BMS Journal Club:: 2004-05

2004-05 BMS Journal Club
Thursdays, 12:00 Noon
Location: N-217, Parnassus
Videoconferenced to Mission Bay, Room GH S271

Fall Quarter Schedule
Winter Quarter Schedule
Spring Quarter Schedule

9/23/2004 Miles Berger "Partners in crime: Abeta immunotherapy clears tau tangles in a mouse model of Alzheimer's disease." Oddo, S et al, Abeta Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome Neuron, v. 43, pp. 321-332, August 5th 2004 Faculty Coaches: Bruce Miller and Lennart Mucke Don Ganem "Linking chronic inflammatinon to cancer" Greten, Eckmann, Greten, Park, Li, Egan, Kagnoff and Karin (2004) IKK-ß links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118: 285-296
9/30/2004 Vanessa Angeles "No NOBOX, No eggs" Rajkovic A, Pangas SA, Ballow D, Suzumori N, Matzuk MM.NOBOX Deficiency Disrupts Early Folliculogenesis and Oocyte-Specific Gene Expression. Science 2004 Aug 20;305(5687):1157-9. Faculty Coaches: Renee Reijo Pera and Nigel Killeen Corey Largman "What goes on must come off" Cuthbert et al (2004) Histone Deimination antagonizes arginine methylation Cell 118: 545-553
10/7/2004 Steve Chmura "Bugs, Drugs, and the Gut" S. Rakoff-Nahourn, J. Paglino, F. Eslami-Varzaneh, S. Edberg, and R. Medzhitov. Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis. Cell vol 118 pp229-241 July 23, 2004 Faculty Coaches: Averil Ma and David Boone Zena Werb "Cancer Development - a Sticky Subject" White DE, Kurpios NA, Zuo D, Hassell JA, Blaess S, Mueller U, Muller WJ. Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. Cancer Cell. 2004 Aug;6(2):159-70.
10/14/2004 Ben Yen "Adapt or die: Inadequate protection provided by innate immunity against CMV." French AR, Pingel JT, Wagner M, Bubic I, Yang L, Kim S, Koszinowski U, Jonjic S, Yokoyama WM. Escape of mutant double-stranded DNA virus from innate immune control.Immunity. 2004 Jun;20(6):747-56.
10/21/2004 Jesse Lyons "Of Mice and Men: differences in transformation between murine and human cells" Rangarajan A, Hong SJ, Gifford A, Weinberg RA..Species and cell type-specific requirements for cellular transformation.Cancer Cell2004 (6) 171-183 Faculty Coaches: Frank McCormick & Matthias Wabl Nigel Killeen "Of Conditional Benefit" Papp B, Pál C & Hurst LD Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast Nature (2004) 429 :661-4.
10/28/2004 Cory Nicholas "Two of Hearts. . . Two Hearts that Beat as One" Fraidenraich D, Stillwell E, Romero E, Wilkes D, Manova K, Basson CT & Benezra R. Rescue of Cardiac Defects in Id Knockout Embryos by Injection of Embryonic Stem Cells Science 8 October 2004: 247-252 Faculty Coaches: Amy Sehnert & David Gardner Martin McMahon "Something fishy with ribosomal proteins for tumor suppression and translation?" Many Ribosomal Protein Genes Are Cancer Genes in Zebrafish Adam Amsterdam, Kirsten C. Sadler, Kevin Lai, Sarah Farrington, Roderick T. Bronson, Jacqueline A. Lees, Nancy Hopkins. PLoS Biology May 2004 \| Volume 2 \| Issue 5 \| Page 0690
11/4/2004 Zaman Mirzadeh "Keeping an eye on hedgehog" Yamamoto Y, Stock DW, Jeffery, WR. Hedgehog signalling controls eye degeneration in blind cavefish. Nature 14 October 2004: 844-47 Faculty Coaches: Pao-Tien Chuang & Jeremy Reiter Renee Reijo Pera "Reprogramming the genome in the oocyte to embryo transition" Peaston AE, Evsikov AV, Graber JH, de Vries WN, Holbrook AE, Solter D, Knowles B. Retrotransposons regulate host genes in mouse oocytes and reimplantation embryos. Dev Cell. 2004 Oct;7(4):597-606.
