Saptarsi Haldar, MD, BS

Associate Investigator, Gladstone Institutes
Associate Professor of Medicine
Cardiovascular Division
+1 415 734-4058

Clinical: I am a cardiologist specializing in general adult cardiology.

Research: I am a principal investigator at the Gladstone Institute of Cardiovascular Disease and the University of California, San Francisco. My scientific focus is to understand gene-regulatory and epigenetic mechanisms governing cell state transitions in the cardiovascular system and in skeletal muscle with an ultimate goal of finding novel therapeutic strategies to prevent and treat heart failure, cardiometabolic, and myopathic diseases.

A major focus of our team is in the pathobiology of heart failure, a devastating disease for which morbidity and mortality remain extremely high despite current standards of medical care. As a practicing physician-scientist that recognizes this major unmet need, one of my laboratory’s central goals is to discover novel mechanisms underlying heart failure pathogenesis and to develop new therapeutic strategies for this extremely common and lethal condition. We have a deep interest in the very nascent area of cardiovascular epigenetics and seek to unravel how chromatin-dependent signal transduction drives cardiovascular plasticity during physiological and pathophysiological states. As epigenetic regulators and chromatin-associated proteins are often tractable drug targets, we actively seek to translate our findings into novel transcriptionally-active cardiovascular therapeutics.

Primary Thematic Area: 
Vascular & Cardiac Biology
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Gene Regulation and Epigenetics in Cardiovascular and Metabolic Physiology/Disease

Websites

Publications: 

Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice.

Cell metabolism

Newman JC, Covarrubias AJ, Zhao M, Yu X, Gut P, Ng CP, Huang Y, Haldar S, Verdin E

BRD4 inhibition for the treatment of pathological organ fibrosis.

F1000Research

Stratton MS, Haldar SM, McKinsey TA

BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure.

Science translational medicine

Duan Q, McMahon S, Anand P, Shah H, Thomas S, Salunga HT, Huang Y, Zhang R, Sahadevan A, Lemieux ME, Brown JD, Srivastava D, Bradner JE, McKinsey TA, Haldar SM

Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA.

Cell reports

Stratton MS, Lin CY, Anand P, Tatman PD, Ferguson BS, Wickers ST, Ambardekar AV, Sucharov CC, Bradner JE, Haldar SM, McKinsey TA

Sarcomeres and Cardiac Growth: Tension in the Relationship.

Trends in molecular medicine

Haldar SM, Srivastava D