Noah Zaitlen, PhD

Assistant Professor
Department of Medicine
Lung Biology Center
+1 415 502-2027

We develop statistical and computational tools to discover the genetic basis of complex phenotypes. We are especially interested in human disease, variation in drug/treatment response, and disease outcomes. Current projects primarily focus on incorporating environmental context into medical genetics. These include developing novel techniques to partition the proportion of phenotype driven by genetic and environmental factors in world-wide populations (Nature versus Nurture), and improving our power to identify disease causing mutations by leveraging gene-expression, meta-genomic, and clinical data such as smoking status, BMI, and age.

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Research Summary: 
Development of statistical methods for uncovering the genetic basis of human disease



Differential methylation between ethnic sub-groups reflects the effect of genetic ancestry and environmental exposures.


Galanter JM, Gignoux CR, Oh SS, Torgerson D, Pino-Yanes M, Thakur N, Eng C, Hu D, Huntsman S, Farber HJ, Avila PC, Brigino-Buenaventura E, LeNoir MA, Meade K, Serebrisky D, Rodríguez-Cintrón W, Kumar R, Rodríguez-Santana JR, Seibold MA, Borrell LN, Burchard EG, Zaitlen N

Mixed Model Association with Family-Biased Case-Control Ascertainment.

American journal of human genetics

Hayeck TJ, Loh PR, Pollack S, Gusev A, Patterson N, Zaitlen NA, Price AL

Genetic Mechanisms Leading to Sex Differences Across Common Diseases and Anthropometric Traits.


Traglia M, Bseiso D, Gusev A, Adviento B, Park DS, Mefford JA, Zaitlen N, Weiss LA

The Effects of Migration and Assortative Mating on Admixture Linkage Disequilibrium.


Zaitlen N, Huntsman S, Hu D, Spear M, Eng C, Oh SS, White MJ, Mak A, Davis A, Meade K, Brigino-Buenaventura E, LeNoir MA, Bibbins-Domingo K, Burchard EG, Halperin E

Pleiotropic Mechanisms Indicated for Sex Differences in Autism.

PLoS genetics

Mitra I, Tsang K, Ladd-Acosta C, Croen LA, Aldinger KA, Hendren RL, Traglia M, Lavillaureix A, Zaitlen N, Oldham MC, Levitt P, Nelson S, Amaral DG, Herz-Picciotto I, Fallin MD, Weiss LA