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John Rubenstein, MD, PhD

John Rubenstein, MD, PhD
Professor, Department of Psychiatry
Research Summary:
Genetic Control of Development and Diseases of the Forebrain
We study the following processes in the development mouse forebrain:
  • Mechanisms governing regional and cell type specification within the cortex and basal ganglia.
  • Transcriptional hierarchies, including identification of gene regulatory elements (enhancers), which govern cell fate decisions in the cerebral cortex, basal ganglia, and hypothalamus.
  • Molecular mechanisms controling cell migration.
  • Genetic studies of human neurogenetic disorders, such as Autism and Epilepsy.

Selected Publications

Rubenstein, J.L.R., Martinez, S., Shimamura, K. and Puelles, L. (1994). The prosomeric model: a proposal for the organization of the embryonic forebrain. Science. 266, 578-560.

Anderson S.A., Eisenstat D., Shi L. and Rubenstein J.L.R. (1997). Interneuron migration from basal forebrain: dependence on Dlx genes. Science, 278, 474-476.

Miyashita-Lin, E.M., Hevner, R., Montzka Wassarman, K., Martinez, S. and Rubenstein, J.L.R. (1999). Early neocortical regionalization is preserved in the absence of thalamic innervation. Science, 285: 906-909.

Hevner, R.F., Shi, L., Justice, N., Hsueh Y-P, Sheng, M., Smiga, S., Bulfone, A., Goffinet, A.M. and Rubenstein, J.L.R. (2001). Tbr1 regulates differentiation of the preplate and layer 6. Neuron, 29: 353-366.

MarĂ­n, O., Yarom, A., Bagri, A., Tessier-Lavigne, M., Rubenstein, JLR. (2001). Semaphorin-Neuropilin interactions mediate sorting of striatal and cortical interneurons during development.  Science 293, 872-875.

Depew, M.J., Lufkin, T. and Rubenstein, J.L.R. (2002). Specification of jaw subdivisions by Dlx genes, Science, 298:381-385.

Cobos I., Calcagnotto, M.E., Vilaythong, A.J., Noebels, J., Baraban S.C., Rubenstein J.L.R. (2005). Mice Lacking the Dlx1 Transcription Factor Exhibit Subtype-Specific Loss of Interneurons, Reduced Synaptic Inhibition and Epilepsy. Nature Neuroscience. 8:1059-1068.

Cholfin J. and Rubenstein J.L.R. (2007). Patterning of frontal cortex subdivisions by Fgf17. PNAS. 104(18):7652-7657.

Wang Y., Li G., Stanco A., Long JE., Crawford D., Potter G.B., Pleasure S., Behrens T., Rubenstein J.L.R. (2011). CXCR4 and CXCR7 Have Distinct Functions in Regulating Interneuron Migration; Neuron 13;69(1):61-76.

Flandin, P., Zhou Y., Vogt V., Jeong J., Long J.E., Potter G.B., Westphal, H., Rubenstein J.L.R. (2011). Lhx6 and Lhx8 Coordinately Induce Neuronal Expression of Shh That Controls the Generation of Interneuron Progenitors. Neuron, 70(5):939-950.

McKinsey GL, Lindtner S, Trzcinski B, Visel A, Pennacchio L, Huylebroeck D, Higashi Y, and Rubenstein JLR. (2013). Dlx1&2-Dependent Expression of Zfhx1b (Sip1, Zeb2) Regulates the Fate Switch Between Cortical and Striatal Interneurons. Neuron, 77(1):83-98.

Visel A, Taher L, Girgis H, May D, Golonzhka O, Hoch R, McKinsey GL, Pattabiraman K, Silberberg SN, Blow MJ, Hansen DV, Nord AS, Akiyama JA, Holt A, Hosseini R, Phouanenavong S, Plajzer-Frick I, Shoukry M, Afzal V, Kaplan T Kriegstein AR, Rubin EM, Ovcharenko I, Pennacchio LA, Rubenstein JLR. (2013). A High-Resolution Enhancer Atlas of the Developing Telencephalon. Cell. 152(4):895-908.