Jeroen Roose

Professor
Department of Anatomy
+1 415 476-3977
Research Overview: 

The Roose lab focuses on understanding cell fate decisions driven by cell-cell interactions and signaling pathways, in the context of cancer, autoimmune diseases, and COVID-19. Our collaborative research programs benefit from many technology platforms, such as organoids, CyTOF, single cell RNAseq, spectral flow, mouse models, and patient samples. Dr. Roose is a co-founder of the Bakar ImmunoX initiative at UCSF and a co-lead investigator on the UCSF Endeavor Program that focuses on cancer metastasis, funded through the Mark Foundation for Cancer Research.

Most recently, we have identified rules of epithelial-immune cell crosstalk in metastatic cancer (Gonzalez, Cell 2022. PMID35063085), we have developed organoids co-cultured with immune cells (unpublished work), and we are testing hypotheses of the crosstalk in organoids, informed by large omics datasets.

Couple of words about myself; I trained with Profs. Hans Clevers and Art Weiss, obtaining cancer- and immune- expertise. I started my own group at UCSF in 2007, I am now full Professor and also Vice Chair of my Anatomy Department at UCSF.

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Immunology
Research Summary: 
My lab focuses on understanding cell fate decisions driven by cell-cell interactions and signaling pathways, in the context of immunology, cancer, and stem cell biology.

Websites

Publications: 

Abstract A046: nSMase2-generated ceramide promotes PDA aggression through exosome reprogramming of the stroma.

Cancer research

Audrey M. Hendley, Atsushi Urano, Xianlu L. Peng, Sudipta Ashe, Tuan A. Phu, Martin Ng, Natanya R. Kerper, David I. Berrios, Jonghyun Lee, David Jin, Gun H. Jang, Oghenekevwe M. Gbenedio, Jeroen P. Roose, Jen J. Yeh, Steven Gallinger, Andrew V. Biankin, Vasilis Ntranos, David K. Chang, David W. Dawson, Grace E. Kim, Valerie M. Weaver, Robert L. Raffai, Matthias Hebrok

Single cell proteomics characterization of bone marrow hematopoiesis with distinct Ras pathway lesions.

bioRxiv : the preprint server for biology

Karra L, Finger AM, Shechtman L, Krush M, Huang RM, Prinz M, Tennvooren I, Bahl K, Hysienaj L, Gonzalez PG, Combes AJ, Gonzalez H, Argüello RJ, Spitzer MH, Roose JP

Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression.

Cancer cell

Jana S, Brahma S, Arora S, Wladyka CL, Hoang P, Blinka S, Hough R, Horn JL, Liu Y, Wang LJ, Depeille P, Smith E, Montgomery RB, Lee JK, Haffner MC, Vakar-Lopez F, Grivas P, Wright JL, Lam HM, Black PC, Roose JP, Ryazanov AG, Subramaniam AR, Henikoff S, Hsieh AC

SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.

Stem cell reports

Hysenaj L, Little S, Kulhanek K, Magnen M, Bahl K, Gbenedio OM, Prinz M, Rodriguez L, Andersen C, Rao AA, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Mick E, Khalid MM, Taha TY, Kumar R, Li JZ, Ding VW, Matsumoto S, Maishan M, Sreekumar B, Simoneau C, Nazarenko I, Tomlinson MG, Khan K, von Gottberg A, Sigal A, Looney MR, Fragiadakis GK, Jablons DM, Langelier CR, Matthay M, Krummel M, Erle DJ, Combes AJ, Sil A, Ott M, Kratz JR, Roose JP