Date |
Student Speaker |
Faculty/Student Speaker |
| 9/15/05 |
Courtney Brown
" A joint a day will keep the cardiologist away: THC and its effects on atherosclerosis "
Steffens et al., Nature 434: 782-528. 4/28/2005.
Faculty Coaches: Jacqueline Maher & Israel Charo |
Susan Fisher (faculty)
"Everything Stems From The Placenta"
Gekas et al. Developmental Cell, Vol. 8, 365–375, 3/2005 &
Ottersbach et al. Developmental Cell, Vol. 8, 377–387, 3/2005. |
| 9/22/05 |
Nathan Hunkapiller
"Get rid of unsightly veins"
Transcription factor regulates vein identity. You et al.,
Nature. 5;435(7038):98-104.
May 2005
Faculty Coaches: Rong Wang & Susan Fisher |
Hilary Beggs (faculty)
"Live from the Cell: It's Real Time Signaling!"
Visualizing the mechanical activation of Src. Wang, Y. et al, Nature (2005) 434: 1040-1045 |
| 9/29/05 |
Bess Frost
"Sizing Up Your Mate"
Hammock et al., Microsatellite instability generates diversity in brain and sociobehavioral traits. Science. 2005 Jun 10;308(5728):1630-4..
Faculty Coaches: Marc Diamond & Louis Ptacek
|
Jay Debnath (faculty)
"Do double membrane vacuoles spread the common cold? Using Autophagosomes For Virus Replication"
Jackson et al., Subversion of cellular autophagosomal machinery by RNA viruses.PLoS Biol. 2005 May;3(5):e156. |
| 10/6/05 |
Marina Kolesnichenko
"Some say the world did start in fire,
Some say on ice.
And some say -- in myristoleate vesicles"
Chen et al., RNA catalysis in model protocell vesicles. J Am Chem Soc. 2005 Sep 28;127(38):13213-9. & Sacerdote et al Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose. PNAS 2005 Apr 26;102(17):6004-8. & Szostak JW. & Ricardo et al Borate minerals stabilize ribose. Science. 2004 Jan 9;303(5655):196.
Faculty Coaches: Alan Frankel & David Stokoe |
Matthias Wabl(faculty)
"Getting old to not die young"
Collado et al. Tumour biology: senescence in premalignant tumours. Nature. 2005 Aug 4;436(7051):642. & Chen et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature. 2005 Aug 4;436(7051):725-30. & Michaloglou BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature. 2005 Aug 4;436(7051):636-7 & Braig et al Oncogene-induced senescence as an initial barrier in lymphoma development. Nature. 2005 Aug 4;436(7051):660-5. |
| 10/13/05 |
Pooja Agarwal
"It's hard to stomach...without Barx1"
Kim et al.,
The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling. Developmental Cell, Vol. 8, 611-622, April, 2005
Faculty Coaches: Matthias Hebrok & Miguel Ramahlo-Santos |
David Copenhagen (faculty)
"Double Vision: Two visual systems in each eye".
Sekaran S, et al., Melanopsin-dependent photoreception provides earliest light detection in the mammalian retina.
Curr Biol. 2005 15:1099-107. |
| 10/19/05 |
Lecture by Mimi Zeiger - 5pm N-225
"Preparing a Good Journal Club Talk: Schedule, Structure, Slides" |
| 10/20/05 |
Elizabeth Mack
"Help! My baby is an alien! Understanding tolerance to foreign antigens within the context of pregnancy"
Matsuoka et al. Fetal tolerance to maternal antigens improves the outcome of allogeneic bone marrow transplantation by a CD4+CD25+ T cell-dependent mechanism.
Blood. 2005 Sep 8
Faculty Coaches: Susan Fisher & Mike McCune |
Eric Verdin (faculty)
"A Toll order for mitochondria: protection against viral infection"
Seth et al. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.Cell. 2005 Sep 9;122(5):669-82. |
| 10/27/05 |
Larry Shiow
“Not Just Digesting Journal Club Pizza: Apolipoproteins in Lipid Antigen Presentation" Van den Elzen P et al. Apolipoprotein-mediated pathways of lipid antigen presentation. Nature (2005) 437(7060):906 .
