Atul Butte, MD, PhD

Professor
Department of Pediatrics
+1 415 514-0528

Atul Butte, MD, PhD is the inaugural Director of the Institute of Computational Health Sciences (ichs.ucsf.edu) at the University of California, San Francisco, and a Distinguished Professor of Pediatrics. Dr. Butte is also the Executive Director for Clinical Informatics across the six University of California Medical Schools and Medical Centers. Dr. Butte trained in Computer Science at Brown University, worked as a software engineer at Apple and Microsoft, received his MD at Brown University, trained in Pediatrics and Pediatric Endocrinology at Children's Hospital Boston, then received his PhD from Harvard Medical School and MIT. Dr. Butte has authored over 200 publications, with research repeatedly featured in Wired Magazine, the New York Times, and the Wall Street Journal. Dr. Butte was elected into the National Academy of Medicine in 2015, and in 2013, he was recognized by the White House as an Open Science Champion of Change for promoting science through publicly available data. Dr. Butte is also a founder of three investor-backed data-driven companies: Personalis, providing medical genome sequencing services, Carmenta (acquired by Progenity), discovering diagnostics for pregnancy complications, and NuMedii, finding new uses for drugs through open molecular data. Dr. Butte is a principal investigator of three major programs: the California Initiative to Advance Precision Medicine; ImmPort, the clinical and molecular data repository for the National Institute of Allergy and Infectious Diseases; and the California Precision Medicine Consortium, helping recruit tens of thousands of participants into President Obama's Precision Medicine Initiative.

Primary Thematic Area: 
Human Genetics
Secondary Thematic Area: 
Immunology
Research Summary: 
Dr. Butte builds and applies tools that convert more than 400 trillion points of molecular, clinical, and epidemiological data into diagnostics, therapeutics, and new insights into disease.
Publications: 

RImmPort: an R/Bioconductor package that enables ready-for-analysis immunology research data.

Bioinformatics (Oxford, England)

Shankar RD, Bhattacharya S, Jujjavarapu C, Andorf S, Wiser JA, Butte AJ

Solving Immunology?

Trends in immunology

Vodovotz Y, Xia A, Read EL, Bassaganya-Riera J, Hafler DA, Sontag E, Wang J, Tsang JS, Day JD, Kleinstein SH, Butte AJ, Altman MC, Hammond R, Sealfon SC

In silico and in vitro drug screening identifies new therapeutic approaches for Ewing sarcoma.

Oncotarget

Pessetto ZY, Chen B, Alturkmani H, Hyter S, Flynn CA, Baltezor M, Ma Y, Rosenthal HG, Neville KA, Weir SJ, Butte AJ, Godwin AK

Integrating Clinical Phenotype and Gene Expression Data to Prioritize Novel Drug Uses.

CPT: pharmacometrics & systems pharmacology

Paik H, Chen B, Sirota M, Hadley D, Butte AJ

It takes a genome to understand a village: Population scale precision medicine.

Proceedings of the National Academy of Sciences of the United States of America

Butte AJ