Esteban G. Burchard, MD, MPH

Professor
Department of Bioengineering and Therapeutic Sciences
+1 415 514-9677
Research Description: 

Esteban González Burchard, M.D., M.P.H. is a UCSF Distinguished, Endowed, Tenured Professor of Pharmacy and Medicine. He is a Pulmonary & Critical Care Physician-Scientist trained in Genetics, Immunology, Epidemiology, Pharmacogenetics, and phase 1 clinical trials.

I am passionate about understanding why and how the risk of disease and drug response vary by race and genetic ancestry. I established a national and international clinical network. My collaborators and I recruited > 16,000 African American, Puerto Rican, and Mexican children with/without asthma. I elected to study these populations because they have the highest and lowest asthma prevalence and mortality worldwide.

I led a diverse cross-functional national and international team of ~ 60 physicians, pharmacists, and scientists. Most of my 368 publications have come from these data. We combined advanced whole-genome and RNA sequencing data with social and environmental variables to study asthma, eczema, immunology, and drug response in racially mixed (admixed) populations. We are the largest contributor of data from non-European populations to the NIH/NHLBI and share our data worldwide. My research has been consistently funded by the NIH, FDA, and industry for 27 years, for a total of > $100 million.

Results from these data have placed us at the epicenter of the international debate on race and genetic ancestry in medicine. I have excellent oral and written communication skills and can effectively communicate complex and racially significant clinical and scientific concepts. I am committed to leveraging my belief in leadership, teamwork, and resiliency to contribute to clinical and biomedical research.

This body of work epitomizes Dr. Burchard’s ongoing drive to use science to improve the care of minority patients and mentorship of physicians, scientists, and students with the goal of improving diversity, equity, and inclusion in science and medicine.

Visit my lab page to learn more: https://pharm.ucsf.edu/burchard

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
None
Research Summary: 
Pharmacogenomics and Genetic Epidemiology of Pulmonary Diseases

Websites

Publications: 

Novel insights into the whole blood DNA methylome of asthma in ethnically diverse children and youth.

The European respiratory journal

Herrera-Luis E, de la Rosa-Baez C, Huntsman S, Eng C, Beckman KB, Lenoir MA, Rodriguez-Santana J, Villar J, Laprise C, Borrell LN, Ziv E, Burchard EG, Pino-Yanes M

European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.

Nature communications

Budu-Aggrey A, Kilanowski A, Sobczyk MK, 23andMe Research Team, Shringarpure SS, Mitchell R, Reis K, Reigo A, Estonian Biobank Research Team, Mägi R, Nelis M, Tanaka N, Brumpton BM, Thomas LF, Sole-Navais P, Flatley C, Espuela-Ortiz A, Herrera-Luis E, Lominchar JVT, Bork-Jensen J, Marenholz I, Arnau-Soler A, Jeong A, Fawcett KA, Baurecht H, Rodriguez E, Alves AC, Kumar A, Sleiman PM, Chang X, Medina-Gomez C, Hu C, Xu CJ, Qi C, El-Heis S, Titcombe P, Antoun E, Fadista J, Wang CA, Thiering E, Wu B, Kress S, Kothalawala DM, Kadalayil L, Duan J, Zhang H, Hadebe S, Hoffmann T, Jorgenson E, Choquet H, Risch N, Njølstad P, Andreassen OA, Johansson S, Almqvist C, Gong T, Ullemar V, Karlsson R, Magnusson PKE, Szwajda A, Burchard EG, Thyssen JP, Hansen T, Kårhus LL, Dantoft TM, Jeanrenaud ACSN, Ghauri A, Arnold A, Homuth G, Lau S, Nöthen MM, Hübner N, Imboden M, Visconti A, Falchi M, Bataille V, Hysi P, Ballardini N, Boomsma DI, Hottenga JJ, Müller-Nurasyid M, Ahluwalia TS, Stokholm J, Chawes B, Schoos AM, Esplugues A, Bustamante M, Raby B, Arshad S, German C, Esko T, Milani LA, Metspalu A, Terao C, Abuabara K, Løset M, Hveem K, Jacobsson B, Pino-Yanes M, Strachan DP, Grarup N, Linneberg A, Lee YA, Probst-Hensch N, Weidinger S, Jarvelin MR, Melén E, Hakonarson H, Irvine AD, Jarvis D, Nijsten T, Duijts L, Vonk JM, Koppelmann GH, Godfrey KM, Barton SJ, Feenstra B, Pennell CE, Sly PD, Holt PG, Williams LK, Bisgaard H, Bønnelykke K, Curtin J, Simpson A, Murray C, Schikowski T, Bunyavanich S, Weiss ST, Holloway JW, Min JL, Brown SJ, Standl M, Paternoster L

Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells.

Clinical epigenetics

Perez-Garcia J, Pino-Yanes M, Plender EG, Everman JL, Eng C, Jackson ND, Moore CM, Beckman KB, Medina V, Sharma S, Winnica DE, Holguin F, Rodríguez-Santana J, Villar J, Ziv E, Seibold MA, Burchard EG

WHOLE GENOME SEQUENCING ANALYSIS OF BODY MASS INDEX IDENTIFIES NOVEL AFRICAN ANCESTRY-SPECIFIC RISK ALLELE.

medRxiv : the preprint server for health sciences

Zhang X, Brody JA, Graff M, Highland HM, Chami N, Xu H, Wang Z, Ferrier K, Chittoor G, Josyula NS, Li X, Li Z, Allison MA, Becker DM, Bielak LF, Bis JC, Boorgula MP, Bowden DW, Broome JG, Buth EJ, Carlson CS, Chang KM, Chavan S, Chiu YF, Chuang LM, Conomos MP, DeMeo DL, Du M, Duggirala R, Eng C, Fohner AE, Freedman BI, Garrett ME, Guo X, Haiman C, Heavner BD, Hidalgo B, Hixson JE, Ho YL, Hobbs BD, Hu D, Hui Q, Hwu CM, Jackson RD, Jain D, Kalyani RR, Kardia SLR, Kelly TN, Lange EM, LeNoir M, Li C, Marchand LL, McDonald MN, McHugh CP, Morrison AC, Naseri T, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, O'Connell J, O'Donnell CJ, Palmer ND, Pankow JS, Perry JA, Peters U, Preuss MH, Rao DC, Regan EA, Reupena SM, Roden DM, Rodriguez-Santana J, Sitlani CM, Smith JA, Tiwari HK, Vasan RS, Wang Z, Weeks DE, Wessel J, Wiggins KL, Wilkens LR, Wilson PWF, Yanek LR, Yoneda ZT, Zhao W, Zöllner S, Arnett DK, Ashley-Koch AE, Barnes KC, Blangero J, Boerwinkle E, Burchard EG, Carson AP, Chasman DI, Chen YI, Curran JE, Fornage M, Gordeuk VR, He J, Heckbert SR, Hou L, Irvin MR, Kooperberg C, Minster RL, Mitchell BD, Nouraie M, Psaty BM, Raffield LM, Reiner AP, Rich SS, Rotter JI, Shoemaker MB, Smith NL, Taylor KD, Telen MJ, Weiss ST, Zhang Y, Costa NH, Sun YV, Lin X, Cupples LA, Lange LA, Liu CT, Loos RJF, North KE, Justice AE