Shomyseh Sanjabi, PhD

Assistant Investigator, Gladstone Institute of Virology and Immunology
Assistant Professor
Department of Microbiology and Immunology
+1 415 734-4814

The Sanjabi Lab aims to understand how protective innate and adaptive immune responses are elicited and maintained upon mucosal transmission of viral pathogens. More specifically, we study how viral pathogens are transmitted via genital mucosa, how various antigen-presenting cells (APCs) sense the virus, and how APC activation contributes to priming, differentiation, trafficking, and formation of protective memory CD8 T cells. We utilize model pathogens together with various mouse genetic models and a combination of cellular, molecular, flow cytometric and immunohistochemical approaches to study pathogen specific anti-viral immune responses.

Primary Thematic Area: 
Immunology
Secondary Thematic Area: 
Virology & Microbial Pathogenesis
Research Summary: 
Mucosal Antiviral Immunity

Websites

Publications: 

Differentiating Immune Cell Targets in Gut-Associated Lymphoid Tissue for HIV Cure.

AIDS research and human retroviruses

Khan S, Telwatte S, Trapecar M, Yukl S, Sanjabi S

An Optimized and Validated Method for Isolation and Characterization of Lymphocytes from HIV+ Human Gut Biopsies.

AIDS research and human retroviruses

Trapecar M, Khan S, Roan N, Chen TH, Telwatte S, Deswal M, Pao M, Somsouk M, Deeks SG, Hunt PW, Yukl S, Sanjabi S

Development of Inflammatory Bowel Disease Is Linked to a Longitudinal Restructuring of the Gut Metagenome in Mice.

mSystems

Sharpton T, Lyalina S, Luong J, Pham J, Deal EM, Armour C, Gaulke C, Sanjabi S, Pollard KS

Regulation of the Immune Response by TGF-ß: From Conception to Autoimmunity and Infection.

Cold Spring Harbor perspectives in biology

Sanjabi S, Oh SA, Li MO

Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allows enhanced viral replication.

The Journal of experimental medicine

Khan S, Woodruff EM, Trapecar M, Fontaine KA, Ezaki A, Borbet TC, Ott M, Sanjabi S