11/11/2004	Veteran's Day Holiday
11/18/2004 Suzanne Angeli "Chaperoning Self-Destruction" Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science. 2004 Aug 27;305(5688):1292-5. Faculty Coaches: Marc Diamond, Kaveh Ashrafi Marc Diamond "Aggregates, Shmaggregates: One protein is enough already!" Schaffar G, Breuer P, Boteva R, Behrends C, Tzvetkov N, Strippel N, Sakahira H, Siegers K, Hayer-Hartl M, Hartl FU. Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation. Mol Cell. 2004 Jul 2;15(1):95-105.
11/27/2004	Thanksgiving Holiday
12/2/2004 Vernon Phan "Scrambled or Over Easy" Hochedlinger K, Blelloch R, Brennan C, Yamada Y, Kim M, Chin L, Jaenisch R. Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev. 2004 Aug 1;18(15):1875-85. Faculty Coach: Frank McCormick David Stokoe "Stress, obesity and diabetes: Chill out and eat less dude!" Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GS. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science. 2004 Oct 15;306(5695):457-61.
12/9/2004 Chris Hackett Wang SC, Lien HC, Xia W, Chen IF, Lo HW, Wang Z, Ali-Seyed M, Lee DF, Bartholomeusz G, Ou-Yang F, Giri DK, Hung MC. Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2. Cancer Cell. 2004 Sep;6(3):251-61. Faculty Coaches: Bill Weiss and Graeme Hodgson Joanne Engel "A tale of two of TIRs: you would "ExPECt" them to be similar, why the "EHECK" aren't they?" Campellone KG, Robbins D, Leong JM. EspFU is a translocated EHEC effector that interacts with Tir and N-WASP and promotes Nck-independent actin assembly. Dev Cell. 2004 Aug;7(2):217-28.
12/16/2004	Mimi Zeiger Presentation for First Year Students No Journal Club
12/23/2004	Holiday Break
12/30/2004	Holiday Break
1/6/2005 Won Suk Chung "New link between Wnt and PKA/CREB signaling: Controling of myogenesis". Chen AE, Ginty DD, Fan CM. Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins. Nature. 2004 Nov 28; Faculty Coaches: Didier Stainier & Ben Cheyette Jason Cyster " Natural Killer T cells Prefer Sweet Lipid Heads" Zhou D, Mattner J, …, Teyton L, Bendelac A. (2004) Lysosomal glycosphingolipid recognition by NKT cells. Science 306:1786-9
1/13/2005 Hosein Kouros-Mehr "Cancer stem cells in brain tumors" Singh, S.K., et. al. (2004). Identification of human brain tumour initiating cells. Nature 432, 396 - 401 Faculty Coaches: Zena Werb & Steve Rosen Hal Chapman “What's an epithelial cell anyway?" Houghton J, Stoicov C, Nomura S, Rogers AB, Carlson J, Li H, Cai X, Fox JG, Goldenring JR, Wang TC. Gastric cancer originating from bone marrow-derived cells. Science. 2004 Nov 26;306(5701):1568-71.
1/20/2005 John Morris "Bad things happen when you cross the 'Trk's: TrkB confers resistance to anoikis and actuates metastasis and invasiveness" Douma S, Van Laar T, Zevenhoven J, Meuwissen R, Van Garderen E, Peeper DS. Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. Nature. 2004 Aug 26;430(7003):1034-9. Faculty Coaches: Martin McMahon & David Stokoe Harold Bernstein “Not just any brand of stem cell...” Sherwood, R.I., Christensen, J.L., Conboy, I.M., Conboy, M.J., Rando, T.A., Weissman, I.L., Wagers, A.J. (2004) Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle. Cell 119: 543-54.
