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2006-07 BMS Journal Club
Thursdays, 12:00 Noon
Location: N225, Parnassus
Videoconferenced to Mission Bay, Room GH-S271,
SFGH Lung Biology Conference Room Bldg 1, enter through 150

Date Speaker #1 Speaker #2
9/7/2006 Will Schachterle (student)
"The Fab Four Induce Pluripotency"
K. Takahashi et al. Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors Cell 126, 1-14, August 25, 2006.
Faculty Coaches: Miguel Ramalho-Santos and Robert Blelloch 		Kevin Shannon (faculty)
"A Stem Cell Nevermore... or Not "
A. Krivtsov et.al. Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature 442, 818-822, August 17 2006.
E. Passegué. A game of subversion. Nature 442, 754-755, August 17 2006.
9/14/2006 Collin Melton (student)
"Stepping it up a Notch: the role of Notch signaling in stem cell maintenance"
A. Androutsellis-Theotokis et. al. Notch signalling regulates stem cell numbers in vitro and in vivo. Nature. 2006 Aug 17;442(7104):823-6. Epub 2006 Jun 25.
Faculty Coaches: Susan Fisher and Robert Blelloch		 Beth Theusch (student)
"Genomic flipping leads to skipping "
Shaw-Smith et al. Microdeletion encompassing MAPT at chromosome 17q21.3 is associated with developmental delay and learning disability. Nat Genet. 2006 Aug 13; [Epub ahead of print]
Sharp et al. Discovery of previously unidentified genomic disorders from the duplication architecture of the human genome. Nat Genet. 2006 Aug 13; [Epub ahead of print]
Koolen et al.. A new chromosome 17q21.31 microdeletion syndrome associated with a common inversion polymorphism. Nat Genet. 2006 Aug 13; [Epub ahead of print]
Faculty Coaches: Jane Gitschier and John Witte
9/21/2006 Cristina Penaranda (student)
“The toll of nuclear attack”
Pisitkun P. et al. Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication.
Science. 2006 Jun 16;312(5780):1606-8.
Faculty Coaches: Mark Anderson and Mehrdad Matloubian		 Robert Blelloch (faculty)
"Insulating Silence"
Lei et al. RNA interference machinery influences the nuclear organization of a chromatin insulator. Nature Genetics. August 2006. 38: 936-941.
9/28/2006 Michelle Toft (student)
"The softer side of NK cells"
Hanna J et al. Decidual NK cells regulate key developmental processes at the human fetal-maternal interface. Nat Med. 2006 Aug 6; [Epub ahead of print]
Faculty Coaches: Lewis Lanier and Susan Fisher		 Jesse Green (student)
"The latest to embrace the so-called 'softer side' movement, mast cells stage march and rally to promote tolerance"
Lu et al. Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature. 2006 Aug 31;442(7106):997-1002
Faculty Coaches: Rich Locksley and George Caughey
10/5/2006 April Price (student)
"Dr. Jekyll and Mr. Hyde: the many faces of p40."
Langowski et al. IL-23 promotes tumor incidence and growth. Nature. 2006 July 27. 442(7101):461-5.
Faculty Coaches: Lewis Lanier and Doug Hanahan 		Bill Weiss (faculty)
"Take two of these and see me in the morning:  neuronal guidance molecules as a therapy for neurovascular disease."
Wilson et al. Netrins promote developmental and therapeutic angiogenesis. Science. 2006 Aug 4;313(5787):640-4.
10/12/2006 Wanda Kwan (student)
"Breaking the Dance"
Graham et al. Cleavage at the Caspase-6 Site Is Required for Neuronal Dysfunction and Degeneration Due to Mutant Huntingtin. Cell 125, 1179-1191, June 16, 2006.
Faculty Coaches: Paul Muchowski and Steve Finkbeiner		 Alana Lerner (student)
"Have Some Tequila!"
Didelot, et al. Tequila, a neurotrypsin ortholog, regulates long term memory in drosphila. Science. 11 August 2006. 313:851.
Faculty Coaches: Steve Finkbeiner and Fen Biao Gao

