Jonah Chan, PhD

Professor
Department of Neurology
+1 415 514-9818

Dr. Jonah R. Chan received his BS in Biochemistry and PhD in Neuroscience at the University of Illinois at Urbana-Champaign. He completed a postdoctoral fellowship in the Department of Neurobiology at Stanford University with Dr. Eric Shooter. Jonah is currently the Debbie and Andy Rachleff Distinguished Professor of Neurology. He is a member of the Neuroscience Graduate Program and the MS Research Center at UCSF.

The Chan laboratory has a long-standing interest in fundamental glial/neuronal interactions and the molecular mechanisms that regulate myelination. Myelination is one of the most exquisite examples of cell-cell interaction found in nature and functions to maximize the efficiency and velocity of action potentials transmitted throughout the nervous system. While much has been learned about the global determinants that generate myelin-forming cells during development, the Chan laboratory is particularly interested in understanding how local environmental cues control the spatiotemporal regulation of differentiation and myelination, including both molecular and biophysical interactions. Identification of an environment that is conducive for myelination could have important implications for efforts aimed at promoting repair and remyelination in the nervous system.

Current Laboratory Members:

Trung Huynh, BS
Lab Manager
Trung.Huynh@ucsf.edu

Sonia Mayoral, PhD
Postdoctoral Fellow
sonia.mayoral@ucsf.edu

Kae-Jiun Chang, PhD
Postdoctoral Fellow
kae-jiun.chang@ucsf.edu

Lindsay Osso, BS
Graduate Student
lindsay.osso@ucsf.edu

Simon Pan, BS
MSTP Graduate Student
simon.pan.808@gmail.com

Kelsey Rankin, BS
Assistant Specialist
kelseyrankin11@gmail.com

Sarah Raissi, PhD
Postdoctoral Fellow
sarah.raissi@ucsf.edu

Primary Thematic Area: 
Neurobiology
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Neuronal/Glial Interactions that Control Myelination

Websites

Publications: 

Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial.

Lancet (London, England)

Green AJ, Gelfand JM, Cree BA, Bevan C, Boscardin WJ, Mei F, Inman J, Arnow S, Devereux M, Abounasr A, Nobuta H, Zhu A, Friessen M, Gerona R, von Büdingen HC, Henry RG, Hauser SL, Chan JR

Mechanical plasticity during oligodendrocyte differentiation and myelination.

Glia

Domingues HS, Cruz A, Chan JR, Relvas JB, Rubinstein B, Pinto IM

Architecting the myelin landscape.

Current opinion in neurobiology

Osso LA, Chan JR

Regulatory T cells promote myelin regeneration in the central nervous system.

Nature neuroscience

Dombrowski Y, O'Hagan T, Dittmer M, Penalva R, Mayoral SR, Bankhead P, Fleville S, Eleftheriadis G, Zhao C, Naughton M, Hassan R, Moffat J, Falconer J, Boyd A, Hamilton P, Allen IV, Kissenpfennig A, Moynagh PN, Evergren E, Perbal B, Williams AC, Ingram RJ, Chan JR, Franklin RJ, Fitzgerald DC

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery.

eLife

Mei F, Lehmann-Horn K, Shen YA, Rankin KA, Stebbins KJ, Lorrain DS, Pekarek K, A Sagan S, Xiao L, Teuscher C, von Büdingen HC, Wess J, Lawrence JJ, Green AJ, Fancy SP, Zamvil SS, Chan JR