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Developmental & Stem Cell Biology

Human embryonic stem cells at different stages of differentiation (photo by Heike Daldrup-Link, MD, PhD)The Biomedical Sciences Graduate Program at UCSF is home to numerous faculty members with research programs focused on fundamental questions in Developmental and Stem Cell Biology.  In addition to the focus area within BMS, a distinct Graduate Program in Developmental and Stem Cell Biology exists for those applicants who are committed to those topics (http://dscb.ucsf.edu).  This program has a more focused curriculum including coursework, seminars, and journal clubs specific to Developmental and Stem Cell Biology.  The BMS program maintains a more interdisciplinary curriculum, integrating multiple distinct focus areas with an overarching emphasis on biomedically relevant questions. 

Most Developmental and Stem Cell Biology faculty members have appointments in both programs.  Key topics of investigation among the faculty include cellular specification and differentiation, organogenesis, tissue morphogenesis and regeneration, and cell-cell signaling during development.  A variety of model systems are used to pursue relevant topics in Developmental and Stem Cell Biology, including worms, flies, fish, chickens, mice, and human-derived tissues and cells.

Participating Faculty
Primary Research Interest: Cancer Biology & Cell SignalingSecondary Research Interest: Developmental & Stem Cell BiologyGrowth factors and genetic modifiers in vascular biology and cancer
Primary Research Interest: Tissue/Organ Biology & EndocrinologySecondary Research Interest: Developmental & Stem Cell BiologySkeletal Cell Differentiation and Matrix Quality
Primary Research Interest: NeurobiologySecondary Research Interest: Developmental & Stem Cell Biology
Birth and Migration of New Neurons
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Vascular & Cardiac BiologyTranscriptional Control of Mammalian Organogenesis
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Cancer Biology & Cell SignalingMolecular basis of stem cell self-renewal, differentiation and contribution to cancer
Primary Research Interest: ImmunologySecondary Research Interest: Developmental & Stem Cell BiologyRegulation of T-cell activation and tolerance during autoimmune and transplantation responses
Primary Research Interest: Cancer Biology & Cell SignalingSecondary Research Interest: Developmental & Stem Cell BiologyRas signaling in cancer stem cells
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Cancer Biology & Cell SignalingHematopoiesis and cell signaling
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Cancer Biology & Cell SignalingSignaling control of craniofacial development and congenital disease
Primary Research Interest: NeurobiologySecondary Research Interest: Developmental & Stem Cell BiologyNeuronal/Glial Interactions that Control Myelination
Primary Research Interest: NeurobiologySecondary Research Interest: Developmental & Stem Cell BiologyWnt Signaling in Development and Function of the Mammalian Brain
Primary Research Interest: Vascular & Cardiac BiologySecondary Research Interest: Developmental & Stem Cell Biology

Receptors, Stem Cells and Pharmacology

Primary Research Interest: Developmental & Stem Cell BiologyMechanisms of Action of Peptide Hormones and Growth Factors
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Cancer Biology & Cell SignalingTransmembrane TGF-a and TGF-b Receptor Signaling in Cell Proliferation and Differentiation
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Vascular & Cardiac BiologyPlacental Biology/Bacterial Adhesion
Primary Research Interest: NeurobiologySecondary Research Interest: Developmental & Stem Cell BiologyMolecular pathways in neurodegenerative diseases
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Tissue/Organ Biology & EndocrinologyDevelopment and Biology of the Pancreatic Islets
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Tissue/Organ Biology & EndocrinologyNormal and abnormal endometrial development
Primary Research Interest: Cancer Biology & Cell SignalingSecondary Research Interest: Developmental & Stem Cell Biology
Oncogenes and Cell Cycle Control
Primary Research Interest: Developmental & Stem Cell BiologyZebrafish; development; transcription; stem cells
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Cancer Biology & Cell SignalingMolecular mechanisms of pancreas development, function and disease
Primary Research Interest: Tissue/Organ Biology & EndocrinologySecondary Research Interest: Developmental & Stem Cell BiologyHormonal and genetic regulation of human disease
Primary Research Interest: NeurobiologySecondary Research Interest: Developmental & Stem Cell BiologyMolecular Mechanisms Controlling Neuronal and Neurovascular Development
Primary Research Interest: NeurobiologySecondary Research Interest: Developmental & Stem Cell Biology

Molecular Mechanisms and Therapeutic Strategies of Neurodegenerative Diseases

Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Cancer Biology & Cell SignalingMechanisms of Hormone Action in Organ Development and Disease
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Tissue/Organ Biology & EndocrinologyMolecular Basis of Fat Cell Development and Energy Homeostasis
Control of Gene Expression
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Human GeneticsDevelopmental genetics of organ formation and regeneration
Primary Research Interest: Developmental & Stem Cell BiologyThe role of neuronal-epithelial interactions during organogenesis and regeneration
Primary Research Interest: Cancer Biology & Cell SignalingSecondary Research Interest: Developmental & Stem Cell BiologyCooperating Events in Myeloid Leukemogenesis and Their Reversal
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Human GeneticsOrganogenesis and patterning during development
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: NeurobiologyNeural Stem Cells and Embryonic Cortical Development
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Human GeneticsMolecular and cellular mechanisms of primordial germ cell development
Primary Research Interest: Developmental & Stem Cell Biology

