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Immunology

Micrograph of an islet from a transgenic mouse expressing green fluorescent protein (GFP) in the pancreatic islet beta cells (courtesy Qizhi Tang, PhD)The UCSF Immunology Graduate Program is a component of both the Biomedical Sciences (BMS) program and the Program in Biological Sciences (PIBS). Currently, students interested in the program are admitted into the BMS program and elect to follow the Immunology Track at the end of the first year. First year BMS students pursue coursework with an emphasis on mammalian cells and tissues, including the immune system. Modern approaches for understanding the molecular mechanisms of cell, organ, and immune system function are studied as are integrative approaches toward defining the physiological in vivo importance of these mechanisms. We believe that this coursework will provide an excellent knowledge base for graduate students with a strong interest in immunology and related fields such as infectious disease. In addition, first year students do three research "rotations" in different BMS/Immunology laboratories to learn experimental approaches hands-on and to aid them in choosing a thesis laboratory and project. For students who elect the Immunology Track, the Immunology Graduate Program provides continuing advanced training in current developments of immunology and in other aspects of modern molecular and cellular biology via a weekly immunology student/faculty journal club, an annual immunology retreat, a yearly advanced topics seminar course, and a weekly seminar series by outstanding immunologists from around the U.S. and occasionally overseas. In addition to the above courses and activities, our connection with PIBS provides our students, postdoctoral fellows and faculty with close interactions with scientists studying cell biology, genetics, biochemistry and molecular biology, developmental biology, biophysics, and neuroscience. As these fields are highly relevant to modern study of immunology, these connections enhance the education of students in the Immunology Program.

Participating Faculty
Primary Research Interest: Immunology
T-cell regulation in tolerance and immunity
Primary Research Interest: ImmunologySecondary Research Interest: Tissue/Organ Biology & Endocrinology
Cellular Dynamics of Allergic Immune Responses
Primary Research Interest: ImmunologySecondary Research Interest: Human GeneticsThe Genetic Control of Autoimmune Disease
Primary Research Interest: ImmunologySecondary Research Interest: Cancer Biology & Cell Signaling
MicroRNA regulation in the immune system
Primary Research Interest: Tissue/Organ Biology & EndocrinologySecondary Research Interest: Immunology
Extracellular matrix regulation of metabolism, pulmonary disease, and cardiovascular disease
Primary Research Interest: ImmunologySecondary Research Interest: Virology & Microbial PathogenesisInnate and adaptive immunity to viral pathogens
Primary Research Interest: ImmunologySecondary Research Interest: Tissue/Organ Biology & Endocrinology
Regulation of T-cell activation and tolerance during autoimmune and transplantation responses
Primary Research Interest: ImmunologySecondary Research Interest: Tissue/Organ Biology & Endocrinology
Intracellular Membrane Traffic: Mechanisms & Immune Function
Primary Research Interest: ImmunologySecondary Research Interest: Developmental & Stem Cell BiologyT Cell Development and Function in the Fetus and Newborn
Primary Research Interest: ImmunologySecondary Research Interest: Tissue/Organ Biology & Endocrinology
Lung Peptidases in Allergy and Host Defense
Primary Research Interest: ImmunologySecondary Research Interest: Tissue/Organ Biology & EndocrinologyImmune determinants of metabolism and regeneration
Primary Research Interest: ImmunologySecondary Research Interest: Vascular & Cardiac Biology
Regulation of allergic inflammation
Primary Research Interest: Virology & Microbial PathogenesisSecondary Research Interest: Immunology

Host-Pathogen Interactions Responsible for M. tuberculosis Virulence

Primary Research Interest: Human GeneticsSecondary Research Interest: Immunology
Genetics and epidemiology of human autoimmune disease
Primary Research Interest: ImmunologySecondary Research Interest: Virology & Microbial PathogenesisCell Migration and Interaction Dynamics underlying Humoral and Barrier Immunity
Primary Research Interest: ImmunologySecondary Research Interest: Cancer Biology & Cell SignalingRegulation of B Lymphocyte and Macrophage Function by Cell Surface Receptors
Primary Research Interest: Virology & Microbial PathogenesisSecondary Research Interest: Immunology
Bacterial host-Cell Interactions
Primary Research Interest: ImmunologySecondary Research Interest: Tissue/Organ Biology & Endocrinology

