Noah Zaitlen, PhD

Assistant Professor
Department of Medicine
Lung Biology Center
+1 415 502-2027

We develop statistical and computational tools to discover the genetic basis of complex phenotypes. We are especially interested in human disease, variation in drug/treatment response, and disease outcomes. Current projects primarily focus on incorporating environmental context into medical genetics. These include developing novel techniques to partition the proportion of phenotype driven by genetic and environmental factors in world-wide populations (Nature versus Nurture), and improving our power to identify disease causing mutations by leveraging gene-expression, meta-genomic, and clinical data such as smoking status, BMI, and age.

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Immunology
Research Summary: 
Development of statistical methods for uncovering the genetic basis of human disease

Websites

Publications: 

Differential methylation between ethnic sub-groups reflects the effect of genetic ancestry and environmental exposures.

eLife

Galanter JM, Gignoux CR, Oh SS, Torgerson D, Pino-Yanes M, Thakur N, Eng C, Hu D, Huntsman S, Farber HJ, Avila PC, Brigino-Buenaventura E, LeNoir MA, Meade K, Serebrisky D, Rodríguez-Cintrón W, Kumar R, Rodríguez-Santana JR, Seibold MA, Borrell LN, Burchard EG, Zaitlen N

Genetic Mechanisms Leading to Sex Differences Across Common Diseases and Anthropometric Traits.

Genetics

Traglia M, Bseiso D, Gusev A, Adviento B, Park DS, Mefford JA, Zaitlen N, Weiss LA

The Effects of Migration and Assortative Mating on Admixture Linkage Disequilibrium.

Genetics

Zaitlen N, Huntsman S, Hu D, Spear M, Eng C, Oh SS, White MJ, Mak A, Davis A, Meade K, Brigino-Buenaventura E, LeNoir MA, Bibbins-Domingo K, Burchard EG, Halperin E

Pleiotropic Mechanisms Indicated for Sex Differences in Autism.

PLoS genetics

Mitra I, Tsang K, Ladd-Acosta C, Croen LA, Aldinger KA, Hendren RL, Traglia M, Lavillaureix A, Zaitlen N, Oldham MC, Levitt P, Nelson S, Amaral DG, Herz-Picciotto I, Fallin MD, Weiss LA

DNA Methylation Profiling of Uniparental Disomy Subjects Provides a Map of Parental Epigenetic Bias in the Human Genome.

American journal of human genetics

Joshi RS, Garg P, Zaitlen N, Lappalainen T, Watson CT, Azam N, Ho D, Li X, Antonarakis SE, Brunner HG, Buiting K, Cheung SW, Coffee B, Eggermann T, Francis D, Geraedts JP, Gimelli G, Jacobson SG, Le Caignec C, de Leeuw N, Liehr T, Mackay DJ, Montgomery SB, Pagnamenta AT, Papenhausen P, Robinson DO, Ruivenkamp C, Schwartz C, Steiner B, Stevenson DA, Surti U, Wassink T, Sharp AJ