Using functional + spatial molecular tools to study post-transcriptional RNA + metabolic networks at single cell resolution and in 3D; Re-engineering/re-wiring cell fates for regenerative therapies
We study the origins of clonal blood disorders with focus on developmental hematopoiesis and forces driving clonal competition in the context of inherited cancer predisposition conditions.
We leverage interdisciplinary approaches in bioengineering, endocrinology, and physiology to determine molecular mechanisms of tissue crosstalk in osteoarthritis.
Our team studies how chromatin receives, processes, and amplifies environmental stress signals that drive changes in cell states leading to heart disease.
Our lab leverages cutting-edge machine learning and experimental genomics to map the gene regulatory networks disrupted in cardiovascular disease and discover network-correcting therapeutics.
The research interest of my lab lies at the intersection of CRISPR-based genome editing and protein/cell engineering with special focus on hematopoietic stem cells and red blood cell disorders.
