Kayarat Nair, PhD

Assistant Professor
Department of Ophthalmology
NairS@vision.ucsf.edu

Sai Nair, PhD is an Assistant Professor of Ophthalmology and Anatomy. He obtained a PhD in Biochemistry from the University of Mumbai, India. During his PhD, Dr. Nair studied the role of cell surface receptors in regulation of neutrophil effector functions. Dr. Nair received his postdoctoral training in Dr. Simon John’s laboratory at The Jackson Laboratory. He worked extensively on characterizing both spontaneous and chemically induced mouse mutants that recapitulate features of human glaucoma. He has identified genes contributing to glaucoma, generated new mouse models of human glaucoma and have utilized them to gain insight into the underlying pathological causes of the disease. In 2013, he joined the UCSF faculty where his lab studies the role of genetic factors contributing to ocular diseases with a major focus on glaucoma. His laboratory employs a multi-disciplinary approach by integrating the use of animal models, genetics, genomics, molecular biology, cell-biology and physiology based experiments to gain mechanistic insight into disease pathogenesis.

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Neurobiology
Research Summary: 
Genetics and biology of ocular diseases

Websites

Publications: 

YBR/EiJ mice: a new model of glaucoma caused by genes on chromosomes 4 and 17.

Disease models & mechanisms

Nair KS, Cosma M, Raghupathy N, Sellarole MA, Tolman NG, de Vries W, Smith RS, John SW

Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities.

Experimental eye research

Fernandes KA, Harder JM, Williams PA, Rausch RL, Kiernan AE, Nair KS, Anderson MG, John SW, Howell GR, Libby RT

ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma.

PLoS genetics

Nongpiur ME, Khor CC, Jia H, Cornes BK, Chen LJ, Qiao C, Nair KS, Cheng CY, Xu L, George R, Tan D, Abu-Amero K, Perera SA, Ozaki M, Mizoguchi T, Kurimoto Y, Low S, Tajudin LS, Ho CL, Tham CC, Soto I, Chew PT, Wong HT, Shantha B, Kuroda M, Osman EA, Tang G, Fan S, Meng H, Wang H, Feng B, Yong VH, Ting SM, Li Y, Wang YX, Li Z, Lavanya R, Wu RY, Zheng YF, Su DH, Loon SC, Yong VK, Allingham RR, Hauser MA, Soumittra N, Ramprasad VL, Waseem N, Yaakub A, Chia KS, Kumaramanickavel G, Wong TT, How AC, Chau TN, Simmons CP, Bei JX, Zeng YX, Bhattacharya SS, Zhang M, Tan DT, Teo YY, Al-Obeidan SA, Hon do N, Tai ES, Saw SM, Foster PJ, Vijaya L, Jonas JB, Wong TY, John SW, Pang CP, Vithana EN, Wang N, Aung T

Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice.

Nature genetics

Nair KS, Hmani-Aifa M, Ali Z, Kearney AL, Ben Salem S, Macalinao DG, Cosma IM, Bouassida W, Hakim B, Benzina Z, Soto I, Söderkvist P, Howell GR, Smith RS, Ayadi H, John SW