Maxence Nachury, PhD

Associate Professor
Ophthalmology
+1 415 476-6758

We study the primary cilium, a surface-exposed organelle required for vision, olfaction and developmental signaling and whose dysfunction leads to obesity, skeletal malformations and kidney cysts. To decode the fundamental principles of ciliary trafficking and to understand how trafficking shapes signaling at the primary cilium, we leverage a broad expertise in biochemistry, proteomics, cell biology and in vitro reconstitution

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Human Genetics
Research Summary: 
Mechanisms of signaling and trafficking at the primary cilium, biogenesis of extracellular vesicles.

Websites

Featured Publications: 

Microtubules acquire resistance from mechanical breakage through intralumenal acetylation.

Science (New York, N.Y.)

Xu Z, Schaedel L, Portran D, Aguilar A, Gaillard J, Marinkovich MP, Théry M, Nachury MV

An Actin Network Dispatches Ciliary GPCRs into Extracellular Vesicles to Modulate Signaling.

Cell

Nager AR, Goldstein JS, Herranz-Pérez V, Portran D, Ye F, Garcia-Verdugo JM, Nachury MV

Proteomics of Primary Cilia by Proximity Labeling.

Developmental cell

Mick DU, Rodrigues RB, Leib RD, Adams CM, Chien AS, Gygi SP, Nachury MV

The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia.

Cell

Jin H, White SR, Shida T, Schulz S, Aguiar M, Gygi SP, Bazan JF, Nachury MV

A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.

Cell

Nachury MV, Loktev AV, Zhang Q, Westlake CJ, Peränen J, Merdes A, Slusarski DC, Scheller RH, Bazan JF, Sheffield VC, Jackson PK