Faculty Coaches: Jason Cyster &
Hal Chapman |
Philip Coffino (faculty)
“Some assembly required (just toss any leftover pieces in the trash)”
Chen, J, Archer, TK. Regulating SWI/SNF Subunit Levels via Protein-Protein Interactions and Proteasomal Degradation: BAF155 and BAF170 Limit Expression of BAF57. Mol Cell Biol. (2005) 25:9016-27. |
| 11/3/05 |
Julia Gilden
"Lipids, Levels and Lupus: How FcgRIIb functions in SLE
Floto"
Floto
RA, Clatworthy MR, Heilbronn KR, Rosner DR, Macary PA, Rankin A, Lehner PJ, Ouwehand WH, Allen JM, Watkins NA, Smith KG. Loss of function of a lupus-associated FcgammaRIIb polymorphism through exclusion from lipid rafts. Nat Med. 2005 Oct;11(10):1056-8. &
McGaha TL, Sorrentino B, Ravetch JV. Restoration of tolerance in lupus by targeted inhibitory receptor expression.
Science. 2005 Jan 28;307(5709):590-3. Faculty Coaches: Art Weiss & Tony DeFranco
|
Hiten Madhani (faculty)
"Sensing nitric oxide: the GAF domain takes the spotlight"
D'Autreaux et al.
A non-haem iron centre in the transcription factor NorR senses nitric oxide.
Nature. 2005 Sep 29;437(7059):769-72. (2005) Nature 437, 769 |
| 11/10/05 |
Jaime Lopez
"Say hello to my little friends...the type III secretion system"
Yukihiro Akeda & Jorge E. Galan. Nature. Chaperone Release and unfolding of substrates in type III secretion. Vol. 437. 6 Oct. 2005. 911-915
Faculty Coaches: Jeff Cox & Hilary Beggs |
Paul Muchowski (faculty)
“Size DOES matter: Genes Evolving to Control Brain Size in Humans ”
Mekel-Bobrov N et al. Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens. Science. 2005 Sep 9;309(5741):1720-2. & Evans PD et al. Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans. Science. 2005 Sep 9;309(5741):1717-20. |
| 11/17/05 |
Amy Young
"BRCA killer, Qu'est que c'est? PARP PARP PARP...."
Bryant, et al. Specific killing of BRCA2-deficient tumours with inhbitors of poly(ADP-ribose) polymerase Nature. Volume 434:913.14 April 2005.
Faculty Coach: James Cleaver
|
Patrick Murphy
"Gone with the Wnt: Vascular Regression in the Eye"
Lobov IB et al
WNT7b mediates macrophage-induced programmed cell death in patterning of the
vasculature.
Nature. 2005 Sep 15;437(7057):417-21.
Faculty Coaches: Rong Wang, Nancy Boudreau & Tony DeFranco |
| 11/24/05 |
Thanksgiving Holiday |
| 12/1/05 |
Kelly Haston
"Bonads"
Johnson J et al. Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood. Cell. 2005 Jul 29;122(2):303-15.
Faculty Coaches: Cliff Lowell & Richard Weiner |
Ray Swanson (faculty)
“Sex and fire: PARP is a perp ”
Gender differences in the endotoxin-induced inflammatory and vascular responses: potential role of poly(ADP-ribose) Polymerase activation. Mabley et al., J. Pharm. Exp. Therap. 315:812-820, 2005 |
| 12/8/05 |
Landys Lopez Quezada
"The W Team: Taking on Mosquitoes One Generation at a Time"
Sinkins SP et al Wolbachia variability and host effects on crossing type in Culex mosquitoes.
Nature. 2005 Jul 14;436(7048):257-60. &
Xi Z, Khoo CC, Dobson SL. Wolbachia establishment and invasion in an Aedes aegypti laboratory population. Science. 2005 Oct 14;310(5746):326-8
|
|
| 12/15/05 |
Angell Shieh
Staying alive: Myc mutants escape oncogene-induced apoptosis
Hemann MT, et al. Evasion of the p53 tumor surveillance network by tumor-derived MYC mutants. Nature. 2005 Aug 11; 436(7052):807-11.
Faculty Coach: Bill Weiss
|
Martin McMahon
Preparing the soil for the seed.
The role of bone marrow cells in cancer metastasis.