 
10/19/2006 Davina Wu (student)
"Contagious Cancer Cells: Clues from Man's Best Friend"
Murgia et al. Clonal origin and evolution of a transmissible cancer. Cell. 2006 Aug 11;126(3):477-87.
Faculty Coaches: Kevin Shannon and Don Ganem
 Gabriele Bergers (faculty)
"If you cast out one spirit, seven return: Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors"
Yuval Shaked et al. Science 2006 Sep 22; 313(5794): 1785-7.
10/26/2006 Melissa Ehlers (student)
"I'm N' FAT, I'm big-boned"
Heit et al. Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function. Nature. 2006 Sep21;443(7109):345-9.
Faculty Coaches: Mike German and Allison Xu 		Lisa Kelly (student)
"Snakes on a Mast Cell"
Metz et al. Mast cells can enhance resistance to snake and honeybee
venoms. Science. 2006 Jul 28;313(5786):526-30.
Faculty Coaches:George Caughey and Jason Cyster
11/2/2006
Angela Sia (student)
"You think you know, but you have no idea: New insight on BACE1 knockout"
Willem et al. Control of peripheral nerve myelination by the beta-secretase BACE1. Science. 2006
Faculty Coaches: Peter Ohara and Eric Ullian
11/9/2006 Marine Champsaur (student)
"Feeling exhausted? Forget caffeine, block that PD-1!"
PD-1 expression on HIV-specific T cells is associated with T-cell
exhaustion and disease progression.
Nature. 2006 Sep 21;443(7109):350-4.
Faculty Coaches: Mehrdad Matloubian and Lewis Lanier		 Nicole Santos (student)
"Alright... Stop, Activate and Listen"
Bao et al. Glioma stem cells promote radioresistance by preferntial activiation of the DNA damage response. Nature 2006.
Faculty Coaches: Gerard Evan and Robert Blelloch
11/16/2006 Shuyi Zhang (student)
"A Plague on Both Your LPS Variants"
Montminy SW et al.  Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response.  Nature Immunology 2006.
Faculty Coaches: Creg Darby and Tony DeFranco
Benoit Bruneau (faculty)
"Turn left, no, right, no, left! That's it, left."
Nakamura et al., Generation of robust left-right asymmetry in the mouse embryo requires a self-enhancement and lateral-inhibition system. Dev Cell. 2006 Oct;11(4):495-504
11/23/2006 Holiday (Thanksgiving)
11/30/2006 Journal Club will not be held this week. Instead, BMS presents a Special Seminar:

Dr. Bruce Conklin
The Gladstone Institute
"Functional Genomics, Stem Cells and Pharmacology"

Hosted by Robert Nussbaum
Division of Medical Genetics
12/7/2006 Bethann Hromatka (student)
"3 blind mice, see where they run?"
MacLauren et at., Retinal repair by transplantation of photoreceptor precursors. Nature 444 , 203-207 (9 November 2006)
Faculty Coaches: David Copenhagen, Doug Gould, and Matthew LaVail
 Nga Bien-Ly (student)
"Red, red wine, you make me feel so fine"
Baur et al., Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444. 337-342. Nov 16, 2006.
Faculty Coaches: Robert Farese and Yadong Huang
12/14/2006 Emmanuelle Passegue (faculty)
"If they don't stick, they don't stay"
Jin et al. Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med. 2006 Oct;12(10):1167-74. Epub 2006 Sep 24.
Krause etal. Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells. Nat Med. 2006 Oct;12(10):1175-80. Epub 2006 Sep 24.





