Matthew Springer, PhD

Professor
Department of Medicine
Cardiology Division
+1 415 502-8404

RESEARCH INTERESTS:

Dr. Matthew L. Springer received his BA from the University of California, Berkeley in 1985 and his PhD from Stanford University in 1992. He did postdoctoral research at Stanford and continued his research there as a senior scientist until joining the UCSF faculty in 2003, where he is currently one of two non-clinicians on the faculty of the Division of Cardiology. The close juxtaposition of his basic research background with the clinical cardiologists in the Division has resulted in an active translational research program.

Dr. Springer's research interests include cell therapy and gene therapy approaches to studying cardiovascular disease, with the goals of exploring potential treatments and understanding underlying mechanisms involved in angiogenesis, vascular function, and treatments for myocardial infarction. The laboratory is studying the therapeutic effects of ultrasound-guided bone marrow cell implantation into the heart after myocardial infarction, with a special emphasis on the therapeutic implications of the age and cardiac disease state of the cell donor. Similarly, the lab is studying the effects of age and disease on circulating angiogenic cells (sometimes called endothelial progenitor cells), with a focus on the roles of endothelial nitric oxide synthase and nitric oxide in the function of these cells. The main angiogenesis interest is how cardiac motion and cyclical forces influences angiogenic gene expression and cell behavior. Currently, a large effort involves the study of vascular reactivity using a rat model of endothelium-dependent flow-mediated vasodilation that they developed, and how vascular endothelial function is affected by exposure to secondhand smoke from tobacco and marijuana.

Primary Thematic Area: 
Vascular & Cardiac Biology
Secondary Thematic Area: 
None
Research Summary: 
Angiogenesis & vascular biology, myocardial repair, endothelial function, and second hand smoke

Websites

Featured Publications: 

One Minute of Marijuana Secondhand Smoke Exposure Substantially Impairs Vascular Endothelial Function.

Journal of the American Heart Association

Wang X, Derakhshandeh R, Liu J, Narayan S, Nabavizadeh P, Le S, Danforth OM, Pinnamaneni K, Rodriguez HJ, Luu E, Sievers RE, Schick SF, Glantz SA, Springer ML

Circulating angiogenic cell function is inhibited by cortisol in vitro and associated with psychological stress and cortisol in vivo.

Psychoneuroendocrinology

Aschbacher K, Derakhshandeh R, Flores AJ, Narayan S, Mendes WB, Springer ML

Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction.

Journal of the American Heart Association

Chen Q, Varga M, Wang X, Haddad DJ, An S, Medzikovic L, Derakhshandeh R, Kostyushev DS, Zhang Y, Clifford BT, Luu E, Danforth OM, Rafikov R, Gong W, Black SM, Suchkov SV, Fineman JR, Heiss C, Aschbacher K, Yeghiazarians Y, Springer ML

Impairment of Endothelial Function by Little Cigar Secondhand Smoke.

Tobacco regulatory science

Liu J, Wang X, Narayan S, Glantz SA, Schick SF, Springer ML

Brief exposure to secondhand smoke reversibly impairs endothelial vasodilatory function.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Pinnamaneni K, Sievers RE, Sharma R, Selchau AM, Gutierrez G, Nordsieck EJ, Su R, An S, Chen Q, Wang X, Derakhshandeh R, Aschbacher K, Heiss C, Glantz SA, Schick SF, Springer ML

Pleiotrophin gene therapy for peripheral ischemia: evaluation of full-length and truncated gene variants.

PloS one

Fang Q, Mok PY, Thomas AE, Haddad DJ, Saini SA, Clifford BT, Kapasi NK, Danforth OM, Usui M, Ye W, Luu E, Sharma R, Bartel MJ, Pathmanabhan JA, Ang AA, Sievers RE, Lee RJ, Springer ML

Pharmacological inhibition of S-nitrosoglutathione reductase improves endothelial vasodilatory function in rats in vivo.

Journal of applied physiology (Bethesda, Md. : 1985)

Chen Q, Sievers RE, Varga M, Kharait S, Haddad DJ, Patton AK, Delany CS, Mutka SC, Blonder JP, Dubé GP, Rosenthal GJ, Springer ML

Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response.

Science translational medicine

Wang X, Takagawa J, Lam VC, Haddad DJ, Tobler DL, Mok PY, Zhang Y, Clifford BT, Pinnamaneni K, Saini SA, Su R, Bartel MJ, Sievers RE, Carbone L, Kogan S, Yeghiazarians Y, Hermiston M, Springer ML

Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy.

Molecular therapy : the journal of the American Society of Gene Therapy

Yeghiazarians Y, Zhang Y, Prasad M, Shih H, Saini SA, Takagawa J, Sievers RE, Wong ML, Kapasi NK, Mirsky R, Koskenvuo J, Minasi P, Ye J, Viswanathan MN, Angeli FS, Boyle AJ, Springer ML, Grossman W

In vivo measurement of flow-mediated vasodilation in living rats using high-resolution ultrasound.

American journal of physiology. Heart and circulatory physiology

Heiss C, Sievers RE, Amabile N, Momma TY, Chen Q, Natarajan S, Yeghiazarians Y, Springer ML

Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography.

American journal of physiology. Heart and circulatory physiology

Springer ML, Sievers RE, Viswanathan MN, Yee MS, Foster E, Grossman W, Yeghiazarians Y

Localized arteriole formation directly adjacent to the site of VEGF-induced angiogenesis in muscle.

Molecular therapy : the journal of the American Society of Gene Therapy

Springer ML, Ozawa CR, Banfi A, Kraft PE, Ip TK, Brazelton TR, Blau HM

VEGF gene delivery to muscle: potential role for vasculogenesis in adults.

Molecular cell

Springer ML, Chen AS, Kraft PE, Bednarski M, Blau HM