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September 4, 2008
Speaker 1:
Justin Chen
"When iPS Cells Go All-in, a Pair Trumps 4-of-a-Kind"
Kim JB. et al. Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature 454, 646-650 (31 July 2008)
Coaches: Bill Weiss and Yadong Huang
Speaker 2: Tony Wynshaw-Boris (faculty)
"Coordination of orientation: Flamingo and the establishment of planar cell
polarity."
Chen WS. et al. Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling. Cell. 133:1093-1105. (2008)
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September 11, 2008
Speaker 1: Katie Austgen
"Putting too Much Pressure on Yourself, the Role of Autoantibodies in Pre-eclampsia"
Zhou, C.C. et al. Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice. Nat Med. 2008 Aug;14(8):855-62.
Coaches: Susan Fisher and Scott Oakes
Speaker 2: Adrian Barker
"Who ya gonna call? CLOT BUSTERS!: I ain't 'fraid of no PDGF-CC"
Su EJ. et al. Activation of PDFG-CC by tissue plasminogen activator
impairs blood-brain barrier integrity during ischemic stroke. Nat Med.
14(7):731-737 (2008).
Coaches: Harold Bernstein and Shaun Coughlin |
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September 18, 2008
Speaker 1: Nicole Byers
"A Battle of Tug of War: HIV-1 Vpu versus Tetherin"
Neil SDJ. et al. Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu. Nature Vol 451 Jan 2008.
Coaches: Melanie Ott, Eric Verdin and Warner Greene
Speaker 2: Allison Xu (faculty)
"Does fat come from muscle?"
Seale P. et al. PRDM16 controls a brown fat/skeletal muscle switch" Nature 454, 2008, 961-968. |
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September 25, 2008
Speaker 1: Ying Tan
"Old Age+Time heal all wounds"
Krizhanovsky V. et al. Senescence of Activated Stellate Cells Limits Liver Fibrosis. Cell. 134:657-667. (2008)
Coaches: Montgomery Bissell and Jody Baron
Speaker 2: Kasia Skrzypczynska
"Death by DNA: a new role for eosinophils"
Shida Y. et al. Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense. Nat Med. published online 10 August 2008.
Coaches: Rich Locksley and Joanne Engel |
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October 2, 2008
Speaker 1: Karen Ring
"In vivo Induction of Beta-Cells From Adult Pancreatic Exocrine Cells"
Zhou et al. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008.
Coaches: Yadong Huang and Michael German
Speaker 2: Pankaj Sahai
"A matter of timing: Multi-level post-transcriptional control of let-7 expression"
Agnieszka R. et al. A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat Cell. published online 6 July 2008.
Coaches: Michael McManus and Robert Blelloch |
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October 9, 2008
Speaker 1: Lionel Lim
"MicroRNAs 5’Top the Repression – in an unexpected fashion"
Orom et al. MicroRNA-10a binds the 5’ UTR of ribosomal protein and enhances their translation. Molecular Cell, 30(4), 460-471. 2008]
Coaches: Michael McManus and Andrei Goga
Speaker 2: Sachi Jain
"I'll make a neuron out of you! Generating ALS patient-specific motor neurons"
Dimos JT. et al. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science 321:1218-1221 (2008)
Coaches: Yadong Huang and Paul Muchowski
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October 16, 2008
Speaker 1: Amy Moon
"Ready, Set, Go! : Neurogenin2-regulated neuronal migration"
Heng et al. Neurogenin 2 controls cortical neuron migration through regulation of Rnd2.
Nature. 2008 Sep 455:114-118
Coaches: Tony Wynshaw-Boris and Nadav Ahituv
Speaker 2: Jeoung-Sook Shin (faculty)
"Division of labor by specific subsets of human skin dendritic cells"
Klechevsky E. et al. Functional specializations of human epidermal langerhans cells and CD14+ dermal dendritic cells. Immunity. 2008 Sep;29(3):497-510.