Kaplan, R. N. et al.VEGFR1-positive haematopoietic bone
marrow progenitors initiate the
pre-metastatic niche. Nature 438, 820-827 (2005). |
| 12/22/05 |
Holiday Break |
| 12/29/05 |
Holiday Break |
| 1/5/06 |
Rebecca Doctors
"Hearing Genetic Voices"
Millar JK et al.
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling.
Science. 2005 Nov 18;310(5751):1187-91.
Faculty Coaches:
Fen-Biao Gao, Dorit Ron |
Elizabeth Szyleyko
"Malaria: What you don't knob might hurt you"
Fairhurst, M. et al.Abnormal display of PfEMP-1 on erythrocytes
carrying haemoglobin C may protect against malaria. Nature Vol 435|23 June 2005
Faculty Coaches: Jim McKerrow & Linda Brinen |
| 1/12/06 |
Daniel Garcia
"p53 wars: Slug vs Puma"
Wu, W et al. Slug Antagonizes p53-Mediated Apoptosis of Hematopoietic Progenitors by Repressing puma Cell, Vol 123, 641-653, 18 November 2005
Faculty Coaches: Martin McMahon and Gerard Evan |
Trinna Cuellar
"Relax...Don't do it....When you want to go to it
(Stress induces release of an RNA from the nucleus)"
Prasanth KV, et al (2005).
Regulating gene expression through RNA nuclear retention. Cell. Oct 21;123(2):249-63.
Faculty Coaches: Michael German & Michael McManus |
| 1/19/06 |
Alana Lerner
"Hunting for a neuron killer: it's p53!"
Bae, BI et al. p53 Mediates Cellular Dysfunction and Behavioral Abnormalities in Huntington's Disease Neuron. 2005 July 7, 47(1):(29-41)
Faculty Coaches: Jay Debnath and Paul Muchowski
|
Scott Oakes (faculty)
"A new role for BCL-2: Controlling how big guts eat little guts".
Pattingre S et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell. 2005 Sep 23;122(6):927-39.
|
1/26/06
4pm Journal Club |
|
Gerard Evan (faculty)
"Eating your heart out: the terrible extent of self-abuse in hungry cells"
Vabulas RM and Hartl FU (2005). Protein synthesis upon acute nutrient restriction relies on proteasome function.Science 310 :1960-3. |
| 2/2/06 |
Rebecca Lock
"Its NOT a beautiful day in the neighborhood; loss of p53 in tumor associated mesenchyme". Hill, R.et al. Selective Evolution of Stromal Mesenchyme with p53 Loss in Response to Epithelial Tumorigenesis. Cell. 123, 1001-1011.
Faculty Coach: Scott Oakes
|
Collin Melton
"The Elixir of Life: A miRNA that regulates lifespan in C. elegans"
Boehm M, Slack F. A developmental timing microRNA and its target regulate life span in C. elegans.
Science. 2005 Dec 23;310(5756):1954-7.
Faculty Coaches: Allison Xu & Michael McManus |
2/9/06
4pm Journal Club |
|
Don Ganem
"Reconstructing and deconstructing the virus of the 1918 influenza pandemic"
Tumpey et al 2005 Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science 310: 77-80. |
| 2/16/06 |
Mary Mohrin
"Yee-Haw, It's a T Cell Rodeo! Corralling Members of the Immune Synapse".
Mossman KD et al.
Altered TCR signaling from geometrically repatterned mmunological synapses. Science. 2005 Nov 18;310(5751):1191-3.
PMID: 16293763 & Yokosuka Tet al. Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. Nat Immunol. 2005 Dec;6(12):1253-62. Epub 2005 Nov 6.
Faculty Coaches:
Max Krummel & Art Weiss
|
Cathy Collins (student)
"GPI's & Prion Pathogenesis"
Chesebro B. et al.(2005) Anchorless prion protein results in infectious amyloid diesease without clinical scrapie. Science 308: 1435-1439.
Faculty Coaches: Rick Brown & Steven Finkbeiner
|
| 2/23/06 |
Cristina Penaranda
"Playing hide and seek with the immune system"
Smith P et al. Schistosoma mansoni secretes a chemokine binding protein with antiinflammatory activity.
J Exp Med. 2005 Nov 21;202(10):1319-25.
