Jimmie Ye, PhD

Assistant Professor
Department of Epidemiology & Biostatistics
Institute for Human Genetics
+1 415 476-6933

The Ye lab is interested in how the interaction between genetics and environment affect human variation at the level of molecular phenotypes. To study these interactions, the lab couples high-throughput sequencing approaches that measure cellular response  under environmental challenges with population genetics where such measurements are collected and analyzed across large patient cohorts. The lab develops novel experimental approaches that enable the large-scale collection of functional genomic data en masse and computational approaches that translate the data into novel biological insights. This approach is used to initially study primary human immune cells in both healthy and diseased patients to understand host pathogen interactions and its role in autoimmunity.

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Immunology
Research Summary: 
Genetics of human immune response

Websites

Publications: 

CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells.

Scientific reports

Rupp LJ, Schumann K, Roybal KT, Gate RE, Ye CJ, Lim WA, Marson A

A tissue checkpoint regulates type 2 immunity.

Nature immunology

Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM

Transethnic Genetic-Correlation Estimates from Summary Statistics.

American journal of human genetics

Brown BC

Selection and explosive growth alter genetic architecture and hamper the detection of causal rare variants.

Genome research

Uricchio LH, Zaitlen NA, Ye CJ, Witte JS, Hernandez RD

Parsing the Interferon Transcriptional Network and Its Disease Associations.

Cell

Mostafavi S, Yoshida H, Moodley D, LeBoité H, Rothamel K, Raj T, Ye CJ, Chevrier N, Zhang SY, Feng T, Lee M, Casanova JL, Clark JD, Hegen M, Telliez JB, Hacohen N, De Jager PL, Regev A, Mathis D, Benoist C