Arthur Weiss, MD, PhD

Ephraim P. Engleman Distinguished Professor
Professor
Department of Medicine
aweiss@medicine.ucsf.edu

Research Interest:

The response of lymphocytes to antigen which initiates an antigen specific immune response also represents a unique opportunity to study how complex molecular interactions between cells can lead to developmental decisions, cell differentiation and proliferation. We are interested in understanding how receptors involved in antigen recognition can initiate signal transduction events that regulate cell responses in the immune system. We know that receptors involved in antigen recognition functionally interact with tyrosine kinases and phosphatases, enzymes that regulate protein phosphorylation, to induce signaling pathways that regulate cellular responses and gene expression. We are using genetically selective small molecule inhibitors of kinases together with phosphatase mutants to study how thresholds for the initiation of immune responses are set and how feedback circuits influence responses. We would like to understand how the tyrosine kinases and phosphatases in these pathways are regulated and how they control cellular responses in development, in normal immune responses and in autoimmune diseases such as lupus and rheumatoid arthritis.

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
Our lab focuses on the roles of tyrosine kinases and phosphatases in regulating lymphocyte activation, and studies how abnormalities in tyrosine phosphorylation pathways can lead to immunologically-mediated diseases.

Websites

Publications: 

Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells.

Journal of immunology (Baltimore, Md. : 1950)

Ashouri JF, Weiss A

CD28 Costimulation: From Mechanism to Therapy.

Immunity

Esensten JH, Helou YA, Chopra G, Weiss A, Bluestone JA

A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.

The Journal of experimental medicine

Chan AY, Punwani D, Kadlecek TA, Cowan MJ, Olson JL, Mathes EF, Sunderam U, Fu SM, Srinivasan R, Kuriyan J, Brenner SE, Weiss A, Puck JM