Our group develops and applies advances in synthetic biology to better understand biological systems and then to re-engineer these systems to tackle disease.
We study the origins of clonal blood disorders with focus on developmental hematopoiesis and forces driving clonal competition in the context of inherited cancer predisposition conditions.
We use synthetic biology and high-throughput functional genetic screens to understand antigen presentation and T-cell recognition in the context of cancer and other diseases.
Mechanisms underlying transcriptional dysregulation, DNA damage responses, inflammation and resistance. Design theranostics targeting the cancer surface proteome and define synthetic lethal interactions.
Our overarching goal is to understand the biology of skin cancer. We use a variety of -omic approaches to delineate the genetic and transcriptomic alterations in normal and tumorigenic skin cells.
The Vasudevan Laboratory studies growth factor signaling through receptor tyrosine kinases and the Ras signaling pathway in development and cancer with an emphasis on neurofibromatosis.
