We develop and apply biomimetic human tissue models to dissect mechanisms of morphogenesis and mechanobiology as applied to cancer and cardiovascular disease.
Development of gene therapy, oncolytic virotherapy, and immunotherapy for translational application to cancer (particularly CNS tumors), and genetic engineering strategies for regenerative medicine.
We strive to understand the events that drive progression of pre-malignant disease into invasive cancer, focusing on gastric and esophageal adenocarcinoma.
We study tumor evolution, drug sensitization and oncogene network alterations in patients in order to improve precision medicine therapies for hormone-related and genitourinary cancers.