Immunopathogenesis of Asthma; Genomics of Disease

Primary Research Interest: ImmunologySecondary Research Interest: Tissue/Organ Biology & EndocrinologyMechanism Oriented Clinical Research in Airway Disease
Primary Research Interest: ImmunologySecondary Research Interest: Virology & Microbial Pathogenesis
Immunopathogenesis of HIV and malaria in childhood
Primary Research Interest: ImmunologySecondary Research Interest: Cancer Biology & Cell SignalingImmunobiology of Dendritic Cells in Disease
Primary Research Interest: Virology & Microbial PathogenesisSecondary Research Interest: Immunology
Molecular Analysis of HIV Pathogenesis
Primary Research Interest: Vascular & Cardiac BiologySecondary Research Interest: ImmunologyMetabolic Changes and the Host Response to Infection
Primary Research Interest: ImmunologySecondary Research Interest: Vascular & Cardiac BiologyLipoproteins and Immune Responses to Infection and Acute Injury
Primary Research Interest: ImmunologySecondary Research Interest: Vascular & Cardiac BiologyInnate Immune Pathways and the Endothelium in Inflammatory Critical Illness
Primary Research Interest: ImmunologySecondary Research Interest: Virology & Microbial PathogenesisMucosal immunoregulation at barrier surfaces
Primary Research Interest: Immunology
Primary Research Interest: Virology & Microbial PathogenesisSecondary Research Interest: ImmunologyImmune recognition and control of malaria
Primary Research Interest: Tissue/Organ Biology & EndocrinologySecondary Research Interest: Immunology
The Intersection between Dietary Lipids, Inflammation, and Metabolic Disease
Primary Research Interest: ImmunologySecondary Research Interest: Cancer Biology & Cell SignalingThe Immune Response in 4 Dimensions
Primary Research Interest: ImmunologySecondary Research Interest: Cancer Biology & Cell Signaling
NK cell receptors in viral immunity, tumor immunity, and autoimmunity
Primary Research Interest: ImmunologySecondary Research Interest: Virology & Microbial PathogenesisHIV Pathogenesis
Primary Research Interest: Human GeneticsSecondary Research Interest: ImmunologyIntegrated Genomic and Environmental Analysis of Inflammatory Skin Disease
Primary Research Interest: Cancer Biology & Cell SignalingSecondary Research Interest: ImmunologyMetabolism and Regulation of Nitric Oxide Bioactivity
Primary Research Interest: ImmunologySecondary Research Interest: Virology & Microbial PathogenesisThe Locksley lab is studying the foundations of allergic immunity and attempting to define the underlying processes mediated by this type of host response
Primary Research Interest: Tissue/Organ Biology & EndocrinologySecondary Research Interest: ImmunologyMechanisms of lung inflammation and injury
Primary Research Interest: ImmunologySecondary Research Interest: Cancer Biology & Cell SignalingRegulation of Intracellular Signaling in Innate Immune Cells
Primary Research Interest: Virology & Microbial PathogenesisSecondary Research Interest: ImmunologyHuman Microbiome, Chronic Inflammatory Disease
Primary Research Interest: ImmunologySecondary Research Interest: Cancer Biology & Cell SignalingUbiquitination, Cell Signaling and Immunity
Primary Research Interest: ImmunologySecondary Research Interest: Developmental & Stem Cell Biology
Tolerance induction after in utero stem cell transplantation or gene therapy
Primary Research Interest: Virology & Microbial PathogenesisSecondary Research Interest: ImmunologyCryptococcus neoformans: from model pathogen to model organism
Primary Research Interest: ImmunologySecondary Research Interest: Virology & Microbial PathogenesisLymphocyte Migration and Autoimmune Disease
Primary Research Interest: Virology & Microbial PathogenesisSecondary Research Interest: ImmunologyPathogenic Mechanisms, Treatment, and Prevention of HIV Disease
Primary Research Interest: Cancer Biology & Cell SignalingSecondary Research Interest: ImmunologyGenetic analysis of signal transduction in B cell development and leukemia
Primary Research Interest: Virology & Microbial PathogenesisSecondary Research Interest: Immunology
The Biology of Candida albicans, a Unique Fungal Commensal-Pathogen of Humans
Primary Research Interest: Virology & Microbial PathogenesisSecondary Research Interest: Immunology
Molecular Pathogenesis of HIV and Hepatitis C Virus Infections
Primary Research Interest: ImmunologySecondary Research Interest: Virology & Microbial PathogenesisMolecular biology of MHC II and HIV
Primary Research Interest: ImmunologySecondary Research Interest: Virology & Microbial Pathogenesis

