David Erle, MD

Director, UCSF Functional Genomics Core Facility
Professor
Department of Medicine
+1 415 514-4370

Dr. Erle received an A.B. degree (Biochemistry) from Harvard College in 1980 and an M.D. degree from UCSF in 1984. He was trained in internal medicine and in pulmonary disease at UCSF. As a CVRI research fellow training at the UCSF Lung Biology Center, he studied leukocyte integrins with Robert Pytela and Dean Sheppard. He joined the Lung Biology Center faculty in 1990. His academic activities include laboratory research and clinical teaching. He is the Director of the Functional Genomics Core Facility, UCSF Sandler Center for Basic Research in Asthma. He is a member of the UCSF Program in Immunology and the Cardiovascular Research Institute. He serves as an Attending Physician in the San Francisco General Hospital Medical ICU and the Pulmonary Consultation Service.

Research Interests:

Asthma: role of airway epithelial cells. The airway epithelium is increasingly recognized as a key participant in asthma and other major lung diseases. Our group has developed models to understand how IL-13 and other cytokines produced during airway inflammation act on epithelial cells to produce disease. Ongoing work is investigating how specialized molecules in the endoplasmic reticulum contribute to mucus overproduction in asthma and how micro-RNAs affect airway epithelial cell differentiation and function.

Functional genomics. Powerful genomics tools such as next generation sequencing and microarrays offer new opportunities for understanding lung biology and disease. Members of our group have extensive experience with these technologies. Projects within the lab and collaborative projects with many investigators at UCSF and beyond are using these technologies to investigate pulmonary cell biology, mouse disease models, and samples from humans with asthma and other diseases. We are also pursuing novel genomics approaches, including development of a system for high-throughput analysis of the function of sequences from 3’ untranslated regions of mRNAs.

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Human Genetics
Research Summary: 
Immunopathogenesis of Asthma; Genomics of Disease

Websites

Featured Publications: 

Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma.

The Journal of clinical investigation

Bonser LR, Zlock L, Finkbeiner W, Erle DJ

Massively parallel functional annotation of 3' untranslated regions.

Nature biotechnology

Zhao W, Pollack JL, Blagev DP, Zaitlen N, McManus MT, Erle DJ

Airway epithelial miRNA expression is altered in asthma.

American journal of respiratory and critical care medicine

Solberg OD, Ostrin EJ, Love MI, Peng JC, Bhakta NR, Hou L, Nguyen C, Solon M, Nguyen C, Barczak AJ, Zlock LT, Blagev DP, Finkbeiner WE, Ansel KM, Arron JR, Erle DJ, Woodruff PG

Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.

American journal of respiratory and critical care medicine

Park SW, Verhaeghe C, Nguyenvu LT, Barbeau R, Eisley CJ, Nakagami Y, Huang X, Woodruff PG, Fahy JV, Erle DJ

The protein disulfide isomerase AGR2 is essential for production of intestinal mucus.

Proceedings of the National Academy of Sciences of the United States of America

Park SW, Zhen G, Verhaeghe C, Nakagami Y, Nguyenvu LT, Barczak AJ, Killeen N, Erle DJ

Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma.

Nature medicine

Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