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October 23, 2008
Speaker 1: Angela Rojas
"No PTEN? Not so bad. FGFR2 inhibition induces cell death despite PTEN abrogation"
Byron S. et al. Inhibition of activated fibroblast growth receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation. Cancer Research 68:6902-6907 (2008).
Coaches: Linda Giudice and Jay Debnath
Speaker 2: Irina Proekt
"ER stress: just what the doctor ordered? Using a proteasome inhibitor to treat lupus."
Neubert K, et al. The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis. Nat Med. 2008 Jul;14(7):748-55.
Coaches: Tony DeFranco and Scott Oakes
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October 30, 2008
Speaker 1: Yelena Bronevetsky
"HIV: Beware who you let through the T-Cell Door this Halloween- It could be the Immunogoblin!"
Kumar, P et al. "T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice." Cell 134, 577-586. Aug 22, 2008.
Coaches: Eric Verdin and Mike McCune
Speaker 2: Leonard Chavez
"HIV-1 Utilizes Co-Receptor Signaling to Promote Pre-Integration Latency in Resting CD4+ T-Cells"
Yoder A. et al. HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells. Cell. 2008 Sep 5;134(5):782-92.
Coaches: Eric Verdin and Diane Barber |
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November 6, 2008
Speaker 1: Michael Sachs
"Expect the unexpected: Dedifferentiation as an unlikely source of adult progenitor cells during Drosophila metamorphosis"
Molly Weaver, et al. Duel Origin of Tissue‐Specific Progenitor Cells in Drosophila Tracheal Remodeling. Science. 321, 1496 (2008)
Coaches: Eric Rulifson and Holger Willenbring
Speaker 2: Joe Wiemels (faculty)
"Making sense of Polycomb marks and DNA methylation in cancer."
Gal-Yam E. et al. Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line. PNAS: September 2, 2008 vol. 105 no. 35 12979 –12984.
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November 13, 2008
Speaker 1: Raymond Ng
"Who's the GILTY party? GILT is a critical host factor for Listeria monocytogenes infection"
Singh et al. GILT is a critical host factor for Listeria monocytogenes infection. Nature 24th Sept 2008
Coaches: Anna Bakardjiev and Creg Darby
Speaker 2: Noelle Huskey
"Striking an auditory nerve: Generation of functional auditory hair cells in the mouse inner ear"
Gubbels S. et al. Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer. Nature 25 September 2008.
Coaches: Jeremy Reiter and Eric Rulifson |
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November 20, 2008
Speaker 1: Robert Judson
"This vesicle will self destruct in 30 seconds. Please make your way to the nearest exosome."
Trajkovic K. et al. Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes. Science (2008) 319, 1244.
Coaches: Keith Mostov and Robin Shaw
Speaker 2: Christopher Nelson
"Using a Light Switch in the Spinal Cord to Rescue Normal Breathing"
Alilain WJ. et al. Light-induced rescue of breathing after spinal cord injury. J Neurosci. 2008 Nov 12;28(46):11862-70.
Coaches: TBA
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November 27, 2008: Thanksgiving Holiday |
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Speaker 2: Shaun Coughlin (faculty)
"Krebs cycle intermediates are hormones?"
Toma I et al, Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney. Journal of Clinical Investigation 118(7): 2526 (2008).
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December 11, 2008
Speaker 1: Robyn Mills
"TCRswap: Meet your new tumor antigen"
Pule M. et al. Virus-specific T cells engineered to coexpress tumorspecific receptors: persistence and antitumor activity in
individuals with neuroblastoma. Nat Med. published online 2 November 2008
Coaches: Michelle Hermiston and Bill Weiss
Speaker 2: Francesca Gazzaniga
"Let's cool to time warp again! Brrrrrrrrrd song slowed by cooling Brrrrrrrrain"
Long M. et al. Using temperature to analyze temporal dynamics in the songbird motor pathway. Nature. 2008. 456: 189-194.
