September 6, 2007
Speaker 1: Emily Thornton
"In case of emergency, dial "CX3CR1+" on the nearest blood vessel."
Auffray, C. et al.
Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior. Science 317, 666 (2007)
Coaches: Cliff Lowell & Max Krummel

Speaker 2: Rong Wang (faculty)
"Cre-ating single somatic cell mutation in mice to trace cell lineage differentiation and to model sporadic loss of tumor suppressor genes."
Zong, H. et al. Mosiac Analysis with Double Markers in Mice. Cell, Vol. 121, 479-492, May 6, 2005.
Muzamdar, M et al. Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM). PNAS, Vol 104, 4495-4500, March 13, 2007.

September 13, 2007
Speaker 1: Yvan Chanthery
"The modern-day search for the FOUNTAIN of YOUTH: The role of Wnt signaling in aging. "
Brack, A.S. et al. Increased WNT Signaling During Aging Alters Muscle Stem Cell Fate and Increase Fibrosis. Science 317, 807 (2007).
Coaches: Bill Weiss and Zena Werb

September 20, 2007
Speaker 1: Jeff Alexander
"Stopping Short:  Histone Marks Reveal a Costanza Classic During Transcription."
Guenther, M.G. wt al. A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells. DOI 10.1016/j.cell.2007.05.042.
Coaches: Robert Blelloch and Miguel Ramalho-Santos

Speaker 2: Jon Clingan
"Interferon force: starring Chuck Norris as RNase L"
Malathi, K et al. Small self-RNA generated by RNase L amplifies antiviral innate immunity. Nature 448, 816-9 (2007).
Coaches: Mehrdad Matloubian and Mike McManus

September 27, 2007
Speaker 1: Alison Coady
"Making LOV with the Lights On! Light sensing and virulence in Brucella"
Swartz TE, et al. Blue-light-activated histidine kinases: two-component sensors in bacteria. Science. 2007 Aug 24;317(5841):1090-3.
Coaches: Anita Sil and Anna Bakardjiev

Speaker 2: Bob Nussbaum (faculty)
"Sirtuin 2 in Parkinson Disease"
Outeiro TF et al. Sirtuin 2 Inhibitors Rescue {alpha}-Synuclein-Mediated Toxicity in Models of Parkinson's Disease. Science 27 July 2007: Vol. 317. no. 5837, pp. 516 - 519

October 4, 2007
Speaker 1: Kristen Coakley
"I can't live without you: Secret affair between B cell malignancies and Hedgehogs EXPOSED"
Dierks, Christine et al. Essential role of stromally induced hedgehog signaling in B-cell malignancies. Nature Medicine 13(8): 944-951, 2007.
Coaches: Zena Werb and Jeremy Reiter

Speaker 2: Mark White
"Almost an 80's Powerballad: Partial Eclipse of the Heart"
Schoenebeck, J. J. et al. Vessel and Blood Specification Override Cardiac Potential in Anterior Mesoderm. Developmental Cell 13, 254–267, August 2007
Coaches: Deepak Srivastava and Benoit Bruneau

October 11, 2007
Speaker 1: Jen Bando
"Psoriasis: Why can’t you control yourself?"
Lande R et al. Plasmacytoid dendritic cells sensee self-DNA coupled with antimicrobial peptide. Nature 2007(online advanced publication)
Coaches: Richard Locksley and Mark Anderson

Speaker 2: Emily Elliott
"Toll-like Receptors: Not Just for Immunologists Anymore........
TLRs and Adult Neurogenesis"
Rolls A. et al. Toll-like receptors modulate adult hippocampal neurogenesis. Nat Cell Bio. 2007 Sep;9(9):1081-8.
Coach: Tony DeFranco

October 18, 2007
Speaker 1: Kegan Warner
"Keep Your Eye on the Clock: the role of circadian rhythms in the retina."
Storch, K. et al. Intrinsic Circadian Clock of the Mammalian Retina: Importance for Retinal Processing of Visual Information. Cell. DOI 10.1016/j.cell.2007.06.045.
Coach: Louis Ptacek

