Biomedical Sciences Graduate Program | University of California, San Francisco

Esteban Gonzalez Burchard, MD, MPH
Pharmacogenomics and Genetic Epidemiology of Pulmonary Diseases

Selected Publications | Complete Publications

phone	(415) 514-9677
email	esteban@sfgh.ucsf.edu
additional websites	Lab Website UCSF DNA Bank
secondary research affiliation

Esteban González Burchard received his M.D. degree from Stanford University School of Medicine in 1995. He completed clinical training in Internal Medicine at Harvard's Brigham and Women's Hospital and Pulmonary/Critical Care Medicine training at UCSF. Dr. González Burchard also completed clinical research training at the Harvard School of Public Health. He received his M.P.H. degree in epidemiology from UC Berkeley. He joined the UCSF faculty in 2001. Dr. González Burchard directs the UCSF DNA Bank and the Asthma Genetics Laboratory. Dr. González Burchard's major academic interest centers on identifying genetic and environmental risk factors for asthma and drug response (pharmacogenetics) in ethnically diverse populations.

Research Interests

The overall goal of my research group is to identify and characterize the major genetic components that predispose to asthma and modify drug response (pharmacogenetics). Our research focuses on identifying racially-specific genetic and biologic risk factors for asthma and asthma severity among U.S. ethnic and racial minority groups. In addition, we are interested in how race and racially-specific genetic differences modify disease and response to therapies. We work in collaboration with a multi-disciplinary team of investigators. This team includes faculty with expertise in genetic epidemiology, biostatistics, clinical asthma, and pulmonary molecular and cell biology and genomics. Using tools from these disciplines, we conduct studies designed to elucidate genetic risk factors for asthma and asthma severity. Our research is applied and through collaborations our work often crosses over to other disease phenotypes. We enjoy collaborations throughout UCSF and outside of UCSF. Within UCSF we are based in the Schools of Pharmacy and Medicine and the Institute for Human Genetics.

Selected Publications

Williams, L.K., Oliver, J., Peterson, E.L., Bobbitt, K. R., McCabe, M.J., Smolarek, D., Havstad, S.L., Wegienka, G., Burchard, E.G., Ownby, D.R., Johnson, C.C.. Gene-environment interactions between CD14 C-260T and endotoxin exposure on Foxp3+ and Foxp3- CD4+ lymphocyte numbers and total serum IgE in early childhood. Annals of Allergy, Asthma & Immunology. In press. August 2007.

Paschou, P, Ziv, E, Burchard, E.G., Choudhry, S, Rodriguez-Cintron, W, Mahoney, M.W., Drineas, P. PCA-correlated SNPs for Structure Identification in Worldwide Human Populations. Public Library of Science (PLoS) . In press. July 2007.

Tang, H, Choudhry, S, Mei, R, Morgan, M, Rodriguez-Cintron, W, González Burchard, E , Risch, NJ.
Recent Genetic Selection in the Ancestral Admixture of Puerto Ricans. Am J Hum Genet. In press. May 2007.

*Naqvi M, *Thyne S, Choudhry S, Tsai HJ, Navarro D, Castro RA, Nazario, S, Rodriguez-Santana JR, Casal J, Torres A, Chapela R,Watson HG, Meade K, LeNoir M, Avila PC, Rodriguez-Cintron W, and Burchard, EG . Ethnic-specific Differences in Bronchodilator Responsiveness Among African American, Puerto Rican, and Mexican Asthmatics. *These authors contributed equally to this manuscript. Journal of Asthma . In press. May 24, 2007.

Choudhry, S, Seibold, M.A. , Borrell, LN, Tang, H., Serebrisky, D., Chapela, R.,Rodriguez-Santana, JR, Avila, P.C., Ziv, E., Rodriguez-Cintron, W., Risch, N.J., and González Burchard, E. Dissecting Complex Diseases in Complex Populations: Asthma in Latino Americans . Proceedings of the American Thoracic Society . March 2007, in press.

Naqvi, M, Choudhry, S, Tsai, HJ, Thyne, S, Navarro, D, Nazario, S, Rodriguez-Santana, JR, Casal, J, Torres, A, Chapela, R, Watson, HG, Meade, K, Rodriguez-Cintron, W, LeNoir,M, Avila, PC, and González Burchard, E . Association between IgE levels and asthma severity among African American, Mexican, and Puerto Rican patients with asthma. J Allergy Clin Immunol . 2007 May 9.

Battle, NC, Choudhry, S, Tsai, HJ, Eng, C, Kumar, G, Beckman, K, Naqvi, M, Meade, K, Watson, HG, LeNoir, M, González Burchard, E . Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma. Am J Resp Crit Care Med, 2007 May 1;175(9):881-7.

Ziv, E, John, EM, Choudhry, S, Kho, J, Lorizio, W, Perez-Stable, EJ, González Burchard, E . Genetic ancestry and Risk Factors for Breast Cancer Among Latinas in the San Francisco Bay Area. Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1878-85.

Peralta, CA, Ziv, E, Katz, R, Reiner, A, González Burchard, E , Fried, L, Kwok, PY, Psaty, B, Shlipak, M. African ancestry, socioeconomic status and kidney function in elderly African Americans: a genetic admixture analysis. J Am Soc Nephrol. 2006 Dec;17(12):3491-6.

*Choudhry, S, * González Burchard, E , Borrell, LN, Tang, H, Gomez, I, Naqvi, M, Nazario, S, Torres, A, Casal, J, Martinez-Cruzado, JC,Ziv, E, Avila, PC, Rodriguez-Cintron, W, and Risch, NJ. Ancestry-Environment Interactions and Asthma Risk among Puerto Ricans. Am J Respir Crit Care Med . 2006 Nov 15;174(10):1088-93. *These authors contributed equally to this manuscript.

Tsai YJ, Choudhry, S, Kho, J, Beckman, K, Tsai, HJ, Navarro, D, Matallana H, Castro, RA, Lilly, CM, Nazario, S, Rodriguez-Santana, JR, Casal, J, Torres, A, Salas, J, Chapela, R,Watson, HG, Meade, K, Avila, PC, Rodriguez-Cintron, W, LeNoir, M, and González Burchard, E, on behalf of the GALA and SAGE Investigators. The PTGDR Gene is not Associated with Asthma in Three Ethnically Diverse Populations. J Allergy Clin Immunol. 2006 Dec;118(6):1242-8.

Tsai HJ, Kho JY, Shaikh N, Kho JY, Battle N, Naqvi M, Navarro D, Matallana H, Lilly CM, Eng C, Kumar G, Thyne S, Watson HG, Meade K, Le Noir M, Choudhry S, González Burchard E , from the Study of African American, Asthma, Genes and Environments (SAGE). Beta-2 Adrenergic receptor polymorphisms: Pharmacogenetic response to bronchodilator among African American asthmatics. Hum Genet. 2006 Jan; 118(5):626-39.

information last updated June 2008