple cell types within the brain, including neurons, astrocytes, and microglia, and in particular, to define how innate immune signals shape healthy brain development, plasticty, and aging, both within the brain and in communication with peripheral immunity. Our goal is to achieve a cellular and molecular understanding of brain-immune communication that can inform new immune-based therapies for psychiatric, neurodevelopmental, and neurodegenerative illnesses.
Websites
          
      Publications
Publisher Correction: Circuit and molecular architecture of a ventral hippocampal network.
Nature neuroscience
      
            
      
      In situ and transcriptomic identification of microglia in synapse-rich regions of the developing zebrafish brain.
Nature communications
      
            
      
      Reactive astrocyte nomenclature, definitions, and future directions.
Nature neuroscience
      
            
      
      Circuit and molecular architecture of a ventral hippocampal network.
Nature neuroscience
      
            
      
      Location, Location, Location: Transcriptional Control of Astrocyte Heterogeneity.
Trends in immunology
      
            
      
      Astrocytes and Microglia: In Sickness and in Health.
Trends in neurosciences
      
            
      
      The immune system and psychiatric disease: a basic science perspective.
Clinical and experimental immunology
      
            
      
      Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes.
Nature neuroscience
      
            
      
      Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development.
Science (New York, N.Y.)
      
            
      
      Dynamism of an Astrocyte In Vivo: Perspectives on Identity and Function.
Annual review of physiology
      
            
      
      Regional astrocyte allocation regulates CNS synaptogenesis and repair.
Science (New York, N.Y.)
      
            
      
      Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord.
Development (Cambridge, England)
      
            
      
      Astrocytes and disease: a neurodevelopmental perspective.
Genes & development
      
            
      
      Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo.
Developmental biology
      
            
      
      Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing.
Nature
      
            
      
      Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways.
Genes & development
      
            
      
      Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors.
Cold Spring Harbor symposia on quantitative biology
      
            
      
      Diverse mechanisms regulate stem cell self-renewal.
Current opinion in cell biology
      
            
      
      