Jeroen Roose

Associate Professor
Department of Anatomy
+1 415 476-3977

Research Interests:

Our laboratory is interested in genetic lesions that lead to abnormal Ras signal transduction events and development of diseases such as autoimmunity and cancer. Active Ras communicates to many downstream targets and affects many cell biological responses. Our goal is to understand the mechanism of activation of the small GTPase Ras by Ras exchange factors and its role in normal physiology as well as understand how alterations in Ras-kinase signals underlie pathology.

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
None
Research Summary: 
Our goal is to understand how different flavors of receptor triggered Ras signals drive normal developmental processes of various cell types and organ systems and how (and why) perturbations of Ras-kinase signals cause human disease

Websites

Publications: 

Tonic Signals: Why Do Lymphocytes Bother?

Trends in immunology

Myers DR, Zikherman J, Roose JP

Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.

Cell reports

Myers DR, Lau T, Markegard E, Lim HW, Kasler H, Zhu M, Barczak A, Huizar JP, Zikherman J, Erle DJ, Zhang W, Verdin E, Roose JP

RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma.

Cancer cell

Chen X, Wu Q, Depeille P, Chen P, Thornton S, Kalirai H, Coupland SE, Roose JP, Bastian BC

One-way membrane trafficking of SOS in receptor-triggered Ras activation.

Nature structural & molecular biology

Christensen SM, Tu HL, Jun JE, Alvarez S, Triplet MG, Iwig JS, Yadav KK, Bar-Sagi D, Roose JP, Groves JT