Biomedical Sciences Graduate Program | University of California, San Francisco

Arthur Weiss, MD, PhD

Signal Transduction Events and Lymphocyte Activation

Selected Publications

phone	(415) 476-8983
email	aweiss@medicine.ucsf.edu
additional websites	Tetrad Graduate Program Immunology Graduate Program Howard Hughes Medical Institute
secondary research affiliation	Cancer Biology & Cell Signaling

The response of T lymphocytes to antigen presents a unique opportunity to study how complex molecular interactions between cells can lead to cell differentiation and proliferation. We are interested in understanding how T and B cell receptors involved in antigen recognition initiate signal transduction events that regulate cell responses. We know that such receptors functionally interact with tyrosine kinases and phosphatases, enzymes that regulate protein phosphorylation, to induce signaling pathways that regulate gene expression. By studying the mechanisms by which these molecules are regulated and how they control cellular responses in development, we hope to understand how signaling pathways in normal immune responses and how perturbations in these pathways can lead to immune deficiency or autoimmunity.

Selected Publications

Phee, H., R. T. Abraham, and A. Weiss. Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1. Nat Immunol 6 :608-617 , 2005.

Brdicka, T., T. A. Kadlecek, J. P. Roose, A. W. Pastuszak, and A. Weiss. Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases. Mol Cell Biol 25 :4924-4933 , 2005.

Hermiston, M. L., A. L. Tan, V. A. Gupta, R. Majeti, and A. Weiss. The juxtamembrane wedge negatively regulates CD45 function in B cells. Immunity 23 :635-647 , 2005.

Myers, M. D., T. Sosinowski, L. L. Dragone, C. White, H. Band, H. Gu, and A. Weiss. Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex. Nat Immunol 7: 57-66 , 2006.

Roose, J., M. Mollenauer, M. Ho, T. Kurosaki, and A. Weiss. Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. Mol Cell Biol 27 :2732-2745, 2007.

Deindl, S., T. A. Kadlecek, T. Brdicka, X. Cao, A. Weiss, and J. Kuriyan. Structural basis for the inhibition of tyrosine kinase activity of ZAP-70. Cell 129 :735-746 , 2007.

Zhu, J.W.*, T. Brdicka*, T.R. Katsumoto, J. Lin, and A. Weiss. Structurally distinct phosphatases CD45 and CD148 regulate B cell and macrophage immunoreceptor signaling. Immunity 28 :183-196, 2008.
* co-first authors

Levin, S.E., C. Zhang, T.A. Kadlecek, K. Shokat, and A. Weiss, A. Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling. J Biol Chem 283 :15419-15430, 2008.

information last updated June 2008