David Sretavan, MD, PhD

Professor
Department of Physiology
Department of Opthalmology
sretavand@vision.ucsf.edu
The Sretavan Laboratory is actively engaged in research on nerve and axon responses to injury, disease, and on novel methods for nerve repair. Our interest in these areas builds on previous work from the laboratory on developmental molecules that control axon growth and behavior during formation of the nervous system. Collectively known as axon guidance molecules,these proteins bind receptors on cells to activate signaling pathways to fundamentally regulate cytoskeletal assembly/disassembly and calcium handling. Our research group is particularly interested in the functional roles axon guidance molecules may have in the adult nervous system, specifically in the settings of CNS injury and disease. .

A new research area for the laboratory is the use of micro and nanosystems as enabling technology for axonal repair. Methodologies for silicon-based fabrication can be combined with sensing and actuation principles to form biomedical devices that operate at the micron length scale of single cells. This field of Micro ElectroMechanical Systems (MEMS) engineering, coupled with advances in nanoscience may open up new frontiers in biological research, medical diagnostic & therapeutics. The Sretavan laboratory is leading a multidisciplinary group of researchers in MEMS engineering, nanoscience, biophysics, neurobiology and neurosurgery, to develop a microsystem platform for the microsurgical reconstruction and repair of single axons.

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
Neurobiology
Research Summary: 
Mechanisms of axon injury, disease, and novel methods of axon repair

Websites

Publications: 

Biocompatible Multifunctional Black-Silicon for Implantable Intraocular Sensor.

Advanced healthcare materials

Lee JO, Narasimhan V, Du J, Ndjamen B, Sretavan D, Choo H

Regulation of axon regeneration by the RNA repair and splicing pathway.

Nature neuroscience

Song Y, Sretavan D, Salegio EA, Berg J, Huang X, Cheng T, Xiong X, Meltzer S, Han C, Nguyen TT, Bresnahan JC, Beattie MS, Jan LY, Jan YN

Ectopic vesicular glutamate release at the optic nerve head and axon loss in mouse experimental glaucoma.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Fu CT, Sretavan DW

Rabbit models for continuous curvilinear capsulorhexis instruction.

Journal of cataract and refractive surgery

Ruggiero J, Keller C, Porco T, Naseri A, Sretavan DW

Involvement of EphB/Ephrin-B signaling in axonal survival in mouse experimental glaucoma.

Investigative ophthalmology & visual science

Fu CT, Sretavan D