Shomyseh Sanjabi, PhD

Assistant Investigator, Gladstone Institute of Virology and Immunology
Assistant Professor
Department of Microbiology and Immunology
+1 415 734-4814

The Sanjabi Lab aims to understand how protective innate and adaptive immune responses are elicited and maintained upon mucosal transmission of viral pathogens. More specifically, we study how viral pathogens are transmitted via genital mucosa, how various antigen-presenting cells (APCs) sense the virus, and how APC activation contributes to priming, differentiation, trafficking, and formation of protective memory CD8 T cells. We utilize model pathogens together with various mouse genetic models and a combination of cellular, molecular, flow cytometric and immunohistochemical approaches to study pathogen specific anti-viral immune responses.

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Virology & Microbial Pathogenesis
Research Summary: 
Mucosal Antiviral Immunity

Websites

Publications: 

Regulation of the Immune Response by TGF-ß: From Conception to Autoimmunity and Infection.

Cold Spring Harbor perspectives in biology

Sanjabi S, Oh SA, Li MO

Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allows enhanced viral replication.

The Journal of experimental medicine

Khan S, Woodruff EM, Trapecar M, Fontaine KA, Ezaki A, Borbet TC, Ott M, Sanjabi S

Truncated form of TGF-ßRII, but not its absence, induces memory CD8+ T cell expansion and lymphoproliferative disorder in mice.

Journal of immunology (Baltimore, Md. : 1950)

Ishigame H, Mosaheb MM, Sanjabi S, Flavell RA

Excessive Th1 responses due to the absence of TGF-ß signaling cause autoimmune diabetes and dysregulated Treg cell homeostasis.

Proceedings of the National Academy of Sciences of the United States of America

Ishigame H, Zenewicz LA, Sanjabi S, Licona-Limón P, Nakayama M, Leonard WJ, Flavell RA

The polarization of immune cells in the tumour environment by TGFbeta.

Nature reviews. Immunology

Flavell RA, Sanjabi S, Wrzesinski SH, Licona-Limón P