Cellular immune dysfunction during persistent viral infections

Primary Research Interest: ImmunologySecondary Research Interest: Human GeneticsInherited disorders of lymphocyte development
Primary Research Interest: Cancer Biology & Cell SignalingSecondary Research Interest: Immunology
Ras Signal Transduction in Lymphocytes and Cancer
Primary Research Interest: ImmunologySecondary Research Interest: Cancer Biology & Cell SignalingRoles of biological sulfation in leukocyte trafficking and tumorigenesis
Primary Research Interest: ImmunologyDefining the cellular and molecular mechanisms of immune regulation in peripheral tissues
Primary Research Interest: Cancer Biology & Cell SignalingSecondary Research Interest: Immunology
Primary Research Interest: ImmunologySecondary Research Interest: Virology & Microbial PathogenesisMucosal Antiviral Immunity
Primary Research Interest: ImmunologySecondary Research Interest: Cancer Biology & Cell SignalingRegulation of Innate Immunity
Primary Research Interest: Human GeneticsSecondary Research Interest: ImmunologyPopulation Genetics and Human Genetics of Host Defense, Autoimmune Disease, and Diabetes
Primary Research Interest: ImmunologySecondary Research Interest: Tissue/Organ Biology & Endocrinology
In vivo function of integrins and molecular basis of lung diseases
Primary Research Interest: Immunology
Antigen presentation by dendritic cells and its role in immune tolerance and allergy
Primary Research Interest: ImmunologySecondary Research Interest: Tissue/Organ Biology & EndocrinologyThe Shum lab performs research in mouse and human models to understand basic mechanisms controlling the development of lung disease in patients with autoimmunity.
Primary Research Interest: Virology & Microbial PathogenesisSecondary Research Interest: Immunology
Regulation of cell shape and virulence by temperature in the fungal pathogen Histoplasma capsulatum
Primary Research Interest: Immunology
Regulatory T cell function and their therapeutic applications in autoimmunity and transplantation
Primary Research Interest: Virology & Microbial PathogenesisSecondary Research Interest: ImmunologyHIV Pathogenesis and lymphocyte biology
Primary Research Interest: ImmunologySecondary Research Interest: Cancer Biology & Cell SignalingAutoimmune Disease
Primary Research Interest: ImmunologySecondary Research Interest: Cancer Biology & Cell Signaling
Signal transduction in lymphocytes
Primary Research Interest: Immunology
Development of Novel Therapies for Autoimmune Diseases
Primary Research Interest: ImmunologySecondary Research Interest: Tissue/Organ Biology & EndocrinologyCellular and molecular pathogenesis of lung disease
Primary Research Interest: ImmunologySecondary Research Interest: Human GeneticsGenomics of Obstructive Lung Diseases
Primary Research Interest: Human GeneticsSecondary Research Interest: Immunology
Development of statistical methods for uncovering the genetic basis of human disease
Primary Research Interest: ImmunologySecondary Research Interest: NeurobiologyPathogenesis and immune modulation of CNS autoimmunity
Primary Research Interest: ImmunologyShaping the B cell repertoire in health and disease