Hematopoietic Stem Cells and Megakaryocytopoiesis

Primary Research Interest: Cancer Biology & Cell SignalingSecondary Research Interest: Developmental & Stem Cell BiologySmall RNA-mediated epigenetic and transcriptional regulation mechanisms and their implications for cancer
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: NeurobiologyEpigenetic determinants of neural stem cell fate
Primary Research Interest: NeurobiologySecondary Research Interest: Developmental & Stem Cell BiologyIdentification and characterization of stochastic choices in the nervous system
Primary Research Interest: ImmunologySecondary Research Interest: Developmental & Stem Cell Biology
Tolerance induction after in utero stem cell transplantation or gene therapy
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Tissue/Organ Biology & EndocrinologyThe Regulation of Cell Fate by Oxygen and Mitochondria
Primary Research Interest: Developmental & Stem Cell BiologyCraniofacial development, evolutionary biology, trauma, bone repair, angiogenesis
Primary Research Interest: Tissue/Organ Biology & EndocrinologySecondary Research Interest: Developmental & Stem Cell BiologyIonic Fluxes Control Keratinocyte Adhesion, Differentiation and Secretion
Primary Research Interest: Human GeneticsSecondary Research Interest: Developmental & Stem Cell BiologyNoncoding RNAs - the Dark Matter of the Genome
Primary Research Interest: NeurobiologySecondary Research Interest: Developmental & Stem Cell BiologyCortical Development and Plasticity Following Early Brain Injury
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: NeurobiologyDevelopmental Regulation, Molecular Biology and Novel Actions of Steroid/Neurosteroid Synthesis
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Vascular & Cardiac BiologyDevelopmental Regulation of Organogenesis
Primary Research Interest: Cancer Biology & Cell SignalingSecondary Research Interest: Developmental & Stem Cell BiologyTyrosine kinase signaling in cancer
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Tissue/Organ Biology & EndocrinologyEpithelial Polarity and Morphogenesis
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Tissue/Organ Biology & Endocrinology
Epithelial stem cells and cancer
Primary Research Interest: Tissue/Organ Biology & EndocrinologySecondary Research Interest: Developmental & Stem Cell BiologyProtein misfolding diseases and novel therapies
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Cancer Biology & Cell SignalingMolecular and cellular understanding of normal and leukemogenic hematopoiesis
Primary Research Interest: Cancer Biology & Cell SignalingSecondary Research Interest: Developmental & Stem Cell Biology
Development and biology of brain tumors
Primary Research Interest: NeurobiologySecondary Research Interest: Developmental & Stem Cell BiologyControl of Neural Stem Cell Fate and Migration in the Cortex
Primary Research Interest: Developmental & Stem Cell BiologyMesenchymal tissue regeneration
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Tissue/Organ Biology & EndocrinologyRegulation of Stem Cell Pluripotency and Reprogramming
Primary Research Interest: NeurobiologySecondary Research Interest: Developmental & Stem Cell Biology
Extracellular Factors Affecting Neuron Development
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Cancer Biology & Cell SignalingSignaling at the Primary Cilium, the Cell's Antenna
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Tissue/Organ Biology & EndocrinologyStem cells in lung development, maintenance and disease
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: NeurobiologyCNS Development and Disease
Primary Research Interest: NeurobiologySecondary Research Interest: Developmental & Stem Cell BiologyGenetic Regulation of Regional Specification and Differentiation in the Forebrain
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: NeurobiologyDevelopmental Genetics of the Drosophila Neuroendocrine System and Diabetes
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Tissue/Organ Biology & EndocrinologyCraniofacial Morphogenesis and Evolution
Primary Research Interest: Cancer Biology & Cell SignalingSecondary Research Interest: Developmental & Stem Cell BiologyTargeted Therapy of Hematologic Malignancies
Primary Research Interest: NeurobiologySecondary Research Interest: Developmental & Stem Cell BiologyNeural control of sexually dimorphic behaviors
Primary Research Interest: Human GeneticsSecondary Research Interest: Developmental & Stem Cell Biology
Genomic Determinants in Human Developmental Disorders
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: NeurobiologyMechanisms of axon injury, disease, and novel methods of axon repair
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Human GeneticsMolecular and Genetic Dissection of Cardiogenesis and Its Role in Human Disease
Primary Research Interest: NeurobiologySecondary Research Interest: Developmental & Stem Cell BiologyThe Role of Glia in the Formation and Function of Synaptic Circuits
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Tissue/Organ Biology & Endocrinology
The regulation of lung vascularization and development
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Cancer Biology & Cell SignalingMolecular Regulation of Mammalian Arterial Venous Specification
Primary Research Interest: Cancer Biology & Cell SignalingSecondary Research Interest: Developmental & Stem Cell BiologyThe tissue microenvironment and mechanical force in adult and stem cell fate
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Cancer Biology & Cell SignalingFunctions of the Extracellular Microenvironment in Development and Cancer
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Cancer Biology & Cell Signaling
Mechanisms of Liver Regeneration and Cancer
Primary Research Interest: Human GeneticsSecondary Research Interest: Developmental & Stem Cell BiologyPathogenesis of Human Neurogenetic Diseases
Primary Research Interest: Developmental & Stem Cell BiologySecondary Research Interest: Vascular & Cardiac BiologyDiversification of vascular lineages