Faculty Coaches: Jason Cyster & Richard Locksley
|
April Price
"Hepatitis C Virus: Running Interference on Interferons"
Li XD et al. Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity PNAS. 2005 December 6. 102(49):17717-22. & Meylan E et al. Cardif is an adaptor protein in the RIG-1 antiviral pathway and is targeted by hepatitis C virus. Nature. 2005 October 20. 437(7062):1167-72.
Faculty coaches: Jeff Cox & Ben Yen |
| 3/2/06 |
Lilliana Radoshevich
"Baby Food: Autophagy in Neonates"
Kuma, A et al.
The role of autophagy during the early neonatal starvation period.
Nature. 2004 Dec 23;432(7020):1032-6. Epub 2004 Nov 3.
Coaches: Jay Debnath & Gerard Evan
|
Paul Sullam (faculty)
"Love in the time of Cholera"
Meibom et al.
Chitin Induces Natural Competence in Vibrio holerae.
Science 310, 1824 - 27, 2005 (December 16, 2005). |
| 3/9/06 |
Nichole Reyes
"Metastasize me: loss of caspase 8 in neuroblastoma promotes metastasis"
Stupack DG et al. Potentiation of neuroblastoma metastasis by loss of caspase-8. Nature. 2006 Jan 5;439(7072):95-9.
Faculty Coaches: Scott Oakes and William Weiss
|
Will Schachterle
"Electric Boogaloo: Double Strand Breakin' and Histone Acetylatin'"
Murr R et al.
Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks.
Nat Cell Biol. 2006 Jan;8(1):91-9.
Coaches: David Toczyski and James Cleaver. |
| 3/16/06 |
Davina Wu
"Yin and yang: finding a balance in appetite regulation"
Zhang JV et al.
Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake.
Science
2005 November
310: 996-999
Faculty Coaches: Christian Vaisse and Allison Xu |
Bob Farese (faculty)
"Caloric restriction and longevity: Can you take NO for an answer?"
Nisoli et al. “Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS”. Science, 2005; 310: 314-7. |
| 3/23/06 |
Lisa Kelly
"Thymi: twice the sweetbreads"
Terszowski, G et al. Evidence for a Functional Second Thymus in Mice Published Online March 2, 2006 Science DOI: 0.1126/science.1123497
Faculty Coaches: Mark Anderson & Nigel Killeen |
Beth Theusch
"Two score minus one base pair spectrin deletion causes "Lincoln disease""
Ikeda, Y. et al. Spectrin mutations cause spinocerebellar ataxia type 5.
Nat Genet. 2006 Jan 22;
Faculty Coaches: Marc Diamond & Louis Ptacek |
| 3/30/06 |
Michelle Toft
"Here I come to save the day: miR-122 enhancement of Hepatitis C Viral RNA accumulation."
Jopling CL et al., Modulation of Hepatitis C Virus RNA Abundance by a Liver-Specific MicroRNA., Science. 2005 Sept. 2;309:1577-1581.
Faculty Coaches: Don Ganem & Michael McManus
|
Andy Leavitt (faculty)
"Nervous Activity and the Flight of the Stem Cell"
Katayama et al. Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow. Cell 2006 124:407-421. |
| 4/6/06 |
Morgan Truitt
"We all get by with a little help from our friends- VEGF induced recruitment of accessory cells promotes neovascularization"
Grunewald et al.
VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell. 2006 Jan 13;124(1):175-89.
Faculty Coaches: Rong Wang, Doug Hanahan |
Angela Sia
"Deep imPAKt: New insight on the cognitive deficits in Alzheimer's disease."
Zhao et al. 2006. Role of p21-activated kinase pathway defects in the cognitive deficits of Alheimer's Disease. Nature Neuroscience, 9(2): 234-42.
Faculty Coaches: Yadong Huang & Paul Muchowski
|
| 4/13/06 |
Nicole Santos
“A sticky issue: Is bigger really better?
Loss of apical junctions increases cerebral cortex size by regulating the Hedgehog pathway.”
Wen-Hui Lien et al. aE-Catenin Controls Cerebral Cortical Size by Regulating the Hedgehog Signaling Pathway. Science Vol311, 1609-1612. 17 March 2006 & supplement
Faculty Coaches: Matthias Hebrok and Eric Huang |
Sue-Ann Lee
"Nuclear Receptor Rev-erba Is a Critical Lithium-Sensitive Component of the Circadian Clock"
Lei Yin, Jing Wang, Peter S. Klein, and Mitchell A. Lazar Science 17 February 2006: 1002-1005.
