Saul Villeda, PhD

Assistant Professor
Department of Anatomy
Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
+1 415 502-1929

The ability to reverse aging in the brain may enable us to sidestep the effects of aging that promote vulnerability to neurodegenerative diseases, providing a unique and unexplored therapeutic approach. We have recently shown that systemic manipulations such as heterochronic parabiosis or young blood administration can partially reverse age-related impairments in regenerative, synaptic and cognitive functions in the aged brain. Interestingly, heterochronic parabiosis studies revealed an age-dependent bi-directionality in the influence of the systemic environment indicating pro-youthful factors in young blood elicit rejuvenation while pro-aging factors in old blood drive pre-mature aging. Therefore, targeting pro-aging factors in old blood may provide an alternative approach to rejuvenate aging phenotypes. Our lab is interested in understanding what drives regenerative and cognitive impairments in the aging brain, and how the effects of aging can be reversed in the old brain. Ultimately, our goal is to elucidate cellular and molecular mechanisms that promote brain rejuvenation as a means by which to combat age-related neurodegeneration and cognitive dysfunction.

Primary Thematic Area: 
Neurobiology
Secondary Thematic Area: 
Developmental & Stem Cell Biology
Research Summary: 
Mechanisms of Brain Aging and Rejuvenation

Websites

Publications: 

Preclinical Assessment of Young Blood Plasma for Alzheimer Disease.

JAMA neurology

Middeldorp J, Lehallier B, Villeda SA, Miedema SS, Evans E, Czirr E, Zhang H, Luo J, Stan T, Mosher KI, Masliah E, Wyss-Coray T

Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node.

eLife

Zhang Y, Roth TL, Gray EE, Chen H, Rodda LB, Liang Y, Ventura P, Villeda S, Crocker PR, Cyster JG

Microglia communication: Parallels between aging and Alzheimer's disease.

Clinical & experimental neuroimmunology

Udeochu JC, Shea JM, Villeda SA

Translational strategies in aging and age-related disease.

Nature medicine

Armanios M, de Cabo R, Mannick J, Partridge L, van Deursen J, Villeda S

Fat Chance for Neural Stem Cells in Alzheimer's Disease.

Cell stem cell

Gontier G, Lin K, Villeda SA