12/21/2006 Holiday (Winter Break)
12/28/2006 Holiday (Winter Break)
1/4/2007 Julie Gaulden (student)
"Follow the Pancreatic Road"
K. D'Amour et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol. 2006 Nov;24(11):1392-401.
Faculty Coaches: Mike German & Didier Stanier
 
1/11/2007 Yun Choi (student)
"How can you mend a broken heart "
R. Kanadia et al. Reversal of RNA missplicing and myotonia after muscleblind over expression in a mouse poly(CUG) model for myotonicdystrophy. PNAS 2006;103;11748-11753. July 24.
M. Mahadevan et al. Reversible model of RNA toxicity and cardiac conduction defects in myotonic dystrophy. Nature 2006;10;1038;1066-1070. July 30.
Faculty Coaches: Ying-Hui Fu & Robin Shaw
Emily Gogol (student)
"Blighted Beans:  A Taste of Evolution"
A. Ptiman et al. Exposure to host resistance mechanisms drives evolution of bacterial virulence in plants. Current Biology, Vol 15. 2230-2235. Dec 20, 2005.
Faculty Coaches: Jeff Cox & Anita Sil
1/18/2007 Lilly Radoshevich (student)
"Baby Got Bac.! "
P. Turnbaugh et al. An obesity-associated gut microbiome with increased capcity for energy harvest. Nature. 2006 Dec 28;444(5414):21-28.
R. Ley et al. Human guy microbes associated with obesity. Nature. 2006 Nov 10;444(4441022a):1023.
Faculty Coaches: Joanne Engel & Bob Farese

Special Journal Club Presentation with Mimi Zeiger
"PREPARING A JOURNAL CLUB TALK: Schedule, Structure, Slides"
1pm -2 pm (N-217)
Nikki Reyes (student)
"Hit Me Baby, One More Time: MDMX Amplification in Retinoblastoma"
N. Laurie et al. Inactivation of the p53 pathway in retinoblastoma. Nature. 2006 Nov 2;444(7115):61-6.
Faculty Coaches: Gerard Evan & Martin McMahon
1/25/2007
Admissions Day special time: 5pm
2/1/2007
Rachel Jacks (student)
"Planting the Seeds of Alzheimer's Disease"
M. Meyer-Luehmann et al. Exogenous Induction of Cerebral B-Amyloidogenous is Governed by Agent and Host. Science 2006;1781-1784. Sept. 22.
Faculty Coaches: Marc Diamond & TBA
Stacyann Forrester (student)
"Found: A bipotential progenitor for the cardiac lineage "
S. Wu et al. Developmental Origin of a Bypotential Myocardial and Smooth Muscle Cell Precursor in the Mammalian Heart. Cell 2006;1137-1150. Dec. 15.
Faculty Coaches: Harold Bernstein & Benoit Bruneau
2/8/2007
Admissions Day special time: 5pm
location for this event only:
N-217, Parnassus
Morgan Truitt (student)
"Calling ahead for reservations- a table for tumor."
S. Hiratsuka et al. Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis; Nat Cell Biol. 2006 Dec;8(12):1369-75.
Faculty Coaches: Gabriele Bergers and Gerard Evan
2/15/2007
Jonathan Esensten (student)
"A new human genetic disease linking aging, DNA damage, and the growth hormone axis"
L. Niedernhofer et al. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature. 2006 Dec 21;444(7122):1038-43.
Faculty Coaches: James Cleaver and Michael German
Brian Gilliss (student)
"The long and winding road: reactive oxygen species mask the relationship between mitochondrial genotype and phenotype."
R. Moreno-Loshuertos et al. Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants.
Nat Genet. 2006 Nov;38(11):1261-8. Epub 2006 Oct 1.
Faculty Coach: Bob Farese
2/22/2007
Jennifer Giampaolo (student)
"Interferon gamma Inhibition: Tales of the LIVING"
Park-Min et al.  FcgammaRIII-Dependent Inhibition of Interferon-gamma Responses Mediates Suppressive Effects of Intravenous Immune Globulin.  Immunity January 2007; 26: 67-78.
Faculty Coaches: Mark Anderson and Lewis Lanier
3/1/2007
3/8/2007
Emily Thornton (student)
"If you were a plasmacytoid dendritic cell, would you eat yourself?"
H Lee et al. Autophagy-Dependent Virla Recognition by Plasmacytoid Dendritic Cells. Sciencexpress. 2007 Feb 1(1136680): 1-8.
Faculty Coaches: Jay Debnath and Larry Fong
Jeff Alexander (student)
"Crouching rodent, hidden mutation: The role of CD38 in oxytocin levels and social behaviors"
D. Jin et al. CD38 is critical for social behaviour by regulating oxytocin secretion. Nature. 2007 Feb 7(5526): 1-5.
Faculty Coaches: Linda Noble and Jeremy Reiter
3/15/2007
Marcus Zachariah (student)
"Staying Alive: Maintenance of Hematopoietic Stem Cells by SDF-1 Chemokine Signaling"
"Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4
chemokine signaling in bone marrow stromal cell niches" by Sugiyama T,
Kohara H, Noda M, Nagasawa T (Immunity 2006 Dec;25(6):977-88).
Faculty Coaches: Jason Cyster and Emmanuelle Passegue
Arif Hussain (student)
"Hey QT[L]! What's your number?"
Y. Liang et al. The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice. Nat Genet. 2007 Feb;39(2):178-88.
Faculty Coaches: Brian Black and Kevin Shannon
3/22/2007
Armando Lemus (student)
"Destruction of the Lung by the PVL Toxin"
Labandeira-Rey et al. Staphylococcus aureus Panton-Valentine Leukocidin Causes Necrotizing Pneumonia. Science. 2007 Feb 23(315): 1130-1133.