Faculty Coaches: Ying-Hui Fu and Allan Balmain
|
| 4/20/06 |
Shuyi Zhang
"Live ClariWorm Clear. All day allergy relief."
Wilson MS, et al. 2005. Suppression of allergic airway inflammation by helminth-induced regulatory T cells. Journal of Experimental Medicine. 202(9):1199-1212.
Faculty Coaches: Lewis Lanier and Richard Locksley |
Nga Bien-Ly
"Turning down the BACE: Use of a BACE1 siRNA strategy against Alzheimer's Disease."
Singer et al. Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nat Neurosci. 2005 Oct;8(10):1343-9.
Faculty Coaches: Yadong Huang and Fen-Biao Gao |
| 4/27/06 |
Marine Champsaur
"Cancer stem cells: no need to PreTEN"
Yilmaz OH et al. Pten dependence distinguishes haematopoietic stem cells from
leukaemia-initiating cells. Nature. 2006 Apr 5.
Faculty Coaches: Emmanuelle Passegue and Cliff Lowell
|
Diane Barber (faculty)
"The Force may not be with you"
M. Paszek et al. Tensional homeostasis and the malignant phenotype. 2005 Cancer Cell 8:241. |
| 5/4/06 |
Yun Choi
"The great tragedy of science—"
Faculty Coaches: Diane Barber and Keith Mostov
|
Melissa Ehlers
"Molecularly scarred for life? How changes is chromatin regulation may be keeping you down."
Tsankova etal. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nature Neuroscience 9, 519 - 525 (2006)
Faculty Coaches: Brian Black and Steve Hamilton |
5/11/06
(N-217 this day only) |
Stacyann Forrester
"Breathe a bit easier: Targeting anthrax toxin lethality"
Wei W et al. The LDL Receptor-Related Protein LRP6 Mediates Internalization and Lethality of Anthrax Toxin.
Cell. 2006 Mar 24;124(6):1141-54.
Faculty Coaches: Anita Sil and Merhdad Matloubian |
Bob Nissenson (faculty)
CANCELLED
|
| 5/18/06 |
Julie Gaulden
"Better late than never: MMPs’ role in ischemic stroke recovery"
Zhao et al. "Role of matrix metalloproteinases in delayed cortical responses after stroke" Nature Medicine. 12(4), 441-445 April 2006
Faculty Coaches: Hilary Beggs and Zena Werb |
Wanda Kwan
"A neural paradox: small brain, high IQ?"
P. Shaw et al. Intellectual ability and cortical development in children and adolescents. Nature 440, 676-679 (30 March 2006)
Faculty Coaches: Yadong Huang and Donna Ferriero |
| 5/25/06 |
Jesse Green
"Give the bubble boy some CRAC"
Feske S et al. "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function." Nature. 2006 May 11;441(7090)179-85.
Faculty Coaches: Anthony DeFranco and
Louis Ptacek
|
Holger Willenbring (faculty)
|
| 6/1/06 |
Rachel Jacks
"Food for Thought: The Necessity of Neural Self-Cannibalism"
Hara T et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature. 2006 April 19
Komatsu M et al. Loss of autophagy in the central nervous system causes neurodengeration in mice. Nature. 2006 April 19.
Faculty Coaches: Jay Debnath and Marc Diamond |
Allison Xu (faculty)
"Want to lose weight for good....how about growing more brain cells?"
Kokoeva et al. Neurogenesis in the hypothalamus of adult mice: potential role in energy balance. Science. 2005 Oct 28;310(5748):679-83 |
| 6/8/06 |
Brian Gilliss
"Polycomb repressive complexes: gatekeepers to cellular differentiation."
Polycomb complexes repress developmental regulators in murine embryonic stem cells. LA Boyer et al., Nature. 2006 May 18;441(7091):349-53. Epub 2006 Apr 19.
Faculty Coaches: Tom Kornberg and Miguel Ramalho-Santos |
Bethann Hromatka
"Chronic Hope Through Gene Therapy?"
|
Biomedical Sciences (BMS) Graduate Program