1/27/2005 Special 4:00 pm Journal Club Ryan Swenerton "The Shingles Scene: the low-carb lifestyle and spreading herpes". Chen JJ, Zhu Z, Gershon AA, Gershon MD . Mannose 6-phosphate receptor dependence of varicella zoster virus infection in vitro and in the epidermis during varicella and zoster. Cell. 2004 Dec 29;119(7):915-26. Faculty Coaches: Jim McKerrow & Jody Baron Henry Bourne "Supply Lines in the Cell" Rogers SL, Wiedemann U, Hacker U, Turck C, Vale RD. Drosophila RhoGEF2 associates with microtubule plus ends in an EB1- dependent manner. Curr Biol. 2004 Oct 26;14(20):1827-33.
2/3/2005 Pooja Agarwal Mending a broken heart...with Thymosin-beta-4 "Thymosin-beta- 4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair". Ildiko Bock-Marquette, Ankur Saxena, Michael D. White, J. Michael Dimaio & Deepak Srivastava. Nature 432, 466 - 472 Faculty Coaches: Matthias Hebrok & Brian Black
2/10/2005 Special 4:00 pm Journal Club Jessica Van Ziffle "A Lesson in Codependency: Blood Islands in the Fetal Liver" Iavarone A et al. Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages. Nature 23 December 2004. 432(7020): 1040-1045. Faculty Coaches: Brian Black & Cliff Lowell Jeffrey Bluestone "Why You Should Come to UCSF". Kiepiela P et al. Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA. Nature. 2004 Dec 9;432(7018):769-75
2/17/2005 Mary Beth Humphrey (Faculty) "RANK the TRAFfic controller of osteoclastogenesis" Kadono Y, Okada F, Perchonock C, Jang HD, Lee SY, Kim N, Choi Y. Strength of TRAF6 signalling determines osteoclastogenesis. EMBO Rep. 2005 Feb;6(2):171-6. & Gohda J, Akiyama T, Koga T, Takayanagi H, Tanaka S, Inoue JI. RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis. EMBO J. 2005 Jan 27 Tony DeFranco "The riddle of Nod2 and Crohn's disease" Kobayashi KS, Chamaillard M, Ogura Y, Henegariu O, Inohara N, Nunez G, Flavell RA. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science. 2005 Feb 4;307(5710):731-4. & Maeda et al. Nod2 mutation in Crohn's diease potentiates NF-kB activity and IL-1b processing. Science 307: 734, 2005.
2/24/2005 Nathan Hunkapiller "How to Make Your Mouse Testis Pluripotent: Pluripotent Stem Cells from Newborn and Adult Mice." Kanatsu-Shinohara M, Inoue K, Lee J, Yoshimoto M, Ogonuki N, Miki H, Baba S, Kato T, Kazuki Y, Toyokuni S, Toyoshima M, Niwa O, Oshimura M, Heike T, Nakahata T, Ishino F, Ogura A, Shinohara T. Generation of pluripotent stem cells from neonatal mouse testis. Cell. 2004 Dec 29;119(7):1001-12. Faculty coaches: Miguel Ramalho-Santos and Susan Fisher Marina Kolesnichenko (student) "The Ur-Wala of the Cell" Chen IA, Roberts RW, Szostak JW. The emergence of competition between model protocells. Science. 2004 Sep 3;305(5689):1474-6. Faculty Coaches: Alan Frankel & Matthias Wabl
3/3/2005 Jaime Lopez "The Good, The Bad and The Ugly Stomach Fat" Fukuhara A, et al. Visfatin: A Protein Secreted by Visceral Fat that Mimics the Effects of Insulin. Science. (2005) Vol 307, 426-430. Faculty Coaches: Mike German & Christian Vaisse H. Jeffrey Lawrence "Pokemon - not just a kid's game any more" Maeda T, Hobbs RM, Merghoub, T, Guernah I, Zelent A, Cardon-Cardo C, Teruya-Feldstein J, Pandolfi PP. Role of the proto-oncogene Pokemon in cellular transformation and ARF repression. Nature 433:278 (Jan 20, 2005)