Coaches: Anatol Kreitzer and Michael Brainard
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December 18, 2008: Holiday (Winter Break) |
December 25, 2008: Holiday (Winter Break) |
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January 1, 2009: Holiday (Winter Break) |
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Speaker 2: Ashley Martin
"Tuberculosis takes charge of macrophage cell death: "Not so fast, apoptosis."
Gan H. et al. Mycobacterium tuberculosis blocks crosslinking of annexin-1 and apoptotic envelope formation on infected macrophages to maintain virulence Nature Immunology 9, 1189 - 1197 (2008) Published online: 14 September 2008 | doi:10.1038/ni.1654
Coaches: Scott Oakes and Anita Sil |
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January 15, 2009
Speaker 1: Kyriacos Koupparis
"NAPE"/Tuck: Getting rid of the fat"
Gillim M. et al. N-acetylphosphatidylethanolamine, a Gut Derived Circulating Factor Induced by Fat Ingestion, Inhibits Food Intake" Cell, 135, 813-824.
Coaches: Allison Xu and Holly Ingraham
Speaker 2: Barby Zeldovich
"Beard Chromodynamics in Budding Yeast"
Smukalla S. et al. FLO1 is a variable green beard gene that drives bifilm-like cooperation in budding yeast.
Cell 135, 726-737, Nov 14, 2008
Coaches: Anita Sil and Creg Darby
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January 22, 2009
Speaker 1: Amy Heidersbach
"I Demethylate with a little help from my friends: AID, Mbd4 and Gadd45 cooperate to actively Demethylate DNA"
Rai K. et al. DNA Demethylation in Zebrafish
Involves the Coupling of a eaminase,
a Glycosylase, and Gadd45. Cell 135, 1201–1212, Dec 26, 2008.
Coaches: Joe Costello and Andrei Goga
Speaker 2: Megan Salt
"Cancer Stem Cells: Are they truly one in a million?"
Quintana et al. "Efficient tumour formation by single human melanoma cells." Nature. Dec. 2008. Vol. 456:4 pp 593-598.
Coaches: Martin McMahon and Jay Debnath |
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January 29, 2009
Special Admission Day Presentation, 5:00 p.m.
Location: N-225
Speaker 1: Betsy Gray
"Another Piece to the IVIG Puzzle: Role of SIGN-R1 in Anti-Inflammatory IVIG Therapy"
Anthony R. et al. Identification of a receptor required for the anti-inflammatory activity of IVIG. PNAS December 16, 2008 vol. 105 no. 50 19571-19578.
Coaches: Lewis Lanier and Art Weiss
Speaker 2: Lily Jan (faculty)
"Song learning in sleep"
Shank S. et al. Sleep and sensorimotor integration during early vocal
learning in a songbird. Nature 2008.
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February 5, 2009
Speaker 1: Jonathan Chou
"Cell death Scribbled out!: a role for polarity genes in mammalian tumorigenesis."
Zhan L. et al. Deregulation of scribble promotes mammary
tumorigenesis and reveals a role for cell polarity
in carcinoma. Cell. 2008 Nov 28;135(5):865-78.
Coaches: Jay Debnath and Keith Mostov
Speaker 2: Daniel Bikle (faculty)
"Serotonin and the bone-gut connection"
Yadav VK et al. Lrp5 cont5rols bone formation by inhibiting serotonin systhesis in the duodenum. Cell 135:825-837, 2008
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February 12, 2009
Special Admission Day Presentation, 5:00 p.m.
Location: N-217
Speaker 1: Josie Clowney
"Oh my Gadd, get out of here! DNA demethylation?!?!?!"
Ma D. et al. Neuronal Activity–Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis. Sciencexpress. Published Online January 1, 2009.
Coaches: Robert Blelloch and Steve Finkbeiner
Speaker 2: Zena Werb (faculty)
"Lox and BMDC make a delicious niche for metastasis"
Erler JT, et al. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell
recruitment to form the premetastatic niche.
Cancer Cell. 2009 Jan 6;15(1):35-44.
