Erin Gordon, MD

Assistant Professor
Medicine
+1 415 476-0752

I am a physician-scientist with an interest in airway epithelial dysfunction in asthma. Specifically, my lab focuses on understanding how genetic risk variants that are associated with asthma at a population level, actually confer risk of disease at a molecular level. We use novel techniques such as conditionally reprogrammed primary airway epithelial cells, CRISPR gene deletion, and biospecimens from large numbers of human subjects to discover the function of genes associated with asthma and elucidate the causal single nucleotide polymorphism. These efforts are designed to uncover novel drug targets and define the subpopulation of asthmatics most likely to benefit from therapy.

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Immunology
Research Summary: 
Determine the molecular mechanisms and causal variants of asthma-associated genetic loci.
Publications: 

Corticosteroid and Long-Acting ß-Agonist Therapy Reduces Epithelial Goblet Cell Metaplasia.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Lachowicz-Scroggins ME, Finkbeiner WE, Gordon ED, Yuan S, Zlock L, Bhakta NR, Woodruff PG, Fahy JV, Boushey HA

IL1RL1 asthma risk variants regulate airway type 2 inflammation.

JCI insight

Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, Lachowicz-Scroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay MA, Sheldon RT, Peters MC, Nocka KH, Fahy JV, Seibold MA

Alternative splicing of interleukin-33 and type 2 inflammation in asthma.

Proceedings of the National Academy of Sciences of the United States of America

Gordon ED, Simpson LJ, Rios CL, Ringel L, Lachowicz-Scroggins ME, Peters MC, Wesolowska-Andersen A, Gonzalez JR, MacLeod HJ, Christian LS, Yuan S, Barry L, Woodruff PG, Ansel KM, Nocka K, Seibold MA, Fahy JV

Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25.

American journal of respiratory and critical care medicine

Gordon ED, Locksley RM, Fahy JV

Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma.

The Journal of allergy and clinical immunology

Sweerus K, Lachowicz-Scroggins M, Gordon E, LaFemina M, Huang X, Parikh M, Kanegai C, Fahy JV, Frank JA