Ann Zovein, MD

Investigator, Cardiovascular Research Institute
Assistant Professor
Department of Pediatrics
Division of Neonatology
+1 415 476-8547

Our laboratory research lies at the intersection of the vascular and hematopoietic systems. We aim to understand cell fate and identity changes during embryonic development by investigating the endothelial to hematopoietic fate transition in hemogenic endothelium. We also study vascular regulation in the context of various clinical pathologies that may have developmental origins.

Primary Thematic Area: 
Developmental & Stem Cell Biology
Secondary Thematic Area: 
Vascular & Cardiac Biology
Research Summary: 
Development and intersection of the vascular and hematopoietic systems.

Websites

Featured Publications: 

Single-cell resolution of morphological changes in hemogenic endothelium.

Development (Cambridge, England)

Bos FL, Hawkins JS, Zovein AC

Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition.

Nature communications

Lizama CO, Hawkins JS, Schmitt CE, Bos FL, Zape JP, Cautivo KM, Borges Pinto H, Rhyner AM, Yu H, Donohoe ME, Wythe JD, Zovein AC

Emergence of hematopoietic stem and progenitor cells involves a Chd1-dependent increase in total nascent transcription.

Proceedings of the National Academy of Sciences of the United States of America

Koh FM, Lizama CO, Wong P, Hawkins JS, Zovein AC, Ramalho-Santos M

Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism.

Developmental cell

Zovein AC, Luque A, Turlo KA, Hofmann JJ, Yee KM, Becker MS, Fassler R, Mellman I, Lane TF, Iruela-Arispe ML

Fate tracing reveals the endothelial origin of hematopoietic stem cells.

Cell stem cell

Zovein AC, Hofmann JJ, Lynch M, French WJ, Turlo KA, Yang Y, Becker MS, Zanetta L, Dejana E, Gasson JC, Tallquist MD, Iruela-Arispe ML

Hematopoietic development at high altitude: blood stem cells put to the test.

Development (Cambridge, England)

Zovein AC, Forsberg EC

From transplantation to transgenics: mouse models of developmental hematopoiesis.

Experimental hematology

Schmitt CE, Lizama CO, Zovein AC