PMID: 19111879
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Speaker 2: Ophir Klein (faculty)
"The battle of the bulge: where are the epithelial stem cells?"
Jaks V. et al. Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nature Genetics. published online 12 October 2008; doi:10.1038/ng.239. |
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Speaker 2: Michael Beattie (faculty)
"The scientific basis for the first FDA approved embryonic stem cell clinical trial"
Keirstead H. et al. Human embryonic stem cell-derived oligodendrocyte progenitor cell
transplants remyelinate and restore locomotion after spinal cord injury. J. Neurosci.,
25: 4694-4705 (2005).
Wadman, M. et al. Stem cells ready for prime time. Nature, 29 Jan 2009, 457: 516.
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Speaker 2: Fong Koh
"The invisible quarterback exposed! Deeply quiescent hematopoietic stem cells show up only when stressed"
Wilson et al. Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair. Cell. 2008 Dec 12; 135: 1118–1129.
Coaches: Ben Braun and Cliff Lowell
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Speaker 2: Lennart Mucke (faculty)
"New Genetic Insights into the Causes of Amyotrophic Lateral Sclerosis (ALS)" Kwiatkowski, Jr. T. J., et al. Mutations in the FUS/TLS Gene on Chromosome 16. Science 323:1205-1208 (2009)
Vance C. et al. Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6. Science 323:1208-1211 (2009) |
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March 26, 2009
NO JOURNAL CLUB
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Speaker 2: Debbie Ruelas
"Vegging out in the bone marrow niche"
Hooper AT. et al. Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell Stem Cell. 2009 Mar 6;4(3):263-74. PMID: 19265665 [PubMed - in process]
Coaches: Andy Leavitt and Nigel Killeen
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Speaker 2: Mark Moasser (faculty)
"Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle"
Zhang et al. Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle. Zhang et al, J Cell Biol 2009; 184: 785-792.
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Speaker 2: Jasmine Lau
"The Hunger Challenge: The PI3K-Activated Tumors WIN!"
Kalaany N. & Sabatini D. Tumours with PI3K activation are resistant to dietary restriction. Nature (Advanced Online Publication), Published online 11 March 2009
Coaches: Cynthia Kenyon and Andrei Goga |
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Speaker 2: Linda Noble (faculty)
"Spinal cord injury- Overcoming maladaptive behavior"
Gerzanich V. et al. De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury. Nature Medicine 15:185-191, 2009.
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Speaker 2: Jane Yu
"Getting things straight: Wnt 11 acts as a directional cue in
myocyte elongation."
Gros J. et al. WNT11 acts as a directional cue to organize the elongation of early muscle fibres. Nature 457, 589-593 (29 January 2009)
Coaches: Rich Schneider and Tamara Alliston
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May 28, 2009
Speaker 1: Ian Kratter
"A Pore Excuse for Aging"
D'Angelo MA, et al. Age-Dependent Deterioration of Nuclear Pore Complexes Causes a Loss of Nuclear Integrity in Postmitotic Cells. Cell 136, 284-295, January 23, 2009.
Coaches: Steven Finkbeiner and Creg Darby
Speaker 2: Lindsey Criswell (faculty)
"The power of DNA resequencing for identifying causative genetic variants contributing to complex human disease"
Nejentsev S, et al.Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes. Science 17 April 2009:Vol. 324. no. 5925, pp. 387 - 389
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Speaker 2: Mike Ando
"Get the MEF2 out of here: Chaperone-mediated autophagy and neuron survival"
Qian Y, et al.Regulation of Neuronal Survival Factor MEF2D by Chaperone-Mediated Autophagy. Science 323, 124 (2009)
Coaches: Jay Debnath and Bob Nussbaum
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Speaker 2: Scott Baraban (faculty)
"Better late than never: rebuilding a dysplastic cortex"
Manent JB. et al. Dcx reexpression reduces subcortical band heterotopia and seizure threshold in an animal model of neuronal migration disorder. Nature Medicine 15(1):84-90, 2009.
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Biomedical Sciences (BMS) Graduate Program