Speaker 2: Laura Bull (faculty)
"Did the agricultural revolution trigger evolution of enzymatically turbocharged spit? Dietary starch and copy number variation in the human amylase gene."
Perry GH. et al. Diet and the evolution of human amylase gene copy number variation. Nat Genet. 2007 Oct;39(10):1256-60. Epub 2007 Sep 9. PMID: 17828263 [PubMed - in process]
Novembre J. et al. Adaptive drool in the gene pool. Nat Genet. 2007 Oct;39(10):1188-1190.

Speaker 2: You Bin Lin
"Stopping compulsive scratching! Gastrin-releasing peptide receptor mediates itch sensation"
Yan-Gang S. et al. A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. From: Nature, Vol 448, Page 700-704
Coaches: Nigel Bunnett and Allan Basbaum

November 1, 2007
Speaker 1: Helen Hwang
"Be afraid, be very afraid: Fear enhances memory and learning"
Hu et al. Emotion Enhances Learning via Norepinephrine Regulation of AMPA-Receptor Trafficking. Cell. Vol 131 160-173, Oct 5 2007.
Coach: Allison Xu

Speaker 2: Michael Patnode
"Thymus-Specific Proteasomes: Prote-awesome"
Murata, S., et al., Regulation of CD8+ T cell development by thymus-specific proteasomes. Science, 2007. 316(5829): p. 1349-53.
Coaches: Mark Anderson and Lewis Lanier

November 8, 2007
Speaker 1: Linda Lee
"Cancer Treatment Pays Toll To the Immune System"
Apetoh L, et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med. 2007 Oct;13(9):1050-1059.
Coaches: Larry Fong and Kevin Shannon

Speaker 2: Keith Mostov (faculty)
"Blowing up a balloon."
Tsarouhas V. et al. Sequential pulses of apical epithelial secretion and endocytosis drive airway maturation in Drosophila. Dev Cell. 2007 Aug;13(2):214-25.

Speaker 2: Midori Yenari (faculty)
"Neuronal Toll-like receptors in brain ischemia"
Tang S. et al. Pivotal role of neuronal Toll-Like receptors in ischemic brain injury and functional deficits. PNAS. 2007 Aug;21(104):13798-13803.

November 29, 2007
Speaker 1: Renee VanderLaan
"Extreme Makeover: Stroma Edition - Mesenchymal stem cells and metastasis"
Karnoub, AE et al. Mesenchymal stem cells within tumor stroma promote breast cancer metastasis. Nature. 2007 Oct 4;449(7162):557-63.
Coach: Valerie Weaver

Speaker 2: Sarah Gierke
"Leukocytes Breakthrough:
Transcellular Diapedesis is Initiated by Invasive Podosomes "
Carman C. et al. Transcellular Diapedesis is Initiated by Invasive Podosomes. Immunity. 2007 Jun 14;26:784-797.
Coaches: Steve Rosen and Diane Barber
___________________________________________________________________________
Special Journal Club Presentation by Mimi Zeiger
"Preparing Your Journal Club Talk: Schedule, Structure, Slides."
Location: N-217
Time: 1 p.m. - 2 p.m.

Speaker 2: Brian Webster
"Once bitten, twice (as likely to) die: Even uninfected mosquitoes can be deadly."
Schneider B. et al. Prior Exposure to Uninfected Mosquitoes Enhances Mortality in Naturally-Transmitted West Nile Virus Infection [PLoS ONE 2(11): e1171]. 
Coach: Phil Rosenthal

December 13, 2007
Speaker 1: Justin Chen
"Flashback to 1991: Caught in the act - a side of Piwi we never knew!"
Hang Y. et al, An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster. Nature 2007. 450: p. 304-308
Coaches: Michael McManus and Robert Blelloch