3/10/2005 Landys Lopez-Quezada "A Rose by Any Other Function . . . " Koropatnick TA, Engle JT, Apicella MA, Stabb EV, Goldman WE, McFall-Ngai MJ. Microbial Factor-Mediated Development in a Host-Bacterial Mutualism SCIENCE 306: 1186-1188. Faculty Coaches: Anita Sil & Richard Locksley Theodora Mauro "Stressed out- ATP2C1 in Keratinocytes" Ramos-Castaneda J, Park YN, Liu M, Hauser K, Rudolph H, Shull GE, Jonkman MF, Mori K, Ikeda S, Ogawa H, Arvan P. Deficiency of ATP2C1, a golgi ion pump, induces secretory pathway defects in ER-associated degradation and sensitivity to ER-stress. J Biol Chem. 2004 Dec 28
3/17/2005 Elizabeth Mack "Human Embryonic Stem Cells: Sugar and Spice and Everything Not So Nice" Martin MJ, Muotri A, Gage F, Varki A. Human embryonic stem cells express an immunogenic nonhuman sialic acid. Nat Med. 2005 Feb;11(2):228-32. Faculty Coaches: Susan Fisher & Renee Reijo Pera Jennifer LaVail "Forever Tango: The Intimate Dance of the Host Neuron and Virus" Feuer, R., Pagarigan, R.R. Harkins, S, Liu, F, Hunziker, I.P. and J.L. Whitton. Coxsackievirus targets proliferating neuronal progenitor cells in the neonatal CNS. J. Neurosci. 25 (9): 2434-2444, 2005.
3/24/2005 Patrick Murphy "The little things that kill" McKay BC, Stubbert LJ, Fowler CC, Smith JM, Cardamore RA, Spronck JC.Regulation of ultraviolet light-induced gene expression by gene size.Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6582-6 Faculty Coaches: James Cleaver & John Fike Dorit Ron "New function for an old enzyme - tPA and alcohol-withdrawal" Pawlak R, Melchor JP, Matys T, Skrzypiec AE, Strickland S. Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors. Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):443-8.
3/31/2005 Angell Shieh "A Role for RalGDS in Oncogenesis" Ana González-García, Catrin A. Pritchard, Hugh F. Paterson, Georgia Mavria, Gordon Stamp, and Christopher J. Marshall1. (March 2005). RalGDS is required for tumor formation in a model of skin carcinogenesis. Cancer Cell, Vol 7, 219-226. Faculty Coach: Kevin Shannon Elizabeth Szyleyko (student) "It takes all the running you can do, just to keep in the same place" Pfeffer S., Zavolan M., Grasser F.A., Chien M., Russo J.J., Ju J., John B., Enright A.J., Marks D., Sander C., and Tuschl T. Identification of Virus-Encoded MicroRNAs. Science (2004) 04:734-736. Faculty Coach: Michael McManus & Raul Andino
4/7/2005 Brigitte Watkins " Macrophage vs Dendritic Cell: The Race of Antigen Degradation" Delamarre L, Pack M, Chang H, Mellman I, Trombetta ES. Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate. Science. 2005 Mar 11;307(5715):1630-4. Faculty Coach: Hal Chapman & Jeffrey Cox Steven Hamilton "The impact of a large polymorphic inversion in the human genome" Stefansson H, et al. A common inversion under selection in Europeans Nat Genet. 2005 Feb;37(2):129-37. & Supplementary Figures
4/14/2005 Amy Young "Izumo: Clearing up the confusion over sperm and egg fusion" Inoue, N., Ikawa, M., Isotani, A, Okabe, M. The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. Nature. 2005 Mar 10; 434(7030):234-8. Faculty Coaches: Susan Fisher & Renee Reijo Pera
