Alan Frankel, PhD

Professor
Department of Biochemistry and Biophysics
+1 415 476-9994

The Frankel Lab focuses on RNA-protein recognition and the assembly of RNA-based regulatory complexes. We use biochemistry, structural methods, proteomics, and virology to investigate two essential regulatory complexes in HIV: the viral Tat protein and its interactions with the host transcription machinery, and the viral Rev protein and its interactions with host nuclear export complexes. In concert with proteomic studies of HIV-human protein complexes, our studies have led to an understanding of how the virus has evolved adaptable protein interfaces to hijack these two host machines and establish a unique regulatory circuit that drives gene expression during the HIV life cycle.

Primary Thematic Area: 
Virology & Microbial Pathogenesis
Secondary Thematic Area: 
None
Research Summary: 
RNA-Protein Complexes

Websites

Publications: 

Identification and Optimization of Thienopyridine Carboxamides as Inhibitors of HIV Regulatory Complexes.

Antimicrobial agents and chemotherapy

Nakamura RL, Burlingame MA, Yang S, Crosby DC, Talbot DJ, Chui K, Frankel AD, Renslo AR

PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription.

Scientific reports

Faust TB, Li Y, Jang GM, Johnson JR, Yang S, Weiss A, Krogan NJ, Frankel AD

Functional Segregation of Overlapping Genes in HIV.

Cell

Fernandes JD, Faust TB, Strauli NB, Smith C, Crosby DC, Nakamura RL, Hernandez RD, Frankel AD

Oligomeric viral proteins: small in size, large in presence.

Critical reviews in biochemistry and molecular biology

Jayaraman B, Smith AM, Fernandes JD, Frankel AD

A structurally plastic ribonucleoprotein complex mediates post-transcriptional gene regulation in HIV-1.

Wiley interdisciplinary reviews. RNA

Fernandes JD, Booth DS, Frankel AD