Faculty Coaches: Paul Sullam and Creg Darby
3/29/2007
Jon Clingan (student)
"Not your average Flintstones vitamin: vitamin D primes T cell epidermotropism"
Sigmundsdottir et al. DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27. Nat Immunol March 2007; 8: 285-293. Epub 2007 Jan 28.
Faculty Coaches: Lawrence Fong and Jason Cyster
 Seth Bechis (student)
"To be or notch to be: regulation of tip cell formation in sprouting angiogenesis"
M. Hellstrom et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature. 2007 Feb 15;445(7129):776-80. Epub 2007 Jan 28.
PMID: 17259973 [PubMed - in process]

Faculty Coaches: Susan Fisher and Rong Wang
4/5/2007
Alison Coady (student)
"Reach Out and Touch Someone:  Cell-to-Cell Retroviral Transmission"
Sherer et al. Retroviruses can establish filopodial bridges for efficient cell-to-cell transmission. Nature Cell Biology. 2007 January;9(3):310-315.
Faculty Coaches: Jeff Cox and Warner Greene
Linda Lee (student)
"Enough about Arp2/3: Formin a new view on T cell polarity"
Gomez TS, et al. Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. Immunity. 2007 Feb;26(2):177-90.
Faculty Coaches: Max Krummel and Diane Barber
4/12/2007
Mark White (student)
"If I go there will be trouble: The Clash between HIV-1 and miRNAs"
R Triboulet et al. Suppression of MicroRNA-Silencing Pathway by HIV-1 During Virus Replication. 16 October 2006; accepted 13 February 2007 Published online 22 February 2007; 10.1126/science.1136319
Faculty Coaches: Warner Greene and Andrei Goga
4/19/2007
Emily Elliott (student)
"I forgot to remember......DNA methyltransferase is required for memory formation"
C. A. Miller and J. D. Sweatt. Covalent Modification of DNA Regulates Memory Formation. Neuron. 2007 Mar 15;53(6):857-69.
Faculty Coaches: Steve Finkbeiner and Robert Blelloch
You Bin Lin (student)
"This smell is killing me! Olfaction regulates aging in Drosophila"
Libert et al. Regulation of Drosophila Life Span by Olfaction and Food-Derived Odors. Science 23 February 2007; 315: 1133-1137
Faculty Coach: Eric Rulifson and Katja Brueckner
4/26/2007 Helen Hwang (student)
"The Canine X(Small) Factor"
Nathan B. Sutter et al. A Single IGF1 Allele Is a Major Determinant of Small Size in Dogs. Science 316, 112 (2007)
Faculty Coaches: Laura Bull and Steve Hamilton
5/3/2007
Kegan Warner (student)
"Grab n' Go: EMT Transcriptional Control"
Venkov CD. et al. A proximal activator of transcription in epithelial-mesenchymal transition. J Clin Invest. 2007 Feb;117(2):304-6.
Faculty Coaches: Hal Chapman and Rik Derynck
Annie Arguello (student)
"So that explains my brain dysfunction: Stress reduces cell survival in adult neurogenesis"
Rosanne M. et al. Acute Psychosocial Stress Reduces Cell Survival in Adult Hippocampal Neurogenesis without Altering Proliferation. Journal of Neuroscience, March 14, 2007 27(11):2734-2743
Faculty Coaches: Rich Schneider, Arturo Alvarez-Buylla, and Ben Cheyette
5/10/2007
Michael Patnode (student)
"You can't leave the apoptable until you clear your platelets."
Mason KD et al. Programmed Anuclear Cell Death Delimits Platelet Life Span. Cell 128:1173-1186.
