Biomedical Sciences Graduate Program | University of California, San Francisco

Joseph McCune, MD, PhD
Pathogenic Mechanisms, Treatment, and Prevention of HIV Disease

Selected Publications | Complete Publications

phone	(415) 206-8101
email	mike.mccune@ucsf.edu
additional websites	Cancer Center Immunology Graduate Program
secondary research affiliation	Immunology

The work in this laboratory focuses on the definition of pathogenic mechanisms of viral diseases, particularly HIV-1 disease. This focus has spanned a range of fields, from understanding critical structural determinants of infectivity (McCune et al., Cell 1988), to devising a small animal model (the SCID-hu Thy/Liv mouse) to study HIV pathogenesis and to prioritize antiretroviral compounds against HIV (McCune et al., Science 1988a, 1988b, 1990), to studying mechanisms of T cell depletion and repletion in vivo (Bonyhadi et al., Nature 1993; Su et al., Immunity 1995; Komanduri et al., Nature Medicine 1998; Hellerstein et al., Nature Medicine 1998; Stoddart et al., Nature Medicine 2001; McCune Nature 2001). This body of work has involved hypothesis-driven, patient-oriented research engaging collaborative teams of basic scientists, translational researchers, and clinicians. Most recently, attention has been devoted to understanding the correlates of protective immunity against HIV, with the specific intent to work with others to develop an effective vaccine. This change has been materialized by the creation of the Division of Experimental Medicine, in which multiple investigators working on the human immunology of chronic infectious diseases (e.g., HIV, TB, malaria, etc) will be working together.

Selected Publications

Hartigan-O’Connor D, Poon CK, Sinclair E, McCune JM. Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. J. Immunol. Methods 30:41-52, 2007.

Miller CJ, Genesca M, Abel K, Montefiore D, Forthal D, Bost K, Li J, Favre D, McCune JM. Antiviral antibodies are necessary for control of SIV replication. J. Virol. 81:5024-35, 2007.

Kanwar B, Gao D-G, Pan M-H, Hwang A, Feng J, Grenert JP, Williams S, Franc B, McCune JM. In vivo imaging of mucosal CD4+ T cells using single photon emission computed tomography in a murine model of colitis. J. Immunol. Methods 329:21-30, 2008.

Napolitano LA, Schdmit D, Gotway MB, Ameli N, Filbert EL, Ng MM, Clor JL, Epling L, Sinclair E, Baum PD, Li K, Killian ML, Bacchetti P, McCune JM. Growth hormone enhances thymic function in HIV-infected adults. J. Clin. Invest. 118:1085-98, 2008.

Schweneker M, Favre D, Martin JN, Deeks SG, McCune JM. HIV-induced changes in T cell signaling pathways. J. Immunol. 180:6490-6502, 2008.

Ladell K, Hellerstein M, Cesar D, Busch R, Boban D, McCune JM. Central memory CD8+ T cells have a shorter lifespan and reduced abundance as a function of HIV disease progression. J. Immunol. 180:7907-7918, 2008.

Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan M, McCune JM, Ahuja SK. Apolipoprotein E influences HIV-1 cell entry and disease progression, Proc. Natl. Acad. Sci., USA, 105:8718-8723, 2008.

Mold JE, Michaelsson J, Burt TD, Muench MO, Beckerman KP, Busch MP, Lee T-H, Nixon DF, and McCune JM. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science, 322:1562-65, 2008.

Favre D, Lederer S,* Kanwar B,* Min Ma Z,* Proll S, Kasakow Z, Mold J, Swainson L, Barbour JD, Baskin CR, Palermo R, Pandrea I, Miller C, Katze M, McCune JM. Critical loss of the balance between TH17 and T regulatory cell populations in pathogenic SIV infection. PLoS Pathogens, e1000295, Epub Feb 13 2009. (*co-equal authors)

Lederer S,* Favre D,* Walters K-A, Proll S, Kanwar B, Kasakow Z, Baskin CR, Palermo R, McCune JM, Katze MG. Transcriptional profiling reveals significant distinctions in kinetics and tissue compartmentalization between pathogenic and non-pathogenic SIV infection, PLoS Pathogens, e1000296, Epub Feb 13 2009. (*co-equal authors)

information last updated May 2009