Aras Mattis, MD, PhD

Assistant Professor
Department of Pathology
+1 415 514-3062

The Mattis Lab is focused on identifying molecular mechanisms in normal human liver function as well as understanding complex diseases such as non-alcoholic fatty liver disease (NAFLD). In order to develop better models of this disease process we are using human induced pluripotent stem cells that are then differentiated to human hepatocyte like cells (iPSC-derived hepatocytes). Using a combination of these human derived in vitro hepatocyte models and mouse model systems we strive to develop an improved understanding of this disease.

In addition we have small projects to characterize cystic fibrosis liver disease, hepatocellular carcinoma, and cholangiocarcinoma. Located in the UCSF Department of Pathology, we make use of both collaborative efforts and IRB approved access to archived and fresh human tissue.

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
Tissue / Organ Biology & Endocrinology
Research Summary: 
Regulation of hepatic development, metabolism, and paths towards cancer.

Websites

Publications: 

A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models.

Journal of medicinal chemistry

Spangler B, Fontaine SD, Shi Y, Sambucetti L, Mattis AN, Hann B, Wells JA, Renslo AR

Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5.

Journal of immunology (Baltimore, Md. : 1950)

Frascoli M, Jeanty C, Fleck S, Moradi PW, Keating S, Mattis AN, Tang Q, MacKenzie TC

Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification.

Development (Cambridge, England)

Zdravkovic T, Nazor KL, Larocque N, Gormley M, Donne M, Hunkapillar N, Giritharan G, Bernstein HS, Wei G, Hebrok M, Zeng X, Genbacev O, Mattis A, McMaster MT, Krtolica A, Valbuena D, Simón C, Laurent LC, Loring JF, Fisher SJ

A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver.

Hepatology (Baltimore, Md.)

Mattis AN, Song G, Hitchner K, Kim RY, Lee AY, Sharma AD, Malato Y, McManus MT, Esau CC, Koller E, Koliwad S, Lim LP, Maher JJ, Raffai RL, Willenbring H

Mouse liver repopulation with hepatocytes generated from human fibroblasts.

Nature

Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S