Faculty Coaches: Andy Leavitt and Jay Debnath
Kate Nestor (student)
"Rays today, raisins tomorrow: p53 serves as a sensor for UV pigmentation"
Cui, R. et al.(2007). Central role of p53 in the suntan response and pathologic hyperpigmentation. Cell. 128, 853-864.
Faculty Coach: James Cleaver and David Stokoe
5/17/2007
Sarah Gierke (student)
"Pumping Iron: Staphylococcus aureus responds to host heme and modulates virulence"
A Staphylococcus aureus Regulatory System that Responds to Host Heme and Modulates Virulence Torres et al. Cell Host & Microbe 1, 109-119, April 2007.
Faculty Coaches: Jeff Cox and Joanne Engel
Matt Wheeler (student)
"I get knocked down, but I get up again: suppression of microRNA processing enhances cellular transformation"
Kumar, M.S. et al. Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet (2007).
Faculty Coaches: Robert Blelloch and Gerard Evan
5/24/2007
Jen Bando (student)
"Where arrr me Peyerate's Patches? RET signaling regulates Peyer's patch organogenesis."
Veiga-Fernandes H. et al. Tyrosine kinase receptor RET is a key regulator of Peyer's Patch organogenesis. Nature 446: 547-551. (2007)
Faculty Coaches: Jason Cyster and Max Krummel
Shan Zhang (student)
"Sema3a heart's got funky rhythm!"
Masaki I. et al. Sema3a maintains normal heart rhythm through sympathetic innervation patterning. Nature Medicine8 April 2007; | doi:10.1038/nm1570.
Faculty Coaches: Deepak Srivastava and Takashi Mikawa
5/31/2007
Jan Lui (student)
"The blastomeres in the embryo go round and round..."
Y. Kurotaki et al. Blastocyst Axis Is Specified Independently of Early Cell Lineage But Aligns with the ZP Shape. Science DOI 0.1126/science.1138591.
Faculty Coaches: Susan Fisher and Eric Rulifson
Cathy Collins (student)
"Adaptive asymmetry: Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses"
Chang J.T. et al. Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science 315: 1687-1691.
Faculty Coaches: Nigel Killeen and Eric Brown
6/7/2007
Corey Miller (student)
"A Spoonful of Sugar Makes the Medicine Go Down: The Story of Anti-Inflammatory IgG"
Kaneko Y. et al. Anti-inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation.  Science 2006 313:670-673.
Faculty Coaches: Mike McCune and Ed Goetzl
Renee Vanderlaan (student)
"Ze effex of Zfx: Controlling self-renewal in embryonic and hematopoietic stem cells"
Galan-Caridad J.M. et al. Zfx controls the self-renewal of embryonic and hematopoietic stem cells. Cell. 2007 Apr 20;129(2):345-57.
Faculty Coaches: Miguel Ramalho-Santos and Robert Blelloch
6/14/2006
Joyce Hu (student)
"ERp5 Scissorhands: ERp5-mediated cleavage of stress ligands on tumor cells and the inhbition of NK cell activation"
B. Kaiser et al. Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands. Nature advance online 9 May 2007 doi:10.1038/nature05768.
Faculty Coach: Hal Chapman
Brian Webster (student)
"Ribosomes Running Red Lights: PTC124 allows nonsense mutation readthrough"
Welch E. et al. PTC124 targets genetic disorders caused by nonsense mutations Nature 447: 87-91 (3 May 2007).
Faculty Coaches: Alan Verkman and Robin Shaw


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