Speaker 2: Creg Darby (faculty)
"Do zebrafish dream of amphibious sheep?"
Yokogawa T., et al. (2007) Characterization of Sleep in Zebrafish and Insomnia in Hypocretin Receptor Mutants. PLoS Biol 5(10): e277 doi:10.1371/journal.pbio.0050277

January 3, 2008
Speaker 1: Katie Austgen
"It's a Cell Eat Cell World, Baby!"
Overholtzer M. et al. A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell Invasion. Cell 131. 966-979. Nov 30 2007.
Coaches: Jay Debnath and Scott Oakes

Speaker 2: Linda Noble (faculty)
"Germinal matrix vascularity: A case for too young, too active, and too vulnerable"
Ballabh P. et al. Angiogenic inhibition reduces germinal matrix hemorrhage. Nat Med. 2007 Apr;13(4):477-85

Speaker 2: Feng-Yen Li
"A new weapon of a master regulator of immunity: uncovered!"
Collison LW et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function..Nature 2007 Nov 22 450(7169):566-9
Coaches: Jeff Bluestone, Qizhi Tang, Cliff Lowell

January 17, 2008
Speaker 1: Nicole Byers
"Hungry, Hungry Tregs: Cytokine deprivation-mediated apoptosis"
Pandiyan et al. CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. 2007 Nature.
Coaches: Jeff Bluestone and Mark Anderson

Speaker 2: Dorit Ron (faculty)
TBA
Paper Reference TBA

January 24, 2008
Special Admissions Day Presentation, 5:00 p.m.
Location: N-217
Speaker 1: Lauren Herl
"...and where are you from Microglia?"
Ajami B et al. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci. 2007 Dec;10(12):1538-43.
Mildner A et al. Microglia in the adult brain arise from Ly-6C(hi)CCR2+ monocytes only under defined host conditions. Nat Neurosci. 2007 Dec; 10(12): 1544-53.
Coaches: Yadong Huang and Midori Yenari

Speaker 2: Susan Fisher (faculty)
"Letting Breast Cancer Stem Cells Go: Can Pachinko Get Them Back?"
Yu F. et al. let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells. Cell. DOl 10.1016/j.cell.2007.10.054
Nagrath S. et al. Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 2007: 450;1235-1241

Speaker 2: Graeme Hodgson (faculty)
"Tumour invasion and metastasis initiated by microRNA-10b in breast cancer."
Ma L. et al. Nature. 2007 Oct 11;449(7163):682-8

February 7, 2008
Special Admissions Day Presentation, 5:00 p.m.
Location: N-225
Speaker 1: Jan Lui
"Bored of your binding partner?"
Dessaud E. et al. Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism. Nature. 2007 Nov 29;450(7170):717-20.
Coaches: Jeremy Reiter and Stavros Lomvardas

Speaker 2: Lewis Lanier (faculty)
"Guardians at the Gate"
Koebel CM. et al. Adaptive immunity maintains occult cancer in an equilibrium state. Nature. 2007 Dec 6;450(7171):903-7.

Speaker 2: Kasia Skrzypczynska
"How Shiga Stx it to ya: a novel mechanism for the uptake of a bacterial toxin."
Romer W. et al. Shiga toxin induces tubular membrane invaginations for its uptake into cells. Nature. 2007 Nov 29;450(7170):670-5.
Coaches: Torsten Wittmann and Creg Darby

Speaker 2: Robin Shaw (faculty)
"Good Communication is Essential to the Rhythm of Life"
Roell et al. “Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia” in Nature 2007:450;819-824.

Speaker 2: Pankaj Sahai
"Synapse Elimination - Compliments from the Complement Cascade"
Stevens B. et al. The Classical Complement Cascade Mediates CNS Synapse Elimination. Cell 131, 1164-1178. 2007 Dec 14.
Coaches: David Rowitch and Clifford Lowell

Speaker 2: Leonard Chavez
"Getting Punched in the GALT by HIV: No Longer a Blind-Sided Assault?"
Arthos, J. et al. HIV-1 envelope protein binds to and signals through integrin alpha-4-beta-7, the gut mucosal homing receptor for peripheral T cells. Nature Immunology 10 Feb 2008 Advance Online Publication
Coaches: Jay Levy, Warner Greene, and Steven Rosen

Speaker 2: James E. Cleaver (faculty)
"Evolutionary design of the bacterial flagellum"
Liu & Ochman, “Stepwise formation of the bacterial flagellar system” Proc Natl Acad Sci US 104:7116-7121 2007. (additional reading: The Edge of Evolution” by M. Behe ,2007).

