Theo Nicolaides, MD

Assistant Professor
Department of Pediatrics
Department of Neurosurgery
+1 415 476-3831

I am a physician scientist in the field of pediatric neuro-oncology. I am currently an Assistant Professor at UCSF and have independent lab space in the Brain Tumor Research Center supported through an NIH SPORE award. I also am Director of the UCSF Brain Tumor Research Center Pre-Clinical (animal research) Core that generates new patient derived xenografts and cell lines from all pediatric brain tumor patients at UCSF and uses these for rationally designed preclinical experiments. My research interests are in identifying and validating therapeutic targets in brain tumors using in vitro and in vivo techniques. My current work focuses on EGFR activation in adult gliomas, and MAP kinase pathway activation in pediatric gliomas, and opportunities created for targeted therapy. We have published data supporting the substantial frequency of BRAFV600E mutations in pediatric astrocytomas, and have demonstrated the pre-clinical efficacy of PLX4032 (a BRAFV600E kinase inhibitor) in xenograft models. This data has led to a multi-center clinical trial using this approach that I chair through the Pacific Pediatric Neuro-Oncology Consortium (PNOC). My lab also performed the biology studies for a recent phase 1 trial conducted by the Pediatric Brain Tumor Consortium testing a MEK inhibitor, selumetinib, in pediatric gliomas. 

Primary Thematic Area: 
Cancer Biology & Cell Signaling
Secondary Thematic Area: 
Neurobiology
Research Summary: 
Targeted therapy for brain tumors.
Publications: 

A phase I trial of the MEK inhibitor selumetinib (AZD6244) in pediatric patients with recurrent or refractory low-grade glioma: a Pediatric Brain Tumor Consortium (PBTC) study.

Neuro-oncology

Banerjee A, Jakacki RI, Onar-Thomas A, Wu S, Nicolaides T, Young Poussaint T, Fangusaro J, Phillips J, Perry A, Turner D, Prados M, Packer RJ, Qaddoumi I, Gururangan S, Pollack IF, Goldman S, Doyle LA, Stewart CF, Boyett JM, Kun LE, Fouladi M

Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Lassaletta A, Zapotocky M, Mistry M, Ramaswamy V, Honnorat M, Krishnatry R, Guerreiro Stucklin A, Zhukova N, Arnoldo A, Ryall S, Ling C, McKeown T, Loukides J, Cruz O, de Torres C, Ho CY, Packer RJ, Tatevossian R, Qaddoumi I, Harreld JH, Dalton JD, Mulcahy-Levy J, Foreman N, Karajannis MA, Wang S, Snuderl M, Nageswara Rao A, Giannini C, Kieran M, Ligon KL, Garre ML, Nozza P, Mascelli S, Raso A, Mueller S, Nicolaides T, Silva K, Perbet R, Vasiljevic A, Faure Conter C, Frappaz D, Leary S, Crane C, Chan A, Ng HK, Shi ZF, Mao Y, Finch E, Eisenstat D, Wilson B, Carret AS, Hauser P, Sumerauer D, Krskova L, Larouche V, Fleming A, Zelcer S, Jabado N, Rutka JT, Dirks P, Taylor MD, Chen S, Bartels U, Huang A, Ellison DW, Bouffet E, Hawkins C, Tabori U

Inhibiting 4EBP1 in glioblastoma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Fan QW, Nicolaides TP, Weiss WA

Precision knockdown of EGFR gene expression using radio frequency electromagnetic energy.

Journal of neuro-oncology

Ulasov IV, Foster H, Butters M, Yoon JG, Ozawa T, Nicolaides T, Figueroa X, Hothi P, Prados M, Butters J, Cobbs C

A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma.

Cancer cell

Fan Q, Aksoy O, Wong RA, Ilkhanizadeh S, Novotny CJ, Gustafson WC, Truong AY, Cayanan G, Simonds EF, Haas-Kogan D, Phillips JJ, Nicolaides T, Okaniwa M, Shokat KM, Weiss WA