Warner Greene, MD, PhD
Molecular Analysis of HIV Pathogenesis

Selected Publications | Complete Publications

phone	(415) 734-4805
email	wgreene@gladstone.ucsf.edu
additional websites	Gladstone Institute of Virology & Immunology Lab website AIDS Research Institute
secondary research affiliation	Immunology

My laboratory focuses on the pathogenic interplay of the HIV-1 and HTLV-I human retroviruses with immune cells. Infection of human hosts with these retroviruses produces contrasting diseases within the CD4 subset of T lymphocytes, specifically the Acquired Immune Deficiency Syndrome (AIDS) with HIV-1 and the Adult T-cell Leukemia (ATL) with HTLV-1. Their studies explore the molecular biology of the HIV Vif, Nef and Vpr gene products as well as the transforming properties of HTLV-I Tax. More recently, we have begun to study HIV and HTLV-1 Env-mediated fusion and the mechanisms underlying transmission of HIV across the female genital mucosa.

We continue to also pursue our longstanding interest in the biology of the NF-kB/Rel family of transcription factors, which serve as "master regulators" of the immune and inflammatory responses. These studies currently focus on the role of these transcription factors as major antagonists of HIV latency. .

Selected Publications

Geleziunas R, Xu W, Takeda K, Ichijo H, Greene WC. HIV-1 Nef inhibits ASK1-dependent death signaling providing a potential mechanism for protecting the infected host cell. Nature 410:834-838, 2001.

de Noronha CMC, Sherman MP, Lin HW, Cavrois MV, Moir RD, Goldman RD, Greene WC. Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr. Science 294:1105-1108, 2001.

Chen LF, Fischle W, Verdin E, Greene WC. Duration of nuclear NF-kB action is regulated by reversible acetylation. Science 293:1653-1657, 2001.

Greene WC, Peterlin BM. Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy. Nat. Med. 8:673-680, 2002.

Chen LF, Mu Y, Greene WC. Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kB. EMBO J. 21:6539-6548, 2002.

Stopak K, de Noronha C, Yonemoto W, Greene WC. HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability. Mol. Cell 12:591-601, 2003.

Greene WC. The brightening future of HIV therapeutics. Nat. Immunol. 5:867-871, 2004.

Chiu Y-L, Soros VB, Kreisberg JF, Stopak K, Yonemoto W, Greene WC. Cellular APOBEC3G restricts HIV-1 infection in resting CD4 T cells. Nature 435:108-114, 2005.

Williams SA, Chen LF, Kwon H, Ruiz-Jarabo CM, Verdin E, Greene WC. NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. EMBO J. 25:139-49, 2006

Cavrois M, Neidleman J, Kreisberg JF, Greene WC. In Vitro Derived Dendritic Cells Trans -infect CD4 T Cells Primarily with Surface-bound HIV-1 Virions. PLoS Path. 3:e4, 2007.

Soros VB, Yonemoto W, Greene WC. Newly synthesized APOBEC3G is incorporated into HIV virions, inhibited by HIV RNA, and subsequently activated by RNase H. PLoS Path. e:315, 2007

Greene WC. A history of AIDS: Looking back to see ahead. Eur. J. Immunol. 37:S94–102, 2007.Williams SA, Kwon H, Chen L-F, Greene WC. Sustained induction of NF-kB is required for efficient expression of latent HIV-1. J. Virol. 81:6043–6056, 2007.

Chiu YL, Greene WC. The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements. Annu Rev Immunol. 26:317-353, 2008.

Cavrois M, Neidleman J, Greene WC. The Achilles heel of the Trojan horse model of HIV trans-infection. PLoS Path. 4:e1000051, 2008. PMCID: PMC2430767

Santiago ML, Montano M, Benitez R, Messer RJ, Yonemoto W, Chesebro B, Hasenkrug KJ, Greene WC. APOBEC3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection. Science 321:1343–1346, 2008.

Richman DD, Margolis DM, Delaney M, Greene WC, Hazuda D, Pomerantz RJ. The challenge of finding a cure for HIV infection. Science323:1304–1307, 2009.

Information last updated June 2009