Speaker 2: Jackie Maher (faculty)
"Fat Met Fas: unique partners in obesity-related liver disease"
Zou C, Ma J, Wang X, Guo L, Zhu Z, Stoops J, Eaker AE, Johnson CJ, STrom S, Michalopoulos GK, DeFrances MC, Zarnegar R.  Lack of Fas antagonism by Met in human fatty liver disease.  Nature Medicine 2007;Sep 13(9):1078-1085.

Speaker 2: Irina Proekt
"A cytokine's TENacious grip: IL-27 curbs inflammation via IL-10"
Stumhofer J. et al. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nature Immunology 8, 1363 - 1371 (2007)
Coaches: Scott Zamvil and Lewis Lanier

Location: HSW-301

Speaker 2: Mehrdad Matloubian (faculty)
"TANKs for the memories" - TBK1's role in making DNA vaccines
effective (at least in mice)"
Ishii, et al. TANK-binding kinase-1 delineates innate and adaptive immune
responses to DNA vaccines. Nature 2008, 451:725.

Location: HSW-301

Speaker 2: Michael Sachs
"A Beta Cell in Never-Never-Land: How to Make 'em Grow Up"
Kroon E. et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol. 2008 Feb 20; [Epub ahead of print]
Coaches: Michael German and Holger Willenbring

Location: HSW-301

Speaker 2: John Fike (faculty)
"TBA"
Paper Reference TBA

Location: HSW-301

Speaker 2: Josie Clowney
"LSD-1 causes chromosome makeout party in the nucleus"
Nunez E. et al. Nuclear receptor-enhanced transcription requires motor- and LSD1-dependent gene networking in interchromatin granules. Cell, March 21, 2008.
Coaches: Stavros Lomvardas and Eric Rulifson

Location: HSW-301

Speaker 2: Francesca Gazzaniga
"Britney Spears Pregnant Again: How conscious of our decisions are we? "
Soon C.S. et al. Unconscious determinants of free decisions in the human brain. Nature. 21 March; published online 13 April 2008; doi:10.1038/nn.2112.
Supplementary Information
Coaches: Adam Gazzaley and Michael Stryker

Location: HSW-301

May 29, 2008
Speaker 1: Renatta Knox
"Towards a Molecular Understanding of the Autisms"
Katsuhiko Tabuchi, et al. A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice. Science 318, 71 (2007);DOI: 10.1126/science.1146221.
Jamain S. et al. Reduced social interaction and ultrasonic communication in a mouse model of monogenic hertiable autism. PNAS 2008;Feb 5(105):1710-1715.
Coaches: Erik Ullian and Hilary Beggs

Speaker 2: Douglas Nixon (faculty)
"Dendritic cells deliver a poisoned chalice - HTLV-1 virus gets a free ride"
Jones KS. et al. Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4(+) T cells. Nat Med. 2008 Apr;14(4):429-36. Epub 2008 Mar 23.

Location: HSW-301

Speaker 2: David Gardner (faculty)
"CaMKII – A multi-tasking kinase linked to cardiac dysfunction."
Erickson J.R. et al. A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation. Cell 133: 462-474, 2008

Location: HSW-301

Speaker 2: Kyriacos Koupparis
"Bees, Geese and Zebras - Can You See a Pattern?"
Martin Loose et.al. Spatial regulators for bacterial cell division self-organize into surface waves in vitro. Science 320, 789-92 (2008)
Coaches: Orion Weiner and Linda Brinen

Location: HSW-301