4/21/2005 Courtney Brown "My heart will go on...because of isl1+ cardioblasts" Laugwitz KL, Moretti A, Lam J, Gruber P, Chen Y, Woodard S, Lin LZ, Cai CL, Lu MM, Reth M, Platoshyn O, Yuan JX, Evans S, Chien KR. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 2005 Feb 10;433(7026):647-53. Faculty Coaches: Harold Bernstein & Rong Wang Larry Shiow (student) "Shisa: A Lesson in Getting a Head" Yamamoto A, Nagano T, Takehara S, Hibi M, Aizawa S. "Shisa promotes head formation through inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF" Cell 2005 Jan 28; 120 (2): 223-35 Faculty Coaches: Gail Martin & Ben Cheyette
4/28/2005 Trinna Cuellar “Lethal Weapon 7: Keeping those Bad RASses at Bay". Johnson SM., Grosshans H., Shingara J., Byrom M., Jarvis R., Cheng A., Labourier E., Reinert K.L., Brown, D., Slack F.J. (2005) RAS is Regulated by the let-7 MicroRNA Family. Cell 120:635-647. Faculty Coaches: David Stokoe & Rong Wang Michael McManus "MicroRNAs on the Brain" Giraldez AJ, Cinalli RM, Glasner ME, Enright AJ, Thomson MJ, Baskerville S, Hammond SM, Bartel DP, Schier AF. MicroRNAs Regulate Brain Morphogenesis in Zebrafish. Science. 2005 Mar 18
5/5/2005 Rebecca Doctors "Nothing to Sneeze About" Zhu D, Kepley CL, Zhang K, Terada T, Yamada T, Saxon A. A chimeric human-cat fusion protein blocks cat-induced allergy. Nat Med. 2005 Apr;11(4):446-9 Faculty Coaches: Nigel Killeen & Mehrdad Matloubian Erik Ullian "Noisy neurons find their way." Hanson MG, Landmesser LT. Normal patterns of spontaneous activity are required for correct motor axon guidance and the expression of specific guidance molecules. Neuron. 2004 Sep 2;43(5):687-701.Ullian
5/12/2005 Bess Frost "Vintage genes upset Mendel " Lolle SJ, Victor JL, Young JM, Pruitt RE. Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsis. Nature. 2005 Mar 24;434(7032):505-9. Faculty Coaches: Nigel Killeen & Michael Mcmanus Daniel Garcia (student) "Keep that spark alive: Viagra for aged stem cells" Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature. 2005 Feb 17;433(7027):760-4. Faculty Coaches: Montgomery Bissell and Andrew Leavitt
5/19/2005 Julia Gilden "Gap Junction, What's Your Function?" Neijssen J, Herberts C, Drijfhout JW, Reits E, Janssen L, Neefjes J. Cross-presentation by intercellular peptide transfer through gap junctions. Nature. 2005 Mar 3;434(7029):83-8. Faculty Coaches: Jody Baron & Larry Fong Eric Huang "The Iliad, Part II: What Homer forgot to mention about Troy and Neural regeneration". Park, J.B., et al. A TNF receptor family member, Troy, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. Neuron 45: 345-351, 2005. & Shao, Z., et al. TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration. Neuron 45: 353-359, 2005.
5/26/2005 Kelly Haston "Imprinted to be female: The story of a few strong XX germ cells that dared to be eggs in a male dominated environment" Isotani A, Nakanishi T, Kobayashi S, Lee J, Chuma S, Nakatsuji N, Ishino F, Okabe M. Genomic imprinting of XX spermatogonia and XX oocytes recovered from XX-XY chimeric testes PNAS 2005 102: 4039-4044 Coaches: Renee Reijo Pera & Joe Costello Ed Goetzl "The PYRIN connection to Periodic Fever Syndromes" McDermott, M.F. 2004 A common pathway in periodic fever syndromes. TRENDS in Immunology 25: 457-460. & Kinoshita, T., et al., PYPAF3, a PYRIN-containing APAF-1-like protein, is a feed-back regulator of caspase-1-dependent interleukin -1beta secretion. J. Biol. Chem. (Ms. in press, April 06, 2005).