Understanding the basic biology and realizing applicable strategies to enable liver tissue engineering for the treatment of end-stage liver disease.
Mentorship Development:
12/19/19 ACRA: Setting Training Expectations for Trainees on the Academic Career Track (1.5 hours)
2/16/21 Three Truths & Three Tries: Facing & Overcoming Critical Social Justice Challenges at the Micro, Mezzo & Macro Levels
We aim to elucidate previously unrecognized paracrine and endocrine signaling pathways that regulate stem cell fate and differentiation decisions that modulate body composition and metabolism.
We seek to understand how the organization of the nucleus is established, specialized across cell types, and maintained over time to influence cellular identity.
Mentorship Development:
11/21/19 Equity and Inclusion in the Lab (2 hours)
11/10/20 Optimizing the Efficiency of Your Lab
5/2021 Sharpening your Mentoring Skills (SyMS)
We study how genetic changes that accumulated over the last 6 million years of human evolution influence specialized features of brain development using single cell genomics, cerebral organoid models of ape brain development, and genome engineering.
We study how the different cell types in the liver, in particular the hepatocyte, are generated during development, patterned and maintained during adulthood, and regenerate after injury.
