Allan Basbaum, PhD

Professor & Chair
Department of Anatomy
+1 415 476-5270

Our laboratory examines the mechanisms through which tissue and nerve injury produce changes in the peripheral and central nervous system, resulting in persistent pain. In parallel studies we are examining the circuits through which pruritogens generate itch. These studies follow upon our recent work that defined mechanisms through which opioids that act at different receptor subtypes exert their pain relieving effects. The hallmark of our work is our laboratory’s multidisciplinary approach to the problem, using molecular, neuroanatomical, pharmacological and behavioral analyses in wild type and genetically modified mice. Many of these mice, including knockouts and Cre- or reporter-expressing mice are generated in our laboratory. To expand our analyses using our transgenic mouse in which wheat germ agglutinin transneuronal labeling of complex circuits can be triggered from neurons in any region of the brain or spinal cord, we now incorporate transneuronal anterograde (herpes) and retrograde (rabies) viral tracers in our circuit analyses. By combining these studies with the functional properties of the label neurons, these studies will examine the extent to which pain and itch circuits are segregated or convergent at the level of spinal cord interneurons and projection neurons. Most recently, we turned our attention to the possibility of overcoming the neurological consequences of peripheral nerve damage, by transplanting embryonic cortical GABAergic precursor cells into the spinal cord. We have demonstrated that the cells integrate into the host and can ameliorate the persistent pain and itch associated with nerve damage.

Primary Thematic Area: 
Neurobiology
Secondary Thematic Area: 
None
Research Summary: 
The Neurological Basis of Pain and Its Control

Websites

Publications: 

Neuronal aromatase expression in pain processing regions of the medullary and spinal cord dorsal horn.

The Journal of comparative neurology

Tran M, Kuhn JA, Bráz JM, Basbaum AI

Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release.

Proceedings of the National Academy of Sciences of the United States of America

Zhang C, Medzihradszky KF, Sánchez EE, Basbaum AI, Julius D

Synergistic antipruritic effects of gamma aminobutyric acid A and B agonists in a mouse model of atopic dermatitis.

The Journal of allergy and clinical immunology

Cevikbas F, Braz JM, Wang X, Solorzano C, Sulk M, Buhl T, Steinhoff M, Basbaum AI

Rebuilding CNS inhibitory circuits to control chronic neuropathic pain and itch.

Progress in brain research

Braz JM, Etlin A, Juarez-Salinas D, Llewellyn-Smith IJ, Basbaum AI

Functional Synaptic Integration of Forebrain GABAergic Precursors into the Adult Spinal Cord.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Etlin A, Bráz JM, Kuhn JA, Wang X, Hamel KA, Llewellyn-Smith IJ, Basbaum AI