Max Krummel, PhD

Professor
Department of Pathology
+1 415 514-3130

Our work focusses on understanding patterns of immune cell-cell interactions and how these generate “the immune system”. Our studies of the immune synapse have shown how T cells regulate their motility, how they signal through synapses while moving, how they communicate with each other during arrest, and how they ‘search’ a new tissue. These are all fundamental findings and provide a lens through which we understand T cell function.

Over the past four years, we have developed novel methods and computational platforms to understand immunological processes in space and in time within normal and diseased organs. We were the first to live-image events in progressive tumors in which incoming tumor-specific T cells are captured by a population of myeloid cells. I am tremendously excited that we have begun to develop a pipeline of next-generation protein immuno-therapeutics using imaging to ‘guide’ this development.

Concurrently, we co-developed a  imaging technologies that allow, for the first time, observation of the immune system in the homeostatic, infected/injured, allergic or metastatic lung. As with primary tumors, this latter focus has allowed us to dismiss many hypothetical immune scenarios and intensely study those that define the biology in situ. 

These studies define how the immune system is organizing over space and time and guides novel therapeutic solutions.

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Cancer Biology & Cell Signaling
Research Summary: 
The Immune Response in 4 Dimensions

Websites

Publications: 

Visualization of immediate immune responses to pioneer metastatic cells in the lung.

Nature

Headley MB, Bins A, Nip A, Roberts EW, Looney MR, Gerard A, Krummel MF

T cell migration, search strategies and mechanisms.

Nature reviews. Immunology

Krummel MF, Bartumeus F, Gérard A

Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity.

Cancer cell

Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF

Detection of rare antigen-presenting cells through T cell-intrinsic meandering motility, mediated by Myo1g.

Cell

Gérard A, Patino-Lopez G, Beemiller P, Nambiar R, Ben-Aissa K, Liu Y, Totah FJ, Tyska MJ, Shaw S, Krummel MF

Modes and mechanisms of T cell motility: roles for confinement and Myosin-IIA.

Current opinion in cell biology

Krummel MF, Friedman RS, Jacobelli J