Deepak Srivastava, MD

Younger Family Director, Gladstone Institute of Cardiovascular Disease
Wilma and Adeline Pirag Distinguished Professor in Pediatric Developmental Cardiology
Professor
Department of Pediatrics
Department of Biochemistry and Biophysics
+1 415 734-2716

Our laboratory focuses on understanding the causes of heart disease and on using knowledge of cardiac developmental pathways to devise novel therapeutic approaches for human cardiac disorders. Specifically, we study the molecular events regulating early and late developmental decisions that instruct progenitor cells to adopt a cardiac cell fate and subsequently fashion a functioning heart. We focus on transcriptional and post-transcriptional steps, including those involving microRNAs. We have leveraged this knowledge to reprogram fibroblasts directly into cardiomyocyte-like cells for regenerative purposes. We also seek to identify the causes of human cardiovascular disease by applying modern genetic technologies for the study of complex traits such as congenital heart disease. By using a spectrum of approaches including mouse and human genetics, molecular and developmental biology, and biochemistry we hope to develop a broad understanding of the biology underlying cardiogenesis and cardiovascular disorders.

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
Human Genetics
Research Summary: 
Molecular and Genetic Dissection of Cardiogenesis and its role in human disease

Websites

Publications: 

Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis.

Cell

Ang YS, Rivas RN, Ribeiro AJ, Srivas R, Rivera J, Stone NR, Pratt K, Mohamed TM, Fu JD, Spencer CI, Tippens ND, Li M, Narasimha A, Radzinsky E, Moon-Grady AJ, Yu H, Pruitt BL, Snyder MP, Srivastava D

Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming.

Circulation

Mohamed TM, Stone NR, Berry EC, Radzinsky E, Huang Y, Pratt K, Ang YS, Yu P, Wang H, Tang S, Magnitsky S, Ding S, Ivey KN, Srivastava D

Effect of biophysical cues on reprogramming to cardiomyocytes.

Biomaterials

Sia J, Yu P, Srivastava D, Li S