Evan Feinberg, PhD

Assistant Professor
Department of Anatomy
+1 415 502-3619

My lab aims to understand how sensory input is represented in the brain and transformed into behavioral commands. We study this problem in the superior colliculus (SC), a structure comprising functionally diverse sensory and motor neurons interleaved with fibers from myriad cortical and subcortical areas. This remarkable neuroanatomy poises the SC as an integrative hub, but has also hindered efforts to dissect SC circuitry using classical methods, such as lesions, that offer poor spatial and temporal resolution. In order to record from and manipulate genetically defined cell types, we study the mouse SC, where we capitalize on an experimental preparation I developed that allows two-photon imaging of neuronal population activity in the SC of awake animals. We apply these methods to decipher computations in the context of quantitative behavioral assays. Our long-term goal is to understand how the brain encodes information from input to output.

Primary Thematic Area: 
Neurobiology
Secondary Thematic Area: 
None
Research Summary: 
Cortical-subcortical networks for sensory processing and behavior

Websites

Featured Publications: 

GFP Reconstitution Across Synaptic Partners (GRASP) defines cell contacts and synapses in living nervous systems.

Neuron

Feinberg EH, Vanhoven MK, Bendesky A, Wang G, Fetter RD, Shen K, Bargmann CI

Transport of dsRNA into cells by the transmembrane protein SID-1.

Science (New York, N.Y.)

Feinberg EH, Hunter CP