Saptarsi Haldar, MD, BS

Associate Investigator, Gladstone Institutes
Associate Professor of Medicine
Cardiovascular Division
+1 415 734-4058

Clinical: I am a cardiologist specializing in general adult cardiology.

Research: I am a principal investigator at the Gladstone Institute of Cardiovascular Disease and the University of California, San Francisco. My scientific focus is to understand gene-regulatory and epigenetic mechanisms governing cell state transitions in the cardiovascular system and in skeletal muscle with an ultimate goal of finding novel therapeutic strategies to prevent and treat heart failure, cardiometabolic, and myopathic diseases.

A major focus of our team is in the pathobiology of heart failure, a devastating disease for which morbidity and mortality remain extremely high despite current standards of medical care. As a practicing physician-scientist that recognizes this major unmet need, one of my laboratory’s central goals is to discover novel mechanisms underlying heart failure pathogenesis and to develop new therapeutic strategies for this extremely common and lethal condition. We have a deep interest in the very nascent area of cardiovascular epigenetics and seek to unravel how chromatin-dependent signal transduction drives cardiovascular plasticity during physiological and pathophysiological states. As epigenetic regulators and chromatin-associated proteins are often tractable drug targets, we actively seek to translate our findings into novel transcriptionally-active cardiovascular therapeutics.

Primary Thematic Area: 
Vascular & Cardiac Biology
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Gene Regulation and Epigenetics in Cardiovascular and Metabolic Physiology/Disease

Websites

Publications: 

BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure.

Science translational medicine

Duan Q, McMahon S, Anand P, Shah H, Thomas S, Salunga HT, Huang Y, Zhang R, Sahadevan A, Lemieux ME, Brown JD, Srivastava D, Bradner JE, McKinsey TA, Haldar SM

Sarcomeres and Cardiac Growth: Tension in the Relationship.

Trends in molecular medicine

Haldar SM, Srivastava D

Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program.

Proceedings of the National Academy of Sciences of the United States of America

Morrison-Nozik A, Anand P, Zhu H, Duan Q, Sabeh M, Prosdocimo DA, Lemieux ME, Nordsborg N, Russell AP, MacRae CA, Gerber AN, Jain MK, Haldar SM

Megamitochondria in Cardiomyocytes of a Knockout (Klf15-/-) Mouse.

Ultrastructural pathology

Tandler B, Fujioka H, Hoppel CL, Haldar SM, Jain MK

Differential role of an NF-?B transcriptional response element in endothelial versus intimal cell VCAM-1 expression.

Circulation research

Milstone DS, Ilyama M, Chen M, O'Donnell P, Davis VM, Plutzky J, Brown JD, Haldar SM, Siu A, Lau AC, Zhu SN, Basheer MF, Collins T, Jongstra-